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Dasatinib-Induced Colitis in a Patient with Chronic Myeloid Leukemia (Chronic Phase)

Case Report of International Journal of Case Reports Dasatinib-Induced Colitis in a Patient with Chronic Myeloid Leukemia (Chronic Phase) Lubna M. Riaz1#, Khaled M. Galal2, Radwa M. Hussein2, Abdulqadir J. Nashwan1, Mohamed A. Yassin1# 1. Hematology Section/Medical Oncology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar. 2. Department of Pharmacy, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar. Chronic myeloid leukemia (CML) is a Philadelphia (Ph) chromosome-positive myeloproliferative neoplasm. The molecular consequence of reciprocal translocation t(9;22)(q34;q11) is the generation of the BCR–ABL fusion gene, which encodes a constitutively active tyrosine kinase signaling protein. The tyrosine kinase is responsible for the leukemia phenotype through the constitutive activation of multiple signaling pathways involved in the cell cycle and in adhesion and apoptosis. Dasatinib is an oral BCR-ABL tyrosine kinase inhibitor (TKI) which is mainly used for treating CML patients with resistance or intolerance to Imatinib. Dasatinib has several significant adverse reactions and gastrointestinal side effects including colitis. We report a case of a 33-year-old male, diagnosed with CML (Chronic Phase) who received Dasatinib as second-line therapy and developed chronic diarrhea and colitis attributed to Dasatinib and improved after stopping it. Keywords: Dasatinib, Chronic myeloid leukemia, Colitis #First and last authors equally contributed ...

Risk perception of cigarette and alcohol consumption: Korea and Cameroon public assessment views

Research Article of International Research Journal of Public Health Risk perception of cigarette and alcohol consumption: Korea and Cameroon public assessment views KyungHee Kim1,Tinyami Erick Tandi*1, 2,JaeWook Choi1, 3 1Institute for Occupational and Environmental Health, Korea University, Seoul, South Korea; 2Ministry of Public Health Yaounde, Yaoude Cameroon; 3Department of Preventive Medicine, College of Medicine, Graduate School of Public Health Korea University, Seoul South Korea. Introduction: There is a strong risk perception of personal knowledge on both cigarette-and alcohol-related harm. One possible factor contributing to this may be greater availability and access of cigarette and alcohol in the communities especially in developing settings. The causes of the difference in psychological factors that affect the public with high risk perception of cigarette and alcohol consumption was analysed. A higher perception of cigarette and alcohol availability is not only likely to increase supply but also to raise awareness of the different brands of alcohol, create a competitive local market that reduces product costs, and influence local social norms relating to cigarette and alcohol consumption. This paper assess risk perception with respect to the association between psychological paradigms of alcohol and cigarette use in both Korea and Cameroon nationwide. Methods: Using questionnaire survey a cross sectional study on risk perception regarding cigarette and alcohol consumption was assessed among some 2,181 men and 2,203 women from Korea and Cameroon who were over the age of 20 nationwide. Descriptive statistics were performed in order to analyse the sociodemographic characteristics of South Korea and Cameroon. Student’s t-test was performed to test the difference between risk perception and the psychometric paradigm. Correlational analysis was performed to analyse the relationship between risk perception and psychometric paradigm for each country. In order to analyse the components that affect risk perception, multivariate regression analysis was conducted. Results: The analysis results indicated ...

Determination of Microbiological quality and detection of Thermotolerant fecal E. coli in ready to use water from Navsari city of South Gujarat

Research Article of International Research Journal of Public Health Determination of Microbiological quality and detection of Thermotolerant fecal E. coli in ready to use water from Navsari city of South Gujarat A. P. Suthar, R. Kumar, C. V. Savalia, N. K. Patel and R. K. Patel Department of Veterinary Public Health and Epidemiology, College of Veterinary science & Animal Husbandry, Navsari Agricultural University, Navsari-396 450, Gujarat. India Fecal bacterial indicator analyses have been widely used for monitoring the water quality. The present study was designed to determine the density of Coliform and  Thermotolerant fecal E. coli from ready to use water samples collected  for a five month(from november-2016 to March-2017) period of monitoring from in and around Navsari city. A total of 73 samples were collected from different places and processed under standard bacteriological techniques. The EMB Agar was used as selective medium for isolation. The presumptive isolates of thermotolerant fecal E. coli were identified by Indole and Mac Conkey broth test (Acid & Gas) at 44°C  incubation and coliform were enumerated by MPN technique and E. coli were identified by metallic seen on EMB agar plate and biochemical test. Analysis of result revealed 11 isolates (15.06 %) (3 samples from Abrama village, 3 samples from fish market, 1 sample from PG hostel, 1 samples from Krishna hotel, 1 sample from Jay Ambe tea stall, 1 sample from Mahadev mandir and 1 sample from panipuri centre) of Thermotolerant fecal E. coli as well as E. coli  from 73  samples. All 11 isolates having presumptive number of coliform (MPN/100ml) ranging from 13-242 which may higher than the standard number which is below 10 according to BIS. The sensitivity pattern of Thermotolerant fecal E. coli with different antimicrobial agents was evaluated by D-test and showed cent percent resistant towards Amoxycilline followed in ...

Spatial and Temporal Level of Methane Gas from Some Dumpsites in Yenagoa Metropolis

Research Article of International Research Journal of Public Health Spatial and Temporal Level of Methane Gas from Some Dumpsites in Yenagoa Metropolis 1Tariwari C. N Angaye*, 1Elijah I. Ohimain and 2Donbebe Wankasi 1-Department of Biological Sciences, Niger Delta University, Wilberforce Island, Bayelsa State Nigeria. 2-Department of Chemical Sciences, Niger Delta University, Wilberforce Island, Bayelsa State Nigeria. The emission of methane from dumpsite have become a global mantra due to its remarkable effect on global climate change. This study assessed the levels of methane emissions from 6 dumpsites using portable air quality meter (AEROQUAL-Series 300). Results showed that the spatial level of methane ranged from 1.00 - 6.44 ppm. Based on temporal variation level of methane ranged from 1.59 – 4.09 ppm (p<0.05), with higher values in wet season. Meanwhile methane emission was not detected in the control station. Based on model for Air Quality Index (AQI), methane emission were predominantly rated as safe and moderate, except for stations LE and LF. Notwithstanding, these results confirmed the emission of methane from the dumpsite due to anthropogenic activities. We therefore recommend policies aimed at sequestration methane emissions, including the reuse, recycling and reduction of waste stream. Keywords: Methane, Dumpsite, Waste stream, anthropogenic activities ...

Malaria infection among persons patronizing drugstores for malaria treatment in Port Harcourt and its environs Rivers, State Nigeria

Research Article of International Research Journal of Public Health Malaria infection among persons patronizing drugstores for malaria treatment in Port Harcourt and its environs Rivers, State Nigeria Augustine- D’Israel, E. and Abah, A.E Department of Animal and Environmental Biology, Faculty of Science, University of Port Harcourt, PMB 5323 Port Harcourt 50001, Rivers State, Nigeria. Background: Malaria continues to be of grave concern, despite all efforts geared towards its control and so remains a public health dilemma in Nigeria. Objectives: The aim of this study was to determine the occurrence of malaria among persons patronizing drugstores for malaria treatment in Port Harcourt and its environs, Rivers State, Nigeria. Methods: Ethical clearance was obtained and samples were randomly collected from 24 drug stores in three different locations and analyzed using both microscopy and rapid diagnostic techniques. Results: Out of 663 participants, 151(22.78%) were positive for Plasmodium falciparum. None was positive for P. Vivax. Preponderance by location showed that out of 221 sampled in each location, Mile IV (Rumueme) 68(30.77%), Rumuosi had 51(23.08%) and D/Line area 32(14.48%). The occurrence of malaria in the study area was significantly different (X2 = 16.69; p = 0.001). Out of the 151 positive cases, 134 (88.0%) had an intensity level of 1,000 parasites/µl, 16 (10.6%) had an intensity level of 1000-9999 parasites/µl and only 1(0.71%) had an intensity level of ≥10,000parasites/µl (0.71%). (X2 = 2.58; P = 0.275). This implies that majority of those patronizing drugstores for malaria treatments do not have severe malaria. In conclusions: The occurrence of malaria among the study group is high. There was a significant difference in the occurrence of malaria across the three study areas. Therefore, the populace should be encouraged to step up their practice on malaria prevention and control. Keywords:Malaria; Occurrence; drugstores; treatment; patronage ...

A traditional formulation of Shorea robusta resin found effective in excision wound model in rats

Research Article of International Journal of Traditional and Complementary Medicine A traditional formulation of Shorea robusta resin found effective in excision wound model in rats Shrijana Shakya and Deepak Bashyal Department of Pharmacy, Institute of Medicine A large proportion of the population of developing countries still uses traditional medicines, either as a result of the high cost of Western pharmaceuticals and health care, or because the traditional medicines are more acceptable from a cultural and spiritual perspective(1). The WHO estimates nearly 80% of the population still depends upon herbal medicines due to their easy availability, low cost and possible less side effects as compared to allopathic system of medicines(2). These also cover healthcare systems that include beliefs and practices relating to diseases and health, which are products of indigenous cultural development and are not explicitly derived from a conceptual framework of modern medicine. Ingredients used in the preparation of those remedies may even provide attractive templates for the development of new pharmaceutical products(3). All the people of Nepal have no access to allopathic medicine and health center because of illiteracy, poverty and unavailability. Thus, about 80% of the population in Nepal relies on traditional medicine(4). One such example is the use of formulation containing Shorea robusta resin, prepared by local practitioners themselves, for treating infected wounds and burns by some locals in Kathmandu valley. The ingredients used in traditional medicine, therefore, must be recognized and studied, not only as therapeutic agents with verifiable pharmacodynamic properties, but as agents of healing with beneficial effects, even when the precise mode of activity has not been properly understood(3). Keywords: Antifungal evaluation, Plant extracts, Phytochemicals, Nigerian medicinal plants, Botanical description, Constituuents,Euphorbia hirta, Ficus asperifolia, Momordica charantia, Nicotiana tabacum and Spondias mombin ...