Research Article of American Journal of Microbiology and Immunology
IMPACTS OF IMMUNOSUPPRESSION ON THE GRAVITY OF COVID-19 IN INDIVIDUALS CO-INFECTED WITH THE HUMAN IMMUNODEFICIENCY VIRUS (HIV)
Isla Naraelly Gonçalves de Moura Rosendo1*, José Luiz de Campos Ribeiro Júnior1, Myllena Carolina Sales da Silva1, Nayhara Rayanna Gomes da Silva1, Thais Monteiro de Lucena1, Aracele Tenório de Almeida e Cavalcanti2.
1Student in Universidade Federal de Pernambuco (UFPE), 2Professor in UFPE.
Objective: To identify the levels of severity of COVID-19 in individuals co-infected with the Human Immunodeficiency Virus (HIV).
Methods: Expanded summary of the literature review type. The searches were carried out in the main databases of the BVS and CAPES. The above authors declare that they do not have conflict of interest in this study.
Results: Most individuals were being treated with antiretrovirals (83-100%) and, therefore, most had a TCD4 lymphocyte count above 200 cells/µL and a viral load ranging between 67-100%. Comorbidities ranged from 33-70% and deaths from 0-14%. The severity picture was mostly mild, at a minimum proportion of 63%, not significantly differing from the population with COVID-19 in general, which on average remains in a mild symptomatic picture, around 80%. Therefore, the percentage of deaths and more severe levels of the disease were lower than expected due to the immune deficiency of HIV positive people.
Conclusion: It is rash to make generalizations about the topic or to safely close the hypothesis that the immunosuppression of individuals with HIV, co-infected with SARS-CoV-2 has an increased risk to acquire the most severe form of COVID-19. This is because the studies found in the literature did not have a sample of participants significant enough.
Keywords: Coronavirus infections. Coinfection. HIV. Immunosuppression.
How to cite this article:
Isla Naraelly Gonçalves de Moura Rosendo, José Luiz de Campos Ribeiro Júnior, Myllena Carolina Sales da Silva, Nayhara Rayanna Gomes da Silva, Thais Monteiro de Lucena, Aracele Tenório de Almeida e Cavalcanti. IMPACTS OF IMMUNOSUPPRESSION ON THE GRAVITY OF COVID-19 IN INDIVIDUALS CO-INFECTED WITH THE HUMAN IMMUNODEFICIENCY VIRUS (HIV). American Journal of Microbiology and Immunology, 2021, 6:9. DOI: 10.28933/ajmi-2021-06-1806
1. Byrd KM, Beckwith CG, Garland JM, Johnson JE, Aung S, Cu-Uvin S, et al. SARS-CoV-2 and HIV coinfection: clinical experience from Rhode Island, United States. J Int AIDS Soc. 2020 june 19; 23: e25573. doi: https://doi.org/10.1002/jia2.25573
2. Vizcarra P, Elías MJP, Quereda C, Moreno A, Vivancos MJ, Dronda F, et al. Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort. Lancet HIV. 2020 may 28; 7: e554–64. doi: https://doi.org/10.1016/S2352-3018(20)30164-8
3. Ministério da Saúde (Brasil). Orientações para manejo de pacientes com COVID-19. Brasília: Ministério da Saúde; 18 jun 2020. [citado em 2020 set. 18]. Disponível em: https://portalarquivos.saude.gov.br/images/pdf/2020/June/18/Covid19-Orientac–o–esManejoPacientes.pdf
4. Ministério da Saúde (Brasil), Nota informativa Nº 17/2020-SE/GAB/SE/MS. Orientações do Ministério da Saúde para manuseio medicamentoso precoce de pacientes com diagnóstico da COVID-19. Brasília: Ministério da Saúde; 12 maio 2020. [citado em 2020 set. 18]. Disponível em: https://saude.gov.br/images/pdf/2020/August/12/COVID-11ago2020-17h16.pdf
5. Accinelli RA, Zhang-Xu CM, Ju-Wang JD, Yachachin-Chávez JM, Cáceres-Pizarro JA, Tafur-Bances KB, et al. COVID-19: la pandemia por el nuevo virus SARS-CoV-2. Rev Peru Med Exp Salud Publica. 2020;37(2): p302-11. doi: https://doi. org/10.17843/rpmesp.2020.372.5411
6. Mirzaei H, McFarland W, Karamouzian M, Sharifi H. COVI-19 among people living with HIV: A systematic review. AIDS Behav. 2020 july 30. doi: https://doi.org/10.1007/s10461-020-02983-2
7. Molina-Iturritza E, San-José-Muñiz I, Ganchegui-Aguirre M, Balerdi-Sarasola L, Ortiz-de-Zárate-Ibarra Z, Gainzarain-Arana JC, et al. Coronavirus disease 2019 in patients with HIV in the province of Araba, Basque Country, Spain. AIDS. 2020 September 1;34(11): e1696-97. doi: 10.1097/QAD.0000000000002608
8. Stoeckle K, Johnston CD, Jannat-Khah DP, Williams SC, Ellman TM, Vogler MA, et al. COVID-19 in hospitalized adults with HIV. OFID. 2020 august 01; 7(8). doi: https://doi.org/10.1093/ofid/ofaa327
9. Guo W, Ming F, Feng Y, Zhang Q, Mo P, Liu L, et al. Patterns of HIV and SARS-CoV-2 co-infection in Wuhan, China. J Int AIDS Soc. 2020 june 15; 23: e25568. doi: https://doi.org/10.1002/jia2.25568
10. Marimuthu J, Kumar BS, Aravind GP. HIV and SARS CoV-2 co-infection: A retrospective, record based, case series from South India. J Med Virol. 2020 july 07. doi:https://doi.org/10.1002/jmv.26271
11. Hu Y, Ma J, Huang H, Vermund SH. Coinfection with HIV and SARS-CoV-2 in Wuhan, China: A 12-person case series. J Acquir Immune Defic Syndr. 2020 Jun 12; 85(1): p1-5. doi: 0.1097/QAI.0000000000002424
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