Research Journal of Pharmacology and Pharmacy

Insulin response of methanol fraction of Hensia crinita extract

Research Article of Research Journal of Pharmacology and Pharmacy Phytochemical profiling, oral glucose tolerance, body weight changes and insulin response of methanol fraction of Hensia crinita extract on Wistar Rats Iwara A. Iwara*, Godwin O. Igile, Eyong Ubana Eyong, John M. Edward, Collins Igajah and Patrick .E. Ebong Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P.M.B 1115, Calabar, Nigeria. Phytochemical profiling, oral glucose tolerance, body weight changes and insulin response fraction of Hensia crinita (H.C) leave extract was investigated in this study. Using  Gas Chromatography –mass spectrometry (GC-MS) analytical method for phytochemicals analysis, the methanol fraction of H.C showed the presence of fourteen compounds and revealing with respect to percentage abundance, high levels of Oleic acid (27.13%), Hexadecanoic acid (11.5%), ethylbenzene(9.92%), nonane (9.85%), 7-oxalic{4.1.0}heptane (9.83%), 1,2,3-trimethylbenzene (8.05%), Oxalic acid (7.42%)  as well as other compounds. Body weight showed significant increase (P<0.05) treated groups when compared to the control. Oral glucose tolerance level was also increased in the extract treated groups. A significant increase (P<0.05) in serum insulin level was observed in extract treated compared to diabetic control. Both ethanol crude extract and methanol fraction showed positive responses to oral glucose test, body weight changes and insulin levels activity and therefore may be incorporated in herbal decoctions in the management of diabetes. Keywords: Phytochemical, antidiabetic, Oleic acid, Hensia crinita ...

Xylanase on feed efficiency and serum biochemistry in broilers

Research Article of Research Journal of Pharmacology and Pharmacy Effect of supplementation of xylanase on feed efficiency and serum biochemistry in broilers) Abida Niazi1, Amber Khan1, Zunaira Alina2, 3, Anam Asghar3, Bushra Ishfaq 3, Shaneel Kousar2, Laiba Riaz2, Ramsha Abbas2, Faiza Naseer*3 1University of Veterinary and Animal Sciences Lahore, Pakistan 2Institue of pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan 3Department of Pharmacy, Government College University Faisalabad, Pakistan To study the working mechanisms for non-starch polysaccharides’ to improve the growth performance of broiler chickens, a 35-day feeding trial was conducted. Two dietary treatments were included: 1) wheat diet (the control); 2) wheat+xylanase diet .There were 5  groups with 3 replicates ,each replicates having 8 birds each for each treatment and the experimental diets were given to birds from hatch.  Group A was control and group B was treated with Xylanase concentration of 250IU/Kg feed, Group C was treated with Xylanase concentration of 500IU/Kg feed, Group D was treated with Xylanase concentration of 750IU/Kg feed and Group E was treated with Xylanase concentration of 1000IU/Kg feed.FCR and body weight were measured weekly. The vaccination was done according to schedule. Fresh Water provided at free labitum. The shed was properly maintained with respect to temperature and humidity. The Fumagination was properly and thoroughly done before the start of experiment. The xylanase supplement increased (p<0.05) body weight gain (BWG) and improved feed conversion ratio (FCR) at the end of the experiment but non-significant results were observed on serum biochemistry (p>0.05) by xylanase. (Key Words: Xylanase, weight gain, Serum biochemistry. Keywords: Xylanase, weight gain, Serum biochemistry ...

Acute toxicity, anti-inflammatory and analgesic effects of Dilleniaceae

Research Article of Research Journal of Pharmacology and Pharmacy Acute toxicity, anti-inflammatory and analgesic effects of aqueous extract of Tetracera alnifoliaWilld. (Dilleniaceae) Nsonde Ntandou GF a,b*, BoumbaL.S.b,d,  Gouollaly T.c,d,Makambila M.C.d, Ouamba J.M.c,  Abena A.A. a Laboratoire de Biochimie et Pharmacologie, Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, B.P. 69, Congo Laboratoire de Physiologie et Physiopathologie Animales, Faculté des Sciences et Techniques, Université Marien NGOUABI, Brazzaville, BP 69, Congo Unité de Chimie du Végétal et de la Vie, Faculté des Sciences, Université Marien NGOUABI, Brazzaville, B.P. 69, Congo Institut National de Recherche en sciences de la Santé, Cité Scientifique (ex-ORSTOM), Route de l’Auberge de Gascogne, Makélékélé, Brazzaville- Congo. This work is part of the valorization of the traditional use of Tetracera alnifolia (Dilleniaceae). In this study we evaluated acute toxicity, anti-inflammatory and analgesic effects in rodent, and chemically screened its aqueous leaves extract. The phytochemical classic tests allowed to identify his various chemical families. Standard procedures by using OECD Guideline were followed to evaluate toxicity in mice. To assess anti-inflammatorythe carrageneen induced paw oedema and the pellet of cotton were used. Acetic acid and rat paw pressure methods served for the evaluation of the analgesic. This plant is very rich in flavonoids, cardiotonic heterosids and saponosides, and rich in alkaloids, steroids, terpenoides and tannins. Leaves aqueous extract is considered low-toxic with an LD50 greater than 2000 mg / kg. At this dose the extract exhibits signs of toxicity inclunding dyspnea and motor impairment. At the doses of 200 and 400 mg/kg the extract showed a significant effect on carrageenan-induced edema (p< 0.001), acetic acid induced abdominal cramps (p< 0.001) and on the nociceptive freshold(p< 0.001) and latency response of paw pressure (p< 0.001). These effects are due to presences of its secondary metabolites. This pharmacological results confirm the ...

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Research Journal of Pharmacology and Pharmacy

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1. Avinaba Mukherjee, Sourav Sikdar, Anisur Rahman Khuda-Bukhsh. Evaluation of ameliorative potential of isolated flavonol fractions from Thuja occidentalis in lung cancer cells and in Benzo(a) pyrene induced lung toxicity in mice. International Journal of Traditional and Complementary Medicine, 2016; 1(1): 0001-0013. 
2. Vikas Gupta, Parveen Bansal, Junaid Niazi, Kamlesh Kohli, Pankaj Ghaiye. Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice-A Preclinical Study. Journal of Herbal Medicine Research, 2016; 1(1): 0001-0006.

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Dr. B. Thangagiri
Assistant Professor (Senior Grade), Department of Chemistry, Mepco Schlenk Engineering College

Dr. Kaptain Kishor Bajpayee
Associate Professor & Head, Center for Research in Ethno & Medicobotany, Dr. R.M.L. Degree College (C.S.J.M. UNIVERSITY )Allipur, HARDOI 241001 INDIA.

Dr. Dhruba Pathak
The University of Tennessee Health Science Center, 855 Monroe Avenue, Suite 515, Memphis, TN 38163

Dr. Tauqeer Hussain Mallhi
School Of Pharmaceutical Sciences, Usm, Penang, Malaysia

Dr. Hamzah Maswadeh
Associate Prof. Head of Department of Pharmaceutics College of Pharmacy – Qassim University -KSA

Dr. Theophine Akunne
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Nigeria

Dr. Kasim S. Abass
Assistant Professor, College of Nursing, University of Kirkuk

Dr Yusra Habib Khan
University Sains Malaysia

Dr Charles Fokunang
Professor& Director of Student’ Affairs, The University of Bamenda; Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon.

Dr. Gelase Fredy Nsonde Ntandou
Faculty of Science and Technology, Marien NGOUABI University