A hypoechoic, tumor-like lesion in the pancreatic head and neck on endoscopic ultrasonography may be due to a high-grade pancreatic intraepithelial neoplasia/carcinoma in situ


A hypoechoic, tumor-like lesion in the pancreatic head and neck on endoscopic ultrasonography may be due to a high-grade pancreatic intraepithelial neoplasia/carcinoma in situ


Shun Sakai1, Masataka Kikuyama2, Jun Nakahodo2, Kazuro Chiba2, Hiroki Tabata2, Koji Watanabe2, Terumi Kamisawa2, Katsumasa Kobayashi1, Goro Honda3, Yusuke Ome3, Shinichiro Horiguchi4

1Department of Gastroenterology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan; 2Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan; 3Department of Surgery, Institutive of Gastroenterology, Tokyo Woman’s Medical University, Tokyo, Japan; 4Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan


High-grade pancreatic intraepithelial neoplasia (HG PanIN)/carcinoma in situ (CIS) in the pancreatic body and tail can induce parenchymal atrophy through chronic inflammatory changes presenting as a Hypoechoic area on EUS (Hypocho) or focal pancreatic parenchymal atrophy (FPPA) on computed tomography (CT) and magnetic resonance imaging (MRI). We herein discussed two patients with a hypoechoic area in the pancreatic head and neck on EUS resembling pancreatic ductal adenocarcinoma (PDAC). The lesions consisted of dense fibrosis and fat infiltration with pancreatic parenchymal atrophy around the HG PanIN/CIS in the main pancreatic duct (MPD), which penetrated the lesion and showed mild stenosis and upstream dilation. CT and MRI were unable to visualize the lesions. A specimen was obtained from one lesion by fine-needle aspiration under EUS (EUS-FNA) guidance for histopathological and cytological analysis, but the tests returned negative for adenocarcinoma. However, serial pancreatic-juice aspiration cytologic examination (SPACE) revealed adenocarcinoma in both lesions, prompting surgical resection. Histopathological examination revealed non-invasive HG PanIN/CIS in the MPD surrounded by dense fibrosis and fat deposition in the area of parenchymal atrophy. The CIS was restricted to the area of parenchymal atrophy.These two cases are noteworthy in illustrating a hypoechoic area appearing on EUS as a tumor-like lesion resembling PDAC. EUS-FNA has recently been used histopathologically to diagnose a pancreatic lesion. However, in the present and similar cases, EUS-FNA can only reveal secondary changes due to CIS unless the pancreatic duct covered by the CIS is accidentally punctured. We should bear in mind that CIS can appear as a hypoechoic area resembling PDAC on EUS, and that SPACE is the best method for diagnosing CIS in such cases.


Keywords: Carcinoma in situ; endoscopic ultrasonography; focal pancreatic parenchymal atrophy; hypoechoic stricture; serial pancreatic juice aspiration cytological examination

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How to cite this article:
Shun Sakai, Masataka Kikuyama, Jun Nakahodo, Kazuro Chiba, Hiroki Tabata, Koji Watanabe, Terumi Kamisawa, Katsumasa Kobayashi, Goro Honda,Yusuke Ome, Shinichiro Horiguchi.A hypoechoic, tumor-like lesion in the pancreatic head and neck on endoscopic ultrasonography may be due to a high-grade pancreatic intraepithelial neoplasia/carcinoma in situ.Open Journal of Gastroenterology and Hepatology, 2021, 4:50. DOI: 10.28933/ojgh-2021-05-1305


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