Research Article of American Journal of Dermatological Research and Reviews
Treatment of Recurrent Aphthous Stomatitis by Crude Topical Sesame Seed Oil in Comparison with Crude Topical Pumpkin Seed Oil
1Professor Adil A. Noaimi MD, DDV, FICMS., 2Douaa S. Ahmed MD.
1Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. 2Center of Dermatology; Baghdad Teaching Hospital; Medical City, Baghdad, Iraq.
Background: Recurrent aphthous stomatitis (RAS) is the most common disease of the oral mucosa in the general population. Multifactorial etiopathogenesis has been suggested to explain the cause of RAS but the exact etiology and pathogenesis still unknown. Its therapy whether topical or systemic can induce clearance but the relapse rate is high.
Objective: To evaluate the efficacy and prophylactic effects of topical Sesame seed oil in comparison with Pumpkin seed oil in the management of recurrent aphthous stomatitis.
Patients and Methods: This is a single, blinded, clinical, therapeutic, comparative study where 35 patients with early onset RAS were examined in Center of Dermatology -Baghdad Teaching Hospital, Medical City ,Baghdad, Iraq from April 2018-October 2019. All socio-demographic data related to the disease was obtained from each patient, in addition to clinical examination was performed for each patient. Patients were divided into 2 groups: Group A (15 patients) used crude Sesame seed oil twice daily. Group B (20 patients) was instructed to use Pumpkin seed oil in a similar way to Group A. Short term assessment of each patient of both groups was done to evaluate the therapeutic effect of drug by using oral clinical manifestation index (OCMI). A long term assessment was done for each patient to assess the prophylactic effect of drug by using OCMI before, after 1, 2 and 3 months of therapy. They were seen regularly to record any local or systemic side effects.
Results: The patients enrolled in this study were 19 (54.3%) males and 16(45.7%) females, male to female ratio was 1.1: 1. Their ages ranged from 12-60 (35.33 ± 12.06) years. The mean of OCMI in Group A started to decline directly after 4 days of therapy and went to its lower level after 8 days of therapy, and it was statistically significant (P value <0.05). The change in the mean of OCMI of Group B after 8 days of therapy was also statistically significant (P value <0.05). The difference in the response rates after 8 days between Group A and B was statistically significant (P value <0.05). Both groups showed statistically significant prophylactic effect after 1, 2 and 3 months from starting therapy, but sesame seed oil was statistically more significant than pumpkin oil effect during 2nd & 3rd months of therapy. No significant side effects were noticed in both groups as both oils are edible foods.
Conclusion: Sesame and pumpkin seed oil have an effective therapeutic and prophylactic action against RAS. No local or systemic side effects were observed during the course of therapy.
Keywords: Sesame seed oil, Pumpkin seed oil, recurrent aphthous stomatitis.
How to cite this article:
Adil A. Noaimi, Douaa S. Ahmed.Treatment of Recurrent Aphthous Stomatitis by Crude Topical Sesame Seed Oil in Comparison with Crude Topical Pumpkin Seed Oil.American Journal of Dermatological Research and Reviews, 2020, 3:30. DOI: 10.28933/ajodrr-2020-06-2405
1. Jurge S, Kuffer R, Scully C, Porter SR. Number VI recurrent aphthous stomatitis. Oral diseases. 2006 Jan; 12(1):1-21.
2. Riera Matute G, Riera Alonso E. Recurrent aphthous stomatitis in Rheumatology. Reumatol Clin. 2011; 7(5):323-8.
3. Andrews’s diseases of the skin, Clinical dermatology. Belenguer I,Chaven M, Scully C. Philadelphia. WB Saunders Company. 12th ed.2016; 34: 803-12.
4. Compilato DO, Carroccio AN, Calvino FR, Di Fede G, Campisi G. Hematological deficiencies in patients with recurrent aphthosis. Journal of the European Academy of Dermatology and Ve-nereology. 2010 Jun; 24(6):667-73.
5. Baccaglini L, Lalla RV, Bruce AJ, Sartori-Valinotti JC, Latortue MC, Carrozzo M. Urban legends: re-current aphthous stomatitis. Oral Dis. 2011; 17:755–70.
6. Sharquie KE, Najim RA. Honey as a new skin tissue preservative. J. Pan-Arab League Derma-tol. 2001; 12: 49-54.
7. Sharquie KE, Al-Tammimy SM, Al-Mashhadani S, Hayani RK, Al-Nuaimy AA. Lactic acid 5 percent mouthwash is an effective mode of therapy in treatment of recurrent aphthous ulcerations. Dermatology online journal. 2006; 12(7).
8. Sharquie KE, Al Mashhadani SA, Noaimi AA, Al-Hayani RK, Shubber SA. Lactic Acid 5% Mouthwash is an Effective Therapeutic and Prophylactic Agent in Treatment of Recurrent Aphthous Ul-cer (Single blind placebo controlled therapeutic study. Iraqi Academic Scientific Journal. 2012; 11(3):363-9.
9. Sharquie KE, Hayani RK. BCG as a new thera-peutic and prophylactic agent in patients with severe oral aphthosis. Clinical and experimental rheumatology. 2005; 23(6):914.
10. Sharquie KE, Al-Mashhaddani, Al-Nuaimy AA, Shubber SA.The Therapeutic and Prophylactic Efficacy of 5% lactic acid, 5% zinc sulphate mouthwash and Topical 100% Nigella Sativa Oil in Management of Recurrent Aphthous Ul-cers.Thesis submitted to The Iraqi Board for Medical Specialization, 2006.
11. Sharquie KE, Najim RA, Al-Hayani RK, Al-Nuaimy AA, Maroof DM. The therapeutic and prophylactic role of oral zinc sulfate in management of recurrent aphthous stomatitis (RAS) in comparison with dapsone. Saudi Medical Journal. 2008 May 1; 29(5):734.
12. Altenburg A, Zouboulis CC. Current concepts in the treatment of recurrent aphthous stomatitis. Skin Therapy Lett. 2008; 13(7):1–4.
13. Sharquie KE, Helmi RM, Noaimi AA, Kadhom MA, Al-Hayani RK. Therapeutic Role of Isotretinoin in the Management of Recurrent Aphthous Stomatitis (Single-Blind Controlled Therapeutic Study). Journal of Cosmetics, Dermatological Sciences and Applications. 2015 Feb 4; 5(01):15.
14. Aphthous Stomatitis. Mirowski G W and Nebesio C L. http://www.emedicine.com. Sep. 2004.
15. De Abreu MA, Hirata CH, Pimentel DR, Weckx LL. Treatment of recurrent aphthous stomatitis with clofazimine. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 108:714–21.
16. Sharquie KE, Noaimi AA, Latif T. Treatment of Recurrent Aphthous Stomatitis by 100% Topical Pumpkin Seed Oil. Journal of Cosmetics, Dermatological Sciences and Applications. 2017 Nov 9; 7(04):324.
17. Kumar CM, Singh SA. Bioactive lignans from sesame (Sesamum indicum L.): evaluation of their antioxidant and antibacterial effects for food applications. Journal of food science and technology. 2015 May 1; 52(5):2934-41.
18. Saydut A, Duz MZ, Kaya C, Kafadar AB, Hamamci C. Transesterified sesame (Sesamum indicum L.) seed oil as a biodiesel fuel. Bioresource Technology. 2008 Sep 1; 99(14):6656-60.
19. Hsu DZ, Chu PY, Liu MY. Sesame seed (Sesamum indicum L.) extracts and their anti-inflammatory effect. In Emerging Trends in Dietary Components for Preventing and Combating Disease. American Chemical Society; 2012 (335-341).
20. Monteiro É, Chibli L, Yamamoto C, Pereira M, Vilela F, Rodarte M, de Oliveira Pinto M, da Penha Henriques do Amaral M, Silvério M, de Matos Araújo A, da Luz André de Araújo A. An-tinociceptive and anti-inflammatory activities of the sesame oil and sesamin. Nutrients. 2014; 6(5):1931-44.
21. Nagendra Prasad MN, Sanjay KR, Prasad DS, Vijay N, Kothari R, Nanjunda Swamy S. A review on nutritional and nutraceutical properties of sesame. J Nutr Food Sci . 2012; 2(127):2.