Review Article of American Journal of Cardiology Research and Reviews
INDUCTION OF EXPERIMENTAL TROMBOSES IN ANIMAL MODEL
Arthur Hipólito Pereira Leite1*, Adriana Maria da Silva Telles2, Ana Lúcia Figueiredo Porto3
Introduction: In vivo studies, related to thrombosis, allow a better understanding of the biological behavior of molecules with thrombolytic properties. Goal: To evaluate the methodological characteristics as well as the efficacy of thrombosis induced by the association of the blood stasis method and ferric chloride (FeCl3). Methodology: Review of published literature on the topic “Experimental thrombosis”. This search was performed in the Pubmed, ScieceDirect, Scielo and Google Academic databases, by crossing the following descriptors: Thrombosis, Fibrinolytics and Cardiovascular Diseases. Articles, dissertations and theses written in Portuguese and English were selected without delimitation of the date of publication. Results: National and international studies have shown that the induction of thrombosis, by association of the methods mentioned above, is simple, cheap and reproducible. In addition, this combination of techniques allows adequate mimicking of the thrombogenic characteristics observed in humans. Conclusion: Studies in biological models are essential for understanding the mechanisms involved in thrombotic disorders.
Keywords: Cardiovascular diseases, Fibrinolytics, Thrombosis.
How to cite this article:
Arthur Hipólito Pereira Leite, Adriana Maria da Silva Telles, Ana Lúcia Figueiredo Porto. INDUCTION OF EXPERIMENTAL TROMBOSES IN ANIMAL MODEL.American Journal of Cardiology Research and Reviews, 2019, 2:8. DOI:10.28933/ajcrar-2019-10-1005
1. Ruppert A, Lees M, Steinle T. Clinical burden of venous thromboembolism. Current Medical Research and Opinion, v. 26, n. 10, 2010.
2. Zhang X, Yun L, Peng L .Optimization of Douchi fibrinolytic enzyme production by statistical experimental methods. Journal of Huazhong University of Science and Technology. Medical sciences, v. 33, n. 1, 2013.
3. Raafata AL, Arabyb E, Lotfya S. Enhancement of fibrinolytic enzyme production from Bacillus subtilis via immobilization process onto radiation synthesized starch/dimethylaminoethyl methacrylate hydrogel. Carbohydrate Polymers, v.87, 2012.
4. Reyes I, Mussoni L, Donatti MB, Gaetano G. Failure of aspirin at different doses to modify experimental thrombosis in rats. Thrombosis Research, v. 18, n. 5, 1980.
5. Misra A, Prakash P, Aggarwal H. Anti-thrombotic efficacy of S007-867: pre-clinical evaluation in experimental nmodels of thrombosis in vivo and in vitro. Biochemical Pharmacology, doi: https://doi.org/10.1016/j.bcp.2018.01.013, 2018.
6. Yoshida WB. Tratamento convencional da trombose venosa profunda proximal: ainda uma boa opção? Jornal Vascular Brasileiro, v. 15, n. 1, 2016.