Open Journal of Gastroenterology and Hepatology


Obesity Induced by High Fat Diet Impairs Glucose Tolerance and Insulin Sensitivity in Rats

Research Article of Open Journal of Gastroenterology and Hepatology Obesity Induced by High Fat Diet Impairs Glucose Tolerance and Insulin Sensitivity in Rats Silva, L.M.P1; César, L.C.C1; Silva, J.J.T2; Duarte, G.I.B.P3; Rabelo, L.A4; Souza, V.N5 1Undergraduate Students-Biomedicine- CB – UFPE; 2PhD Student of Postgraduate Program in Biochemistry and Physiology - CB-UFPE. 3Professor/Researcher - dDpartment of Physiology and Pharmacology – CB – UFPE. 4Professor/Researcher- Institute of Biological Sciences and Health – ICBS – UFAL. 5Professor/Researcher - Department of Physiology and Pharmacology– CB-UFPE Introduction: Obesity is a chronic disease, besides a risk factor for cardiovascular diseases, nowadays, it is characterized as a worldwide epidemic. The food imbalance and physical inactivity are factors that contribute to the emergence of obesity as well as diabetes. Objective: To evaluate the injury on glucose tolerance and insulin sensitivity in obese rats induced by high fat diet. Methodology: Male Rats Wistar (8 weeks old) were submitted to the standard diet (chow group, 11.8% kcal-Lipids; n = 5) and dietary intervention with high fat diet during 8 weeks (HFD group, 58.4% kcal-Lipids; n= 5). It was evaluated the body weight weekly, and fasting and fed blood glucose. At the end of the experimental period, was measured the glucose tolerance, insulin sensitivity and gluconeogenesis. After the animal sacrifice, it was analyzed relative weight of white adipose tissue, as well as the adipocytes diameter (epididymal white adipose tissue) and circulating levels of leptin. Results and Discussion: The group HFD presented higher body weight (from the 2nd week of diet), an increase accumulation of epididymal and perirenal white adipose tissue. In addition, in these animals, it was observed a significant increase in the adipocytes diameter and the levels of leptin in plasma when compared to animals chow, indicating obesity with increased release of cytokines. In HFD group, the fasting blood glucose levels ...

Consumption of High Fat Diet Induces Obesity Associated to Hepatic Steatosis in Rats

Research Article of Open Journal of Gastroenterology and Hepatology Consumption of High Fat Diet Induces Obesity Associated to Hepatic Steatosis in Rats Silva, L.M.P1; Pereira, J.B1; s Neves, V.P.F.F2; Duarte, G.I.B.P3; Rabelo, L.A4; Souza, V.N5 1Undergraduate Student-Biomedicine- CB – UFPE; 2Undergraduate Student-Enfermagem- UFAL. 3Professor/Researcher - Department of Physiology and Pharmacology – CB – UFPE. 4Professor/Researcher- Institute of Biological Sciences and Health – ICBS – UFAL. 5Professor/Researcher - Department of Physiology and Pharmacology – CB – UFPE. Introduction: The high intake of carbohydrates and lipids is one of factors that contribute to the onset of Metabolic Syndrome (MetS), a complex clinical situation which brings together, besides obesity, several cardiovascular and metabolic risk factors, including non-alcoholic fatty liver disease (NAFLD). Objective: To develop a hyperlipidemic dietetic animal model to obesity associated with NAFLD. Methodology: Male Rats Wistar (8 weeks old) were submitted to the standard diet (chow group, 11,8% kcal- lipids) and hypercaloric and hyperlipidemic during 8 weeks (HFD group, 58,4% kcal-lipids). After the dietary intervention, body weight, plasma and hepatic lipid profile (triglycerides, total cholesterol, VLDL and fatty acids) and adiposity index were evaluated. Moreover, histological assessment of hepatic lipid deposition and fibrosis, as well as the hepatic damage marker (alanine aminotransferase-ALT) were evaluated. Results and Discussion: Comparing to the chow group, HFD animals presented higher body weight, both in fasting and in the fed state, increased abdominal circumference, adiposity index, as well as plasma levels of total cholesterol and non-esterified fatty acids, characterizing the dietary phenotype of obesity. In addition, the HFD group had a significant decrease in brown adipose tissue, together with the lowest weight loss induced by 16h overnight fasting, suggesting a decrease in energy expenditure. In the liver, the HFD group presented a significant increase in the levels of triglycerides, cholesterol, VLDL and non-esterified fatty acids, and, qualitatively, ...

Analysis of Hepatotoxic and Lipidic Profiles in Students of an Institution of Private Higher Education, Since the Use of Literacy Drugs

Research Article of Open Journal of Gastroenterology and Hepatology Analysis of Hepatotoxic and Lipidic Profiles in Students of an Institution of Private Higher Education, Since the Use of Literacy Drugs Santos, E.B.L¹; Lima, E.M¹; Venâncio, J.R.S¹; Barros, J.S¹; Miranda, C.E². 1Graduandos do Curso de Bacharelado em Farmácia, 2Professor Doutor do Centro Universitário Tabosa de Almeida A Introduction: In most countries, drug use is regulated by official bodies that determine which substances can be consumed. However, in many countries, alcoholic beverages and cigarettes, for example, are licit drugs although their consumption is usually of no medicinal purpose. According to the World Health Organization, alcohol dependence affects about 10 to 12% of the world’s population and alcohol is recognized as a major cause of mortality and disability. One in 20 deaths is attributed to the consumption of alcohol, a licit drug that kills more than AIDS, tuberculosis and violence together, warns the WHO. Objective: The objective of this project is to analyze hepatotoxic and lipid profiles in students of a private higher education institution, due to the use of licit drugs. Metodology: The study was a cross-sectional, experimental, quantitative and qualitative study, in which the hepatic and lipid biochemical aspects of licit drug users and the sample profile were evaluated based on a questionnaire, the total sample of the study added 300 individuals representing the population total. Results and Discussion: Based on the results it was verified that 205 (68.3%) of the students answered that they consumed at least one or more drugs in the month, being only alcohol, and only 95 (31.7%) did not use any drugs damn it. Among women, 218 (72.7%), drink and only, 28 (11.3%) do not drink. Regarding men, 27 (50%) drink and 27 (50%) do not drink. The level of consumption was observed that, 139 (46.3) consume ...

Dr. Mohammed Naeem
Chair, Patient Safety Reporting/Consultant Pediatric Intensivist/ Head PICU (A)/ Assistant Professor, Dept. of Pediatrics. Ministry National Guard Health Affairs Riyadh, Saudi Arabia

Dr Toru Ishikawa
Gastroenterology, Saiseikai Niigata Daini Hospital

Dr. George Paraskevas
Associate Professor of Anatomy Orthopedic Surgeon, Department of AnatomyMedical School, Aristotle University of Thessaloniki, Post Box: 300, Post Code: 54124, Thessaloniki, Greece

Dr. Mahaboob Vali Shaik
Assistant Professor/Senior Scientist, Department of Genetics & stem cell Research, Narayana Medical College & Hospitals

Dr. Ifeadike Chigozie Ozoemena
Associate Professor, Department of Community Medicine, Faculty of Medicine, Nnamdi Azikiwe University

Dr. Eduardo de Moura GH
Professor, niversity of São Paulo School of Medicine, São Paulo, Brazil

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1.Gomes, K.K.L; Lima, A.A.F. Living Style of Diabetic Patients Type.Open Journal of Gastroenterology and Hepatology, 2018, 1:5. DOI:10.28933/ojgh-2018-05-1005

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