Research Article of American Journal of Cardiology Research and Reviews
Chemotherapy-induced cardiotoxicity: Preliminary report from a tertiary cancer centre in India
Dr Suwarna Tambade MBBS, DNB- Medicine,
Dr Sagar Bhalerao MBBS MD Oncology,
Dr Rucha Sule MBBS, MD Psychiatry
Dr Rajnish Nagarkar MS, MRCS (Edin), DNB BSS (UK), MNAMS
HCG Manavata Cancer Centre, Nashik, India.
Cancer has emerged as a major public health issue in India owing to significant epidemiological and demographic transition. As per literature, the overall ten-year survival rate for cancer is at 50% across the 20 most common malignancies. However, the ten-year survival rate is even more high, i.e. approximately 80% or higher for breast, melanoma, lymphoma, and uterine cancers. Contrary to the improved long-term cancer survival rates there has been an increase in adverse cardiac effects of cancer treatment. A retrospective analysis of patients admitted at HCG Manavata Cancer Centre, Nashik was conducted. The study was conducted at a single center comprising of 115 participants. Anthracyline chemotherapy has remained a mainstay treatment approach for cancer patients. Cardiotoxic side-effects of anthracyline chemotherapy regimens often limits their dosing. Although anthracylines have been associated with improved cancer outcomes, there remains an increased risk of cardiovascular morbidity and mortality. Doxorubicin-induced cardio toxicity was 5.45% while trastuzumab cardio toxicity was 5.26% (Table 4). The estimated cardio toxicity rate for our two-year follow-up was 4.08% for all specified chemotherapy regimens. The early detection of cardio toxicity by appropriate follow-up and monitoring is essential. Evaluation of patients using LVEF as a key parameter would help prevent irreversible cardio toxic events. Our preliminary report may act as a base for researchers and academicians to conduct and review ongoing chemotherapy regimens.
Keywords: Chemotherapy-induced cardiotoxicity, Preliminary report, Tertiary cancer centre, India
How to cite this article:
Suwarna Tambade, Sagar Bhalerao, Rucha Sule, Rajnish Nagarkar. Chemotherapy-induced cardiotoxicity: Preliminary report from a tertiary cancer centre in India.American Journal of Cardiology Research and Reviews, 2018, 1:7. DOI:10.28933/ajcrar-2018-10-0501
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