Clinical and Histopathological Evaluation of Prurigo Nodularis

Clinical and Histopathological Evaluation of Prurigo Nodularis

1Khalifa E. Sharquie MD, PhD, FRCP Edin, 2Safa Ibrahim MD

1Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology & Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq.
2Center of Dermatology, Medical City Teaching Hospital.

Background: Prurigo nodularis (PN) is a well-defined chronic recognized entity as a cause of severe chronic itching. However, this medical problem is not well studied and evaluated previously in Iraqi population.

Objective: To do full clinical and histopatholgical evaluation of patient with PN.

Patients and methods: This study is an observational cross sectional that was conducted at the Center of Dermatology, Medical City Teaching Hospital. All cases with classical PN and localized variant where collected. Full clinical evaluation was carried out. Biopsies were taken from 10 patients out of 50 with prurigo nodularis processed and stained with Hematoxylin and Eosin.

Results: Fifty patients were included, there were 22 (44%) males and 28 (56%) females ,their  ages ranged  from  less than 20-60 years with mean ± SD of  age (40 ± 16) years .The common associated disease was atopic dermatitis in 36 (72%)  patients, while family history of disease was seen in 24 (48%) patients, psychological factor  was seen in 30 (60%) patients . The clinical picture was excoriated nodular lesions commonly on limbs with symmetrical fashion in 40 (80%) of cases while localized pattern was detected in 10 (20%) of patients. Histopatholgical evaluation in ten patients had shown hyperkeratosis (100%), acanthosis (60%), and pseudoepithelamatous hyperplasia (40%). Eosinophils were seen in one patient.

Conclusion: This study showed classical prurigo nodularis in 80% of cases while localized in 20% of the patients. It is a disease of middle age patients, more in females than males. Family and personal history of atopic dermatitis was a high finding the histopathology is typical of prurigo nodularis with sparse eosinophils.

Keywords:Prurigo nodularis; Histopathology; Hematoxylin and Eosin stain.

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How to cite this article:
Khalifa E. Sharquie, Safa Ibrahim.Clinical and Histopathological Evaluation of Prurigo Nodularis. American Journal of Dermatological Research and Reviews, 2020, 3:27. DOI: 10.28933/ajodrr-2020-05-1105


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