RIPARIN II POSSES ANTIDEPRESSANT-LIKE EFFECT AND REDUCES NEUROINFLAMATION IN MICE SUBMITTED TO CHRONIC UNPREDICTABLE MILD STRESS


RIPARIN II POSSES ANTIDEPRESSANT-LIKE EFFECT AND REDUCES NEUROINFLAMATION IN MICE SUBMITTED TO CHRONIC UNPREDICTABLE MILD STRESS


Alana Gomes de Souza1 *, Iardja Stéfane Lopes Sales1, José Tiago Valentim1, Dilailson Carlos Costa Júnior1, Francisca Cléa Florenço de Sousa1, Marta Maria de França Fonteles1

1Federal University of Ceará.


Introduction: Depression is a common and disabling disorder and stress is considered one of the main factors involved in its etiology. Many patients treated with conventional antidepressants do not respond adequately to treatment, so the development of new drugs is relevant.

Objective: To evaluate the effect of riparin II on the immobility time in the forced swimming test and on the cytokines’ levels in the hippocampus of mice submitted to Chronic Unpredictable Mild Stress.

Methods: Male mice (19-25g) were divided into three groups: control(1), stressed(2), stressed+riparin II(3) and stressed+fluoxetine(4). Groups 2, 3 and 4 were subjected to 28 days of exposure to unpredictably applied stressors. From the 14th day, groups 2 and 3 were treated with riparin II and fluoxetine, respectively (oral). On the 28th day, the animals were euthanized and the brain areas were removed for the measurement of cytokines (Interceucin1-β and Tumor Necrosis Factor).

Results: Immobility time and cytokine levels were increased by chronic stress, compared to control animals. Treatment with riparin II decreased these parameters, compared to the stressed group. [Forced Swimming: F (3, 30)= 15.80; 1vs2: p=0.0002, 2vs3: p=0.0002, 2vs4: p<0.0001; Interleukin1-β: F (3, 27)= 32.07; 1vs2: p<0.0001, 2vs3: p<0.0001, 2vs4: p=0.0111; Tumor Necrosis Factor: F (3, 28)= 18.91; 1vs2: p<0.0001, 2vs3: p=0.0008, 2vs4: p=0.0491].

Conclusion: Riparin II has antidepressant-like effect in mice, which may have as mechanism the reducing neuroinflammation, thus showing itself as a promising substance for further studies in the treatment of depressive disorders.


Keywords: Chronic stress, Depression, Neuroinflammation.

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How to cite this article:

Alana Gomes de Souza, Iardja Stéfane Lopes Sales, José Tiago Valentim, Dilailson Carlos Costa Júnior, Francisca Cléa Florenço de Sousa, Marta Maria de França Fonteles.RIPARIN II POSSES ANTIDEPRESSANT-LIKE EFFECT AND REDUCES NEUROINFLAMATION IN MICE SUBMITTED TO CHRONIC UNPREDICTABLE MILD STRESS. American Journal of Microbiology and Immunology, 2021, 6:12. DOI: 10.28933/ajmi-2021-03-2005


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