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A Case of Recurrent Facial Palsy Associated with Anti-GM2: is it anyway Guillain-barré syndrome?

Case Report of International Journal of Case Reports A Case of Recurrent Facial Palsy Associated with Anti-GM2: is it anyway Guillain-barré syndrome? Giovanni Bonaccorso Region skåne Objective: A rare case of possible hereditary predisposition to autoimmune neuropathy Background: This case report is of a patient who presented two episodes of Facial paresis in her live without ascertained apparent causes. Bell’s palsy is commonly known as peripheral idiopathic facial nerve palsy, because in the most cases the triggers remain unknown (1). Case Report: I want to present a case of a 34 year old woman who we will call A.B. and who came to us to evaluate the severity of the sequelae of a Bell´s palsy and any eventual need for cosmetic measure. But she had another Bell´s Palsy 9 years ago, so I started to investigate the most common and treatable causes of Facial paresis. I found a significate increase of anti-bodies against ganglioside GM2. When I explained to her that these anti-bodies is commonly related with several neurological diseases, she started to investigate her family history and she found that his father’s brother died of Guillain Barré syndrome about 40 years ago. Keywords: Bell´s palsy, facial, palsy, paresis, Guillain Barré syndrome, ganglioside, Antibodies, GM2 ...

EFFECTIVENESS OF HORMONE BASED THERAPIES (SPIRONOLACTONE AND COMBINED ORAL CONTRACEPTIVES IN THE MANAGEMENT OF ACNE VULGARIS IN WOMEN: A SYSTEMATIC REVIEW AND META-ANALYSIS

Research Article of American Journal of Dermatological Research and Reviews Effectiveness of Hormone Based Therapies (Spironolactone and Combined Oral Contraceptives in the Management of Acne Vulgaris in Women: A Systematic review and meta-analysis Yulita Herdiana*, Asih Budiastuti, Puguh Riyanto, Diah Adriani Malik, Retno Indar Widayati, Muslimin, Hardian Department of Dermatovenereology, Faculty of Medicine, Diponegoro University/Dr. Kariadi Hospital, Dr. Sutomo Street No. 16, Semarang, Indonesia. Department of Physiology, Faculty of Medicine, Diponegoro University Background: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous follicular unit that often occurs. Acne is a skin disorder that is not life-threatening but is mostly complained of because it is aesthetically disruptive, which can cause significant psychological problems for sufferers. The management of acne vulgaris in female patients has its challenges. There are many histories of failed therapy using conventional therapy, such as with antibiotics or isotretinoin, and female patients have a predisposition to the condition of androgen excess. Also, the increasing awareness about limiting the use of antibiotics to prevent resistance in dermatological cases, including acne vulgaris, encourages other treatment options in the female patient population, one of which is hormone-based therapy. A systematic review and meta-analysis were performed of randomized clinical trials assessing the effects of Hormone Based Therapies (Spironolactone and Combined Oral Contraceptives) in the management of Acne Vulgaris in Women. Methods: Medline Pubmed, Scopus, Cochrane Library, the reference list, conference proceedings, researchers in the field of eligible studies were searched. Ten studies (n=1906 sub-jects) were included in qualitative analysis, of which eight studies (n=1842 subjects) were included in the meta-analysis. The age of the participant was greater than 14 years old. Intervention using combined oral contraceptives (n=8) or oral spironolactone (n=2). Duration of intervention (minimum six months for COC and three months for SL) and outcomes of mean difference number ...

THE EFFECTIVENESS OF PULSED DYE LASER IN MANAGEMENT OF ACNE VULGARIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Research Article of American Journal of Dermatological Research and Reviews The Effectiveness of Pulsed Dye Laser in Management of Acne Vulgaris: A Systematic review and meta-analysis Maya Rahmanita*, Retno Indar Widayati, Puguh Riyanto, Asih Budiastuti, Diah Adriani Malik, Muslimin Departement of Dermatovenereology, Faculty of Medicine, Diponegoro University / Dr. Kariadi Hospital, Dr. Sutomo street No. 16 Semarang-Indonesia. Background: Acne vulgaris is one of the most prevalent skin diseases, affecting up to 85% of teenagers and young adults. Multiple treatment options including topical, systemic or physical therapies. However, the effects of conventional therapies are limited due to antibi-otic resistance and adverse effects such as irritation and teratogenicity of isotretinoin. Light-based therapy is an alternative and/or adjuvant therapy in patients who cannot tolerate or unresponsive to conventional therapies that may provide fewer side effects, patient com-fort, fast onset of action, and with equal or greater effectiveness. We aimed to assess the effectiveness of using Pulsed Dye Laser as a treatment option for acne vulgaris. A systemat-ic Review and Meta-analysis was peformed of randomized clinical trials assessing the ef-fectiveness of Pulsed Dye Laser in management of acne vulgaris. Methods: Medline Pubmed, Scopus, Cochrane library, the reference list, conference pro-ceedings, researchers in field of eligible studies were searched. Eight studies (n=275 sub-jects) were included in qualitative analysis of which six studies (n=190 subjects) were in-cluded in meta-analysis. The mean age of the participant was 21,94 years old. Intervention using application of  Pulsed dye laser as monotherapy or combination in acne vulgaris pa-tients with follow-up at least 12 weeks. and the outcomes is a decrease mean of acne vul-garis lesions counts after received pulsed dye laser therapy. Results: Pooling of data using random effects model showed that the group that received PDL therapy alone or in combination had a lower number of acne lesions than ...

INTRA-OPERATIVE RUPTURE OF GIANT ASCENDING AORTA AND AORTIC ARCH ANEURYSM IN OPEN HEART SURGERY: A SUCCESSFUL PERI-OPERATIVE MANAGEMENT

Research Article of American Journal of Surgical Research and Reviews Intra-Operative Rupture of Giant Ascending Aorta and Aortic Arch Aneurysm In Open Heart Surgery: A Successful Peri-operative Management Issaka Zallé M.D, Mohamed El-Alaoui M.D, Djeinaba Kane M.D, Drissi Boumzebra PhD Cardiovascular Surgery Department, Mohammed VI University Hospital, Marrakech, Morocco. Introduction: Giant thoracic aortic aneurysms are rare. Most of the reported cases are not a known complication of aortic coarctation repair. Otherwise intra-operative aneurysm ruptures are rare cases but a potentially fatal complication in open heart surgery. Case report: In this article, we report the case of a 23-year-old patient with a giant ascending and arch aneurysm associated with a Standford type A chronic aortic dissection.  In the patient’s history a coarctation repair at age of five years old was noted. During an open heart surgery for ascending aorta and hemi-arch replacement under cardiopulmonary bypass, aneurysm rupture occurred before aortic cross-clamp. A successful intraoperative and post-operative management was performed. The course was uneventful. The patient was extubated without neurological damage. Moreover, there were no kidney function deterioration, no digestive and limbs ischemia. Conclusion: Intra-operative aneurysm rupture is rare but is a major operative complication whose successful repair depends on an integrated intra-operative management. Cerebrovascular and heart protection are the main determinants of patient survival. Also, the surgical team’s prompt response is the key to the successful execution of the procedure. Keywords: Ascending aorta- aneurysm - Intra-operative rupture -Cerebral Protection - Open heart surgery- Successfully management ...

Intramyocardial haemorrhage: a rare sequela of acute myopericarditis

Case Report of International Journal of Case Reports Intramyocardial haemorrhage: a rare sequela of acute myopericarditis Sahar Mohmed1, Kate Batouskaya1, Jakub Lagan2, Pei Gee Chew1,2, Dania Mohty3,4, Aleem Khand1,2,5* ¹Sahar Mohmed, MBBS, MRCP UK, (Cardiology clinical fellow, Department of Cardiology, Liverpool University Hospitals NHS Trust, Lower Lane, Liverpool L97AL, UK). ¹Kate Batouskaya (Core Medical trainee, Department of Cardiology, Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool L14 3PE). ²Jakub Lagan (Cardiologist, Department of Cardiology, Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool L14 3PE, UK). 1,2Pei Gee Chew, MBChB, MRCP UK, AFHEA, MD(Res) (Department of Cardiology, Liverpool University Hospitals NHS Trust, Lower Lane, Liverpool L97AL, Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool L14 3PE, UK). 3,4Dania Mohty, University of Limoges, Limoges, France, King Faisal Specialist Hospital, Riyadh, Saudi Arabia). 1,2,5Aleem Khand, MBChB MRCP MD Dip Interventional  Card iologyand Cardiac MRI FESC, Cardiology Consultant, Department of Cardiology, Liverpool University Hospitals NHS Trust, Lower Lane, Liverpool L97AL, Department of Cardiology, Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool L14 3PE, UK. University of Liverpool). INTRODUCTION Acute myopericarditis is an inflammatory disease of myocardium and pericardium. The disease has variable presentation ranging from mildly symptomatic cases to severe disease manifested by cardiomyopathy with associated risk of sudden cardiac death. However, the association with intramyocardial hemorrhage (IMH) has not been previously described. CASE REPORT We describe an IMH detected by cardiac magnetic resonance imaging, in a patient with classical ‘de novo’ myopericarditis. To the best of the authors’ knowledge, this has not been previously described in patients without associated haematological or connective tissue disorders. CONCLUSION The adverse prognostic signal of IMH in acute myocardial infarction may also be reflected by IMH in acute myopericarditis and lead to adverse ventricular remodeling. The pathophysiology of IMH in myopericarditis is unknown and warrants further exploration. Keywords: Intramyocardial ...

Efficacy of Doll thErapy compared with standard treatment in the control of behavioral and psychologic Symptoms and CaRegIver Burden in dEmentia: DESCRIBE a randomized, controlled study

Research Article of International Journal of Aging Research Efficacy of Doll thErapy compared with standard treatment in the control of behavioral and psychologic Symptoms and CaRegIver Burden in dEmentia: DESCRIBE a randomized, controlled study Massimiliano Massaia1, Maria Garro1, Valeria Quaranta1, Elisa Calvi1, Francesca Santagata1, Patrizia D’Amelio1,2* 1Department of Medical Science, Geriatric and Bone Diseases Unit, University of Torino, Torino, Italy. 2Department of Internal Medicine, Service of Geriatric Medicine and Geriatric Rehabilitation, University of Lausanne Hospital Centre, Lausanne, Switzerland. Behavioral and psychologic symptoms of dementia (BPSD) are frequent and represent a burden for patients and caregivers; in particular, the presence of agitation and aggression (A/A) has an important impact on patients’ quality of life. As psychotropic drugs can induce severe collateral effects, the use of a first line non-pharmacologic approach is highly recommended. Here we evaluate the effect of doll therapy (DT) on A/A in geriatric patients with moderate to severe dementia hospitalized in an acute geriatric unit. We enrolled fifty-two acute in-patients with dementia and A/A. Subjects were randomized to DT (26) or standard treatment (ST, 26), we measured agitation and caregiver burden with standard clinical scales at baseline and during treatment. In order to evaluate the effect of DT withdrawal, we carried out a telephonic follow-up interview after 1 and 4 weeks from hospital discharge. DT is more effective than ST in the control of agitation, but not in reducing the professional caregiver burden. The use of pro re nata psychotropic drugs was reduced in patients treated with DT. After DT withdrawal, A/A progressively increased. In conclusion we show that DT may be more effective than ST in the control of A/A in acute geriatric in-patients affected by dementia. Our results suggest that, in patients affected by severe to moderate forms of dementia with A/A, DT may be used ...