Research Journal of Pharmacology and Pharmacy


Acute toxicity, anti-inflammatory and analgesic effects of Dilleniaceae

Research Article of Research Journal of Pharmacology and Pharmacy Acute toxicity, anti-inflammatory and analgesic effects of aqueous extract of Tetracera alnifoliaWilld. (Dilleniaceae) Nsonde Ntandou GF a,b*, BoumbaL.S.b,d,  Gouollaly T.c,d,Makambila M.C.d, Ouamba J.M.c,  Abena A.A. a Laboratoire de Biochimie et Pharmacologie, Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, B.P. 69, Congo Laboratoire de Physiologie et Physiopathologie Animales, Faculté des Sciences et Techniques, Université Marien NGOUABI, Brazzaville, BP 69, Congo Unité de Chimie du Végétal et de la Vie, Faculté des Sciences, Université Marien NGOUABI, Brazzaville, B.P. 69, Congo Institut National de Recherche en sciences de la Santé, Cité Scientifique (ex-ORSTOM), Route de l’Auberge de Gascogne, Makélékélé, Brazzaville- Congo. This work is part of the valorization of the traditional use of Tetracera alnifolia (Dilleniaceae). In this study we evaluated acute toxicity, anti-inflammatory and analgesic effects in rodent, and chemically screened its aqueous leaves extract. The phytochemical classic tests allowed to identify his various chemical families. Standard procedures by using OECD Guideline were followed to evaluate toxicity in mice. To assess anti-inflammatorythe carrageneen induced paw oedema and the pellet of cotton were used. Acetic acid and rat paw pressure methods served for the evaluation of the analgesic. This plant is very rich in flavonoids, cardiotonic heterosids and saponosides, and rich in alkaloids, steroids, terpenoides and tannins. Leaves aqueous extract is considered low-toxic with an LD50 greater than 2000 mg / kg. At this dose the extract exhibits signs of toxicity inclunding dyspnea and motor impairment. At the doses of 200 and 400 mg/kg the extract showed a significant effect on carrageenan-induced edema (p< 0.001), acetic acid induced abdominal cramps (p< 0.001) and on the nociceptive freshold(p< 0.001) and latency response of paw pressure (p< 0.001). These effects are due to presences of its secondary metabolites. This pharmacological results confirm the ...

About the journal
The journal is hosted by eSciPub LLC. Our aim is to provide a platform that encourages publication of the most recent research and reviews for authors from all countries.


About the publisher
eSciPub LLC is a publisher to support Open Access initiative located in Houston, Texas, USA. It is a member of the largest community of professional publishers in the United States: the Independent Book Publishers Association. It hosts more than 100 Open Access journals in Medicine, Business & Economics, Agriculture, Biological Sciences, Chemistry, Education, Physical Sciences, Sociology, and Engineering and Technology.


Rapid Response Team
Please feel free to contact our rapid response team if you have any questions. Our customer representative will answer your questions shortly.

Research Journal of Pharmacology and Pharmacy

Manuscript Title: The title should be a brief phrase.

Author Information: List full names and affiliation of all authors, including Emails and phone numbers of corresponding author.

Abstract: The abstract should be less than 500 words. Following abstract, a list of keywords and abbreviations should be added. The keywords should be no more than 10. Abbreviation are only used for non standard and long terms.

Introduction: The introduction should included a clear statement of current problems.

Materials and Methods: This section should be clearly described.

Results and discussion: Authors may put results and discussion into a single section or show them separately.

Acknowledgement: This section includes a brief acknowledgment of people, grant details, funds

References: References should be listed in a numbered citation order at the end of the manuscript. DOIs and links to referenced articles should be added if available. Abstracts and talks for conferences or papers not yet accepted should not be cited. Examples Published Papers: 

1. Hongmei YANG. A study on the Management Mode of Modern Vocational Education in China. Global journal of Economics and Business Administration, 2018, 3: 10.DOI: 10.28933/gjeba-2018-07-2301 

Tables and figures: Tables should be used at a minimum with a short descriptive title. The preferred file formats for Figures/Graphics are GIF, TIFF, JPEG or PowerPoint.

Publication fees: We do not charge any submission charges, but authors are required to pay publication fees after their manuscripts are accepted for publication. For authors who receive our invitations, please send us the invitation code to receive the special discount.

Proofreading and Publication: A proof will be sent to the corresponding author before publication. Authors should carefully read the proof to avoid any errors and return the proof to the editorial office. Editorial office will publish the article shortly.

Withdrawal Policy: When you want to withdraw an article, please contact us. We will withdraw/retract it from our system after reviewing your request.

Terms of Use/Privacy Policy/Disclaimer/Other Policies: you agree that by using or receiving our services, you have read, understood, and agreed to be bound by all of our terms of use/privacy policy/ disclaimer/ other policies.

Loading