To Estimate the level of Oxidative stress parameter among Diabetic persons with Squamous cell carcinoma of oral cavity: A Case Control Study

To Estimate the level of Oxidative stress parameter among Diabetic persons with Squamous cell carcinoma of oral cavity: A Case Control Study

Shashidhar K.N, Harshith Gowda KB, Munilakshmi. U, Hemalatha. A, Vinay Babu. S

Sri Devaraj Urs Medical College, Kolar, Karnataka, India

American Journal of Cancer Research and Reviews

Background: Diabetes mellitus and cancer share common modifiable and non- modifiable risk factors. Both conditions have a great impact on social and economic status of an individual and their families. Diabetes is rapidly becoming a common metabolic problem in rural populations. At the same time, the incidence of oral cancer has not decreased over the years despite exhaustive research and has become the most common cause of death. Oral cancer accounts for approximately 4-5% of all cancers in the world. Recent epidemiological studies have shown a strong link between diabetes and cancer. Objective: To Estimate the concentration of Oxidative stress markers among Diabetic persons with Squamous cell carcinoma of oral cavity .Materials and Methods: A Case Control study, conducted at Sri Devaraj Urs Medical College attached to Sri R.L. Jalappa Hospital a constituent of Sri Devaraj Urs Academy of Higher Education and Research, Kolar. A total of 60 subjects were included in the study and categorised into equal number of cases and controls. Diabetic and lipid profiles were estimated by enzymatic methods in Dry chemistry Autoanalyser, Vitros 5.1FS, HbA1c analysed by HPLC (BioRad D10 USA), Nitric Oxide, Malondialdehyde, and Vitamin C by spectrophotometer Perkin Elmer UV/ VIS Lambda-35 methods respectively. Results: Our patients were in the age group of 30- 80 years with a mean age of 52.62± 12.67. Diabetic profile and oxidant markers were significantly elevated in cases compared to controls. However, mean values of lipid profile and antioxidants were significantly reduced in cases with an exception of LDL cholesterol, when comparing with controls Conclusion: Observations that has been made with lipid profile and antioxidant variables in diabetes with SCC was reduced might be due to their increased utilization by neoplastic cells for new membrane biogenesis.
These findings strongly suggest, evaluation of these variables may help better patient care and build nation as well in addition to health education.

Keywords:Diabetes Mellitus, Lipid Profile, Oral Cancer, Squamous cell Carcinoma

Free Full-text PDF

How to cite this article:
Shashidhar K.N, Harshith Gowda KB, Munilakshmi. U, Hemalatha. A, Vinay Babu. S. To Estimate the level of Oxidative stress parameter among Diabetic persons with Squamous cell carcinoma of oral cavity: A Case Control Study. American Journal of Cancer Research and Reviews, 2018,2:7. DOI: 10.28933/ajocrr-2018-06-2801

1. WHO report. Cancer Report. 2014.
2. Anil K C, William F A, Joannie, Lortet T, Mariapaula C. Worldwide trends in incidence of oral cavity and oropharyngeal cancer, Journal of clinical oncology.2013;31(36): 4550-4559.
3. Malawall AM, Silverman S, Mani NJ. Oral cancer in 57,518 IW of Gujarat, India. Cancer, 1976; 37: 1882-1886.
4. Kalyani R, Das S, Bindra Singh MS, Kumar H. Cancer profile in Kolar. Indian J Cancer 2010; 47:160-165.
5. Jerjes W, Upile T, Petrie A, Riskalla A, Hamdoon Z, Vourvachis M. Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients. Head Neck Oncol 2010; 2-9.
6. Maskari AY, Maskari MY, Sudairy S. Oral manifestations and complications of diabetes mellitus. A review. Sultan Qaboos Univ Med J 2011; 11:179-186.
7. Lin Y, Sun Z. Current views on type 2 diabetes. J Endocrinol 2010;204:1-11.
8. Edward G, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA. Diabetes and cancer: A consensus report. Diabetes care 2010; 33(7):1674-1685.
9. Travier N, Jeffereys M, Brewer N, Wright CS, Cunningham CW, Hornell J. Association between glycosylated hemoglobin and cancer risk: A New Zealand Linkage Study. Ann Oncol 2007; 18(8): 1414-1419.
10. Burlakova EB, Zhizhins GP, Gurevier SM, Lyudmila D. Biomarkers of Oxidative stress and smoking in cancer patients J Cancer Res Ther 2010; 6: 47-53
11. Kamath A, Shashidhar KN, Anantharamaiah H, Rangareddy H, Sathyanarayana. Risk factors, lipid profile, and histopathological study of oral cancers in Kolar district: a case-control studyJ Cancer Res Ther 2014; 10(1):171-5.
12. Patel PS, Shah MH, Jha FP, Raval GN, Rawal RM, Patel MM, et al. Alterations in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions. Indian J Cancer. 2004;41:25–31.
13. Gurudath S, Ganapathy K, Pai A, Ballal S. Estimation of superoxide dismutase and glutathione peroxidase in oral submucous fibrosis, oral leukoplakia and oral cancer-a comparative study. Asian pac Jcancer Prev. 2012;13:4409-4412
14. Dikshit RP, Ramadas K, Hashibe M, Thomas G, Somanathan T, Sankaranarayanan R. Association between diabetes mellitus and pre- malignanat oral diseases: A J Cancer 2006;118:453-457.
15. Ujpal M, Matos O, Bibok G, Somogyi A. Diabetes and oral tumors in Hungary: epidemiological correlations. Diabetes Care 2004; 27(3): 770-774.
16. Sen MP, Nandita S, Ashok S, Prabha A. Diabetes mellitus and oral cancer: Are they connected? Indian Journal of oral health and research 2015;1(1):4-6.
17. Seppala B, Sorsa T, Ainamo J. Morphometric analysis of cellular and vascular changes in gingival connective tissue in long term insulin dependent diabetes J Peridontol 2010;68:1237-1245.
18. Vairaktaris E, Spyridonidou S, Goutzanis L, Vylliotis A, Lazaris A, Donta I et al. Diabetes and oral oncogenesis. Anticancer Res 2007; 27(6B):4185-4193.
19. Lohe VK, Degwekar SS, Bhowate RR, Kadu RP, Dangore SB. Evaluation of correlation of serum lipid profile in patients with oral cancer and precancer and its association with tobacco abuse. J Oral Pathol Med. 2010; 39:141–148.
20. Alexopoulous CG, Blatsios B, Avgerinos A. Serum lipids and lipoprotein disorders in cancer patients. Cancer 2013; 60: 3065-3070.
21. Chawda JG, Jain SS, Patel HR, Chaduvula N, Patel K. The relationship between serum lipid levels and the risk of oral cancer. Indian J Med Paediatr Oncol. 2011; 32: 32–35.
22. Chavez J, Silverman JR. Demographics and occurrence of oral and pharyngeal cancers: The outcomes, the trends, the challenge. Journal of Ammerical dental association 2014; 132: 7-11.
23. Mulholland CW, Elwood C, Davis A, Thurnham DI. Antioxidant enzymes, inflammatory indices and lifestyle factors in older men: A cohort analysis. QMJ 2012; 92:579-585.

Terms of Use/Privacy Policy/ Disclaimer/ Other Policies:
You agree that by using our site, you have read, understood, and agreed to be bound by all of our terms of use/privacy policy/ disclaimer/ other policies (click here for details)

CC BY 4.0
This work and its PDF file(s) are licensed under a Creative Commons Attribution 4.0 International License.