The Possible Effects of Asiatic Herbs in SARS-COV-2 and their Mechanism of Action

Ferro M.*, Graubard A., Ledezma R., Escalante P., Channan G., Dotres V. and Bencomo Y.

Department of Sciences, Nutrition Formulators Inc., Miramar, Fl, USA.

In 2019, a new virus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) gave rise to an unknown outbreak that spread in China’s Hubei province, triggering a new epidemic
known as coronavirus-19 (COVID -19). Several studies have demonstrated the metabolic pathways of SARS-COV-2 in angiotensin-converting enzyme receptors 2 (ACE2). With this, others have been considering an approach with drugs that bind to ACE2 receptors as well as antiviral activity as a possible treatment option for the disease. Thus, the objective of this present review was to evaluate some Asiatic herbs for both the prevention and treatment of COVID-19. Some herbs, such as the extract of Artemisia annua (Artemisinins) and the extract of Isatis
indigotica (Emodin), showed to be effective as inhibitors of adhesion of some viruses. Some studies observed this in the SARS-CoV S / ACE -2 protein interaction in which it inhibited the adhesion of the virus to the cell surface. Similarly, Glycyrrhiza glabra extract (Licorice) showed significant inhibiting action on the influenza virus and was shown to be an effective antiviral in many other viruses by weakening virus activity, such as inhibiting virus gene expression and replication, reducing adhesion force and stress through the reduction of high-mobility-group box1 (HMGB1) binding to DNA. Additionally, one of the best herbs in effective concentration value (EC50) found in this study was Lycoris Radiata with EC50: 2,4 ± 0.2 μg / ml. The results presented in this review are promising in the search for prophylactic treatment in a viral pandemic such as SARS-VOC-2. However, more clinical trials to validate the processes of the effectiveness of both plants and their extracts, as well as the synergy between the plants themselves are needed to validate future herbal treatments against SARS-VOC-2.

Keywords: SARS-COV-2; ACE2; COVID-19; Asiatic Herbs

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Ferro M., Graubard A., Ledezma R., Escalante P., Channan G., Dotres V. and Bencomo Y.. The Possible Effects of Asiatic Herbs in SARS-COV-2 and their Mechanism of Action. American Journal of Anatomy and Physiology, 2021; 4:15. DOI:10.28933/ajap-2020-12-0305


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