Clinical and Histopathological Findings in Patients with Follicular Dermatoses: All Skin Diseases Starts in the Hair Follicles as New Hypothesis


Clinical and Histopathological Findings in Patients with Follicular Dermatoses: All Skin Diseases Starts in the Hair Follicles as New Hypothesis


*Professor Khalifa E. Sharquie MD,PhD,FRCP Edin, *Professor Adil A. Noaimi MD, DDV, FICMS, **Dr. Rusul A. Flayih MD.

*Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq.
** Center of Dermatology; Baghdad Teaching Hospital; Medical City, Baghdad, Iraq.


American Journal of Clinical Research and Reviews

Background: Follicular dermatoses are group of skin diseases characterised by follicular lesions during the course of the disease.

Objective: To gather all skin diseases where there is follicular lesions to be evaluated in order to reach the hypothesis that hair follicles are the most principal target area in the etiopathogenesis of these skin disorders.

Patients and Methods: This is a descriptive, clinical and histopathological study that was carried out at the Department of Dermatology, Baghdad Teaching Hospital, Medical City, and Baghdad, Iraq during the period from November 2018 to August 2019. Sixty patients with different follicular dermatoses were enrolled and all socio- demographic data related to the disease was obtained from each patient, in addition to physical examination was performed for each patient. Biopsies were taken from 40 patients, for histopathological evaluation.

Results: Sixty patient, were included in this study, 35 patients males and 25 patients females with male to female ratio 1.4:1. Their ages ranged from 1-80(30.2 ± 16.96) years. All patients had follicular lesions. The histopathological results showed: perifollicular lymphocytes, follicular invasion and degeneration, follicular plugging, fibrous tract remnant, perifollicular melanophages and absent melanin pigment in the epidermis of patients with vitiligo.

Conclusion: The result of the present study showed that all skin diseases start in the hair follicles and might spread to involve the proper epidermis, and the lesions could be microscopic or visible to the naked eye. The hair follicles have many anatomical and immunological privileges that make it easy to be an early target for any cutaneous pathological process. Hence these findings are in support of new hypothesis that say: all skin diseases starts in the hair follicles and then spread to attack the adjacent proper epidermis


Keywords: follicular dermatoses, hair follicle, immunological privilege

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How to cite this article:
Khalifa E. Sharquie, Adil A. Noaimi, Rusul A. Flayih. Clinical and Histopathological Findings in Patients with Follicular Dermatoses: All Skin Diseases Starts in the Hair Follicles as New Hypothesis. American Journal of Clinical Research and Reviews, 2020; 4:17. DOI:10.28933/ajcrr-2020-04-2006


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