Research Article of American Journal of Dermatological Research and Reviews
Assessment of efficacy and tolerability of fractional CO2 laser in the treatment of axillary hyperpigmentation
Nevine A. Dorgham, Dina A. Dorgham
Dermatology Department, Kasr Al Ainy Hospital, Cairo University,Egypt
Background: Axillary hyperpigmentation is a common and troublesome complaint especially among dark-skinned women. It is believed to be a form of post-inflammatory hyperpigmentation and so far, there is no universally accepted treatment for the disorder.
Objective: The aim of this study is to assess the efficacy of fractional CO2 laser in the treatment of axillary hyperpigmentation
Patients and methods: Thirty Egyptian females with axillary hyperpigmentation were recruited. The severity of the condition was estimated by both self-assessment and expert dermatologist before treatment. Four sessions of fractional CO2 laser were done. Both the efficacy and complications were assessed by the patient and the dermatologist six month after the last session.
Results: There was a statistically significant difference of percentage of improvement of pigmentation before compared to one month after treatment as detected by self-assessment (p value= 0.002) and the observer’s assessment (p value= 0.001).
Conclusion: Fractional CO2 laser, in properly chosen parameters, is an effective method for the treatment of axillary hyperpigmentation.
Keywords: Axillary hyperpigmentation, fractional CO2 laser
How to cite this article:
Nevine A. Dorgham, Dina A. Dorgham. Assessment of efficacy and tolerability of fractional CO2 laser in the treatment of axillary hyperpigmentation. American Journal of Dermatological Research and Reviews, 2021, 4:38. DOI: 10.28933/ajodrr-2020-12-0105
1. James AG, Pople JE, Parish W, Moore AE, Dunbar N. Histological evaluation of hyperpigmentation on female Filipino axillary skin International Journal of Cosmetic Science, 2006, 28, 247–253
2. Alexis AF, Sergay AB, Taylor SC. Common dermatologic disorders in skin of color: a comparative practice survey. Cutis. 2007;80: 387–394.
3. Lamel SA, Rahvar M, Maibach HI. Postinflammatory hyperpigmentation secondary to external insult: an overview of the quantitative analysis of pigmentation. Cutan Ocul Toxicol. 2012;32:67–71.
4. James AG, PhD, Unilever Colworth, Sharnbrook, Bedfordshire, United Kingdom; Vernon Marti, PhD, Unilever R&D Port Sunlight, Bebington, Wirral, United Kingdom; Jennifer Pople, PhD, Unilever R&D Colworth, Sharnbrook, Bedfordshire, United Kingdom; Sarah Paterson, MS, Unilever R&D Port Sunlight, A sunflower seed oil-containing antiperspirant for controlling axillary darkening in Latin American women. J Am Acad Dermatol 2017; p 2614,Feb.
5. Ahn HH, Kim IH. Whitening effect of salicylic acid peels in Asian patients. Dermatol Surg. 2006; 32:372–375.
6. Polder KD, Landau JM, Vergilis-Kalner IJ, Goldberg LH, Friedman PM, Bruce S. Laser eradication of pigmented lesions: a review. Dermatol Surg. 2011; 37:572–595.
7. Sarkar R, Arora P, Garg VK, et al. Melasma update. Indian Dermatol Online J. 2014 Oct;5(4):426-35.
8. Sofen B, Prado G, BS, Emer J, Melasma and Post Inflammatory Hyperpigmentation: Management Update and Expert Opinion. Skin therapy letter (21)1: 2016
9. Hsiao CY, Huang CH, Hu S, Ko YS, Sung HC, Chen CC, Huang SY: Fractional carbon dioxide laser treatment to enhance skin permeation of ascorbic acid 2-glucoside with minimal skin disruption. Dermatol Surg 2012; 38:1284–1293.
10. Lee WR, Shen SC, Pai MH, Yang HH, Yuan CY, Fang JY: Fractional laser as a tool to enhance the skin permeation of 5-aminolevulinic acid with minimal skin disruption: acomparison with conventional erbium:YAG laser. J Control Release 2010; 145: 124–133.
11. Hantash BM, Bedi VP, Sudireddy V et al. Laser-induced transepidermal elimination of dermal content by fractional photothermolysis. J Biomed Opt2006; 11: 041115
12. Chan YH (2003): Biostatistics102: Quantitative Data – Parametric & Non-parametric Tests. Singapore Med J.;44(8): 391-396.
13. Watkinson, A., Lee, R.S., Moore, A.E. et al. Reduced barrier efficiency in axillary stratum corneum. Int. J. Cosmet. Sci. 24, 151–161 (2002).
14. Turner, G.A., Moore, A.E., Marti, V.P.J. et al. Impact of shaving and anti-perspirant use on the axillary vault. Int. J. Cosmet. Sci. 29, 31–38 (2007).
15. Marti, V.P.J., Lee, R.S., Moore, A.E. et al. Effect of shaving on axillary stratum corneum. Int. J. Cosmet. Sci. 25, 193–198 (2003).
16. Summey, B.T. and Yosipovitch, G. Itch associated with dryness of the skin: the pathophysiology and influence of moisturizers. In: Dry Skin and Moisturizers: Chemistry and Function (Loden, M. and Maibach, H.I., eds), pp. 127–133. CRC Taylor and Francis Group, Boca Raton, FL, USA (2006).
17. Patel AB. Post inflammatory hyperpigmentaion: Review of pathogenesis, prevention, and treatment. 2014. Pigment International 1(2) 59-69
18. Vachiramon V, Panmanee W, Techapichetvanich T, Chanprapaph K. Comparison of Q-switched Nd: YAG laser and fractional carbon dioxide laser for the treatment of solar lentigines in Asians. Lasers Surg Med. 2016 Apr;48(4):354-9.
19. Tannous ZS & Astner S. Utilizing fractional resurfacing in the treatment of therapy-resistant melasma. Journal of Cosmetic and Laser Therapy. 2005; 7: 39–43
20. Hsiao CY, Sung HC, Hu S, Huang YL and Huang CH. Fractional CO2 Laser Pretreatment Facilitates Transdermal Delivery of Two Vitamin C Derivatives. Molecules 2016, 21, 1547
21. Manstein D, Herron GS, Sink RK, Tanner H, Anderson RR. Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med. 2004;34(5):426–38.
22. Chan HH. Effective and safe use of lasers, light sources, and radiofrequency devices in the clinical management of Asian patients with selected dermatoses. Lasers Surg Med 2005; 37:179-85
This work and its PDF file(s) are licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.