Editorial Board of Global Journal of Molecular Biology
Dr. Richa Madan Lomash
Receptor Biology Unit (NINDS), NIH, Bethesda (MD), USA
Biography & Research Interest
Welcome Dr. Richa Madan Lomash to Join the Editorial Board of Global Journal of Molecular Biology.
My research has focused on understanding the basic functioning of the intracellular transport machinery. I have been researching in this area for over 10 years and have contributed towards characterizing new players involved as well as understanding the mechanisms of the intracellular transport process. In my doctoral research, I demonstrated a novel pathway by which the intracellular pathogen Salmonella modulates the host’s cellular machinery to their advantage. I demonstrate how the Salmonella effector protein, SipC interacts with host SNARE, Syntaxin6, and modulates the composition of the Salmonellacontaining phagosome via fusion with Golgi-derived vesicles thus, recruiting LAMP1 on phagosomes to stabilize this specialized compartment for efficient intracellular survival. During my postdoctoral training, I decided to use my past training and experience towards understanding the complex and fascinating mechanisms underlying receptor trafficking in the nervous system. As part of that, I have identified and characterized neurolastin (RNF112/Znf179) as a novel brain-specific dynamin-family GTPase with E3 ligase activity. I demonstrate that neurolastin plays an important role in regulating endosome size, spine density and synaptic transmission. My recent results show that neurolastin is present on the mitochondria and important for maintaining mitochondrial structure. Currently, I am working to understand how neurolastin is involved in maintaining mitochondrial membrane dynamics. In addition to this, I have demonstrated a molecular mechanism that regulates trafficking of glutamate receptors (GluK1) to the synapses via phosphorylation of its auxiliary subunit, Neto2.
1) Lomash RM, Sheng N, Li Y, Nicoll RA, Roche KW. Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at Serine 409 regulates synaptic targeting of the KAR subunit GluK1. J Biol Chem. 2017
2) Sheng N, Shi YS, Lomash RM, Roche KW, Nicoll RA. Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1. Elife. 2015
3) Lomash RM, Gu X, Youle RJ, Lu W and Roche KW. Neurolastin, a dynamin family GTPase, regulates excitatory synapses and spine density. Cell Rep. 2015
4) Madan R, Rastogi R, Parashuraman S and Mukhopadhyay A. SipC recruits host Syntaxin6 on Salmonella-containing phagosomes to acquire LAMP1 from Golgi. J Biol Chem. 2012
5) Parashuraman S*, Madan R* and Mukhopadhyay A. NSF independent fusion of SalmonellaContaining Late Phagosomes with Early Endosomes. FEBS Lett. 2010
6) Bhattacharya M, Ojha N, Solanki S, Mukhopadhyay CK, Madan R, Patel N, Krishnamurthy G, Kumar S, Basu SK, Mukhopadhyay A. IL-6 and IL-12 specifically regulate the expression of Rab5 and Rab7 via distinct signaling pathways. EMBO J, 2006
Reviews and book chapters
1) Madan R, Krishnamurthy G, and Mukhopadhyay A. SopE-mediated recruitment of host Rab5 on phagosomes inhibits Salmonella transport to lysosomes. Methods in Molecular Biology 2008