Research Article of American Journal of Dermatological Research and Reviews
Infantile acne is a medical problem that calls for therapy
1Khalifa E Sharquie, MD,PhD,FRCP Edin; 2Hamed A Al Farhan, MD,DD; 3Wisam S Najim, MD,FICM; 4Raed I Jabbar, MD ,CABD.
1Department of Dermatology, College of Medicine, University of Baghdad, Medical City Teaching Hospital,Baghdad ,Iraq. 2,3Deprtment of Dermatology, College of Medicine ,Tikrit University, Iraq. 4Department of Dermatology ,Fallujah Teaching Hospital ,Al-Anbar Health Directorate , Anbar , Iraq.
Background: Acne vulgaris of infants is a well-recognized medical and cosmetic problem as it may cause severe scarring of the face. Hence medical treatment is essentially needed.
Objective: To record all patients with infantile acne vulgaris and to do full demographic and clinical evaluation.
Patients and methods:This is case series clinical descriptive study with interventional therapeutic trial that included all patients with infantile acne vulgaris that were seen during the period from Jan 2021 – September 2021 years. All demographic and clinical features were recorded. The clinical scoring of acne severity was done as follow:mild when the rash was mainly comedones,moderate mainly papules and pustules and severe mainly nodules and scarring. Any triggering factors were recorded including hormonal changes. Therapy was started by giving topical 2% clindamycin twice a day and oral trimethoprim-sulfamethoxazole suspension one teaspoonful twice a day for 1-2 months.
Results: This study included 28 patients with infantile acne, with 19(67.86%) males and 9(32.14%) females with male to female ratio;2.1. The age of patients ranged from 1-24 months, with a mean 14.6 ±6.1.The duration of rash was ranged from 4-8 weeks. The commonest sites affected were cheeks in 27(96.4%) cases, followed by forehead in 8 (28.6%), then chin in 6 (23.1%), and nose 6 (23.1%) of the cases. Scoring of severity of acne showed moderate in 13(46.4%), followed by mild in 9 (32.1%), and sever in 6 (21.4%). The response to treatment was complete clearance in 15(53.6%) and partial response in 13(46.4%) of the patients while no adverse effects were observed.
Conclusions: Infantile acne is not uncommon disease among infants where medical therapy is essentially needed especially in severe cases as to prevent facial scarring. Early diagnosis and treatment with oral trimethoprim-sulfamethoxazole suspension and topical 2% clindamycin lotion is an effective mode of therapy.
Keywords: Infantile acne, therapeutic trial ,clindamycin ,trimethoprim-sulfamethoxazole
How to cite this article:
Khalifa E Sharquie, Hamed A Al Farhan, Wisam S Najim, Raed I Jabbar. Infantile acne is a medical problem that calls for therapy. .American Journal of Dermatological Research and Reviews, 2022, 5:49. DOI: 10.28933/ajodrr-2021-10-1805
1. Serna-Tamayo C, Janniger CK, Micali G, Schwartz RA. Neonatal and infantile acne vulgaris: an update. Cutis. 2014; 94(1):13-6.
2. Eichenfield LF, Krakowski AC, Piggot C, et al. Evidence based recommendations for the diagnosis and treatment of paediatric acne. Paediatrics. 2013;131:S163–86.
3. Paller AS, Mancini AJ. Paller and Mancini-Hurwitz Clinical Pediatric Dermatology E-Book: A Textbook of Skin Disorders of Childhood and Adolescence,6th ed. Elsevier Health Sciences, 2020 ; 8:180-185.
4. Kang SK, Jee MS, Choi JH, et al. A case of infantile acne due to Pityrosporum. Pediatr Dermatol. 2003;20:68-70.
5. Mathes E, Howard R, Edwards MS. Vesicular, pustular, and bullous lesions in the newborn and infant. UpToDate. Available. 2018.
6. Dessinioti C, Zouboulis CC, Bettoli V, Rigopoulos D. Comparison of guidelines and consensus articles on the management of patients with acne with oral isotretinoin. J Eur Acad Dermatol Venereol. 2020 ;34(10):2229-40.
7. Filo-Rogulska M, Wcislo-Dziadecka D, Brzezinska-Wcislo L. Neonatal and infantile acne-etiopathogenesis, clinical presentation and treatment possibilities. Post N Med. 2018;31(1A):45-8.
8. Antoniou C, Dessinioti C, Stratigos AJ, et al. Clinical and therapeutic approach to childhood acne: an update. Pediatr Dermatol. 2015; 26:373-380.
9. Lu LY, Lai HY, Pan ZY, Wu ZX, Chen WC, Ju Q. Obese/overweight and the risk of acne vulgaris in Chinese adolescents and young adults. Hong Kong J Dermatol Venereol. 2017 ;25(1):5-12.
10. Admani S, Barrio VR. Evaluation and treatment of acne from infancy to preadolescence. Dermatol Ther. 2013 ;26(6):462-6.
11. Bajaj DR, Devrajani BR, Shaikh S. Infantile Acne: A Clinical and Therapeutic Study of 12 Patients. World Applied Sciences Journal 2013 ; 20 (10): 1328-31.
12. Miller IM, Echeverría B, Torrelo A, Jemec GBE. Infantile Acne Treated with Oral Isotretinoin. Pediatr Dermatol.2013; 30: 513-518.
13. Cambazard F. Neonatal,infantile and puberty acne. Ann Dermatol Venereol.2003; 130: 107-12.
14. Stevanović DV.Acne in infancy. Australasian Journal of Dermatology.2007; 5(4): 224-9.
15. Filo-Rogulska1 M , Wcisło-Dziadecka D , Brzezińska-Wcisło L. Neonatal and infantile acne-ethiopathogenesis, clinical presentation and treatment possibilities. Post N Med 2018; XXXI (1A): 45-8.
16. Samycia M, Lam JM. Infantile acne. CMAJ. 2016;188 (17-18):E540.
17. Cunliffe WJ, Baron SE, Coulson IH. A clinical and therapeutic study of 29 patients with infantile acne. Br J Dermatol. 2001;145(3):463-6.
18. Šijak D, Horvat I, Sonicki Z, Murat-Sušić S, et al. Correlation between family history and the age of onset of childhood acne in relation to sex and type of acne. Acta dermatovenerologica Croatica. 2019 ;27(2):86-91.
19. Jansen T, Burgdorf WH, Plewig G. Pathogenesis and treatment of acne in childhood. Pediatr Dermatol. 1997 ;14(1):17-21.
20. Alakloby OM, Bukhari IA, Awary BH, Al-Wunais KM. Acne neonatorum in the eastern Saudi Arabia. Indian Journal of Dermatology, Venereology, and Leprology. 2008 ;74(3):298.
21. Serna-Tamayo C, Janniger CK, Micali G, Schwartz RA. Neonatal and infantile acne vulgaris: an update. Cutis. 2014;94(1):13-6.
22. Lucky AW. A review of infantile and pediatric acne. Dermatology. 1998;196(1):95-7.
23. Dogliotti . Acne Infantum in an Indian Child. oral S Air Med J. 1976; 50: 2106-7.
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