Research Journal of Pharmacology and Pharmacy

Acute toxicity, anti-inflammatory and analgesic effects of Dilleniaceae

Research Article of Research Journal of Pharmacology and Pharmacy Acute toxicity, anti-inflammatory and analgesic effects of aqueous extract of Tetracera alnifoliaWilld. (Dilleniaceae) Nsonde Ntandou GF a,b*, BoumbaL.S.b,d,  Gouollaly T.c,d,Makambila M.C.d, Ouamba J.M.c,  Abena A.A. a Laboratoire de Biochimie et Pharmacologie, Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, B.P. 69, Congo Laboratoire de Physiologie et Physiopathologie Animales, Faculté des Sciences et Techniques, Université Marien NGOUABI, Brazzaville, BP 69, Congo Unité de Chimie du Végétal et de la Vie, Faculté des Sciences, Université Marien NGOUABI, Brazzaville, B.P. 69, Congo Institut National de Recherche en sciences de la Santé, Cité Scientifique (ex-ORSTOM), Route de l’Auberge de Gascogne, Makélékélé, Brazzaville- Congo. This work is part of the valorization of the traditional use of Tetracera alnifolia (Dilleniaceae). In this study we evaluated acute toxicity, anti-inflammatory and analgesic effects in rodent, and chemically screened its aqueous leaves extract. The phytochemical classic tests allowed to identify his various chemical families. Standard procedures by using OECD Guideline were followed to evaluate toxicity in mice. To assess anti-inflammatorythe carrageneen induced paw oedema and the pellet of cotton were used. Acetic acid and rat paw pressure methods served for the evaluation of the analgesic. This plant is very rich in flavonoids, cardiotonic heterosids and saponosides, and rich in alkaloids, steroids, terpenoides and tannins. Leaves aqueous extract is considered low-toxic with an LD50 greater than 2000 mg / kg. At this dose the extract exhibits signs of toxicity inclunding dyspnea and motor impairment. At the doses of 200 and 400 mg/kg the extract showed a significant effect on carrageenan-induced edema (p< 0.001), acetic acid induced abdominal cramps (p< 0.001) and on the nociceptive freshold(p< 0.001) and latency response of paw pressure (p< 0.001). These effects are due to presences of its secondary metabolites. This pharmacological results confirm the ...

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Research Journal of Pharmacology and Pharmacy

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1. Avinaba Mukherjee, Sourav Sikdar, Anisur Rahman Khuda-Bukhsh. Evaluation of ameliorative potential of isolated flavonol fractions from Thuja occidentalis in lung cancer cells and in Benzo(a) pyrene induced lung toxicity in mice. International Journal of Traditional and Complementary Medicine, 2016; 1(1): 0001-0013. 
2. Vikas Gupta, Parveen Bansal, Junaid Niazi, Kamlesh Kohli, Pankaj Ghaiye. Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice-A Preclinical Study. Journal of Herbal Medicine Research, 2016; 1(1): 0001-0006.

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Dr. B. Thangagiri
Assistant Professor (Senior Grade), Department of Chemistry, Mepco Schlenk Engineering College

Dr. Kaptain Kishor Bajpayee
Associate Professor & Head, Center for Research in Ethno & Medicobotany, Dr. R.M.L. Degree College (C.S.J.M. UNIVERSITY )Allipur, HARDOI 241001 INDIA.

Dr. Dhruba Pathak
The University of Tennessee Health Science Center, 855 Monroe Avenue, Suite 515, Memphis, TN 38163

Dr. Tauqeer Hussain Mallhi
School Of Pharmaceutical Sciences, Usm, Penang, Malaysia

Dr. Hamzah Maswadeh
Associate Prof. Head of Department of Pharmaceutics College of Pharmacy – Qassim University -KSA

Dr. Theophine Akunne
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Nigeria

Dr. Kasim S. Abass
Assistant Professor, College of Nursing, University of Kirkuk

Dr Yusra Habib Khan
University Sains Malaysia

Dr Charles Fokunang
Professor& Director of Student’ Affairs, The University of Bamenda; Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon.

Dr. Gelase Fredy Nsonde Ntandou
Faculty of Science and Technology, Marien NGOUABI University