CYTOTOXICITY ASSESSMENT AND ANTIMICROBIAL ACTION OF Caulerpa taxifolia (M. Vahl) C.


CYTOTOXICITY ASSESSMENT AND ANTIMICROBIAL ACTION OF Caulerpa taxifolia (M. Vahl) C.


Evandro Valentim da Silva¹*; Gabriela Cavalcante da Silva²; Wanesca Alves da Silva³; Lívia Nara Eugênio Pereira³; Fálba Bernadete Ramos dos Anjos4; Ivone Antônia de Souza5.

1Doutorando em Ciências Farmacêuticas – UFPE; 2Doutoranda em Bioquímica e Fisiologia – UFPE; 3Graduanda em Ciências Farmacêuticas – UFPE; 4Departamento de Histologia e Embriologia – UFPE; 5Departamento de Antibióticos – UFPE


American Journal of Biotechnology and Bioscience

This study aims to determine the LC50 for Artemia salina Leach and perform a microbial screening two C. taxifolia extracts. In these biological assays have been used larvae of A. salina Leach ob-tained from the incubation of about 20 mg of A. salina cysts, under artificial light for 48 hours. Where groups of 10 metanauplius were exposed to different concentrations (50 mg / mL to 1000 ug / ml) of methanol extract and hydroalcoholic C. taxifolia . The antimicrobial activity of extracts of C. taxifolia was evaluated by diffusion method in paper disc. The percentage mortality deter-mined after 24 hours of contact. Through the data was calculated LC50. Behavioral analysis of Artemia salina Leach showed a decrease in handling compared to those observed in the control groups. The microbial activity of the extracts were evaluated by measuring the halo of inhibition for two species of gram-positive and two gram-negative bacteria. The extracts showed signifi-cant results for S. aureus and S. spp. This study demonstrates that C. taxifolia has a high cyto-toxicity suggested that its use in cell culture as a molluscicide and can be used in the production of production of antimicrobial drugs.


Keywords:  Artemia salina, microbiology, Staphylococcus aureus, Streptococcus spp.

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How to cite this article:
Evandro Valentim da Silva; Gabriela Cavalcante da Silva, Wanesca Alves da Silva; Lívia Nara Eugênio Pereira; Fálba Bernadete Ramos dos Anjos; Ivone Antônia de Souza.CYTOTOXICITY ASSESSMENT AND ANTIMICROBIAL ACTION OF Caulerpa taxifolia (M. Vahl) C. American Journal of Biotechnology and Bioscience, 2019; 3:11. DOI: 10.28933/ajbb-2019-05-1206


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