Treatment of Recurrent Aphthous Stomatitis by Crude Topical Sesame Seed Oil in Comparison with Crude Topical Pumpkin Seed Oil


Treatment of Recurrent Aphthous Stomatitis by Crude Topical Sesame Seed Oil in Comparison with Crude Topical Pumpkin Seed Oil


1Professor Adil A. Noaimi MD, DDV, FICMS., 2Douaa S. Ahmed MD.

1Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. 2Center of Dermatology; Baghdad Teaching Hospital; Medical City, Baghdad, Iraq.


Background: Recurrent aphthous stomatitis (RAS) is the most common disease of the oral mucosa in the general population. Multifactorial etiopathogenesis has been suggested to explain the cause of RAS but the exact etiology and pathogenesis still unknown. Its therapy whether topical or systemic can induce clearance but the relapse rate is high.

Objective: To evaluate the efficacy and prophylactic effects of topical Sesame seed oil in comparison with Pumpkin seed oil in the management of recurrent aphthous stomatitis.

Patients and Methods: This is a single, blinded, clinical, therapeutic, comparative study where 35 patients with early onset RAS were examined in Center of Dermatology -Baghdad Teaching Hospital, Medical City ,Baghdad, Iraq from April 2018-October 2019. All socio-demographic data related to the disease was obtained from each patient, in addition to clinical examination was performed for each patient. Patients were divided into 2 groups: Group A (15 patients) used crude Sesame seed oil twice daily. Group B (20 patients) was instructed to use Pumpkin seed oil in a similar way to Group A. Short term assessment of each patient of  both groups was done to evaluate the therapeutic effect of drug by using oral clinical manifestation index (OCMI). A long term assessment was done for each patient to assess the prophylactic effect of drug by using OCMI before, after 1, 2 and 3 months of therapy. They were seen regularly to record any local or systemic side effects.

Results: The patients enrolled in this study were 19 (54.3%) males and 16(45.7%) females, male to female ratio was 1.1: 1. Their ages ranged from 12-60 (35.33 ± 12.06) years.  The mean of OCMI in Group A started to decline directly after 4 days of therapy and went to its lower level after 8 days of therapy, and it was statistically significant (P value <0.05). The change in the mean of OCMI of Group B after 8 days of therapy was also statistically significant (P value <0.05).  The difference in the response rates after 8 days between Group A and B was statistically significant (P value <0.05). Both groups showed statistically significant prophylactic effect after 1, 2 and 3 months from starting therapy, but sesame seed oil was statistically more significant than pumpkin oil effect during 2nd & 3rd months of therapy. No significant side effects were noticed in both groups as both oils are edible foods.

Conclusion: Sesame and pumpkin seed oil have an effective therapeutic and prophylactic action against RAS. No local or systemic side effects were observed during the course of therapy.


Keywords: Sesame seed oil, Pumpkin seed oil, recurrent aphthous stomatitis.

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How to cite this article:
Adil A. Noaimi, Douaa S. Ahmed.Treatment of Recurrent Aphthous Stomatitis by Crude Topical Sesame Seed Oil in Comparison with Crude Topical Pumpkin Seed Oil.American Journal of Dermatological Research and Reviews, 2020, 3:30. DOI: 10.28933/ajodrr-2020-06-2405


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