EFFECTIVENESS OF CONDROPROTECTORS IN TREATING OSTEOARTHRITIS: A BIBLIOGRAPHIC REVIEW

EFFECTIVENESS OF CONDROPROTECTORS IN TREATING OSTEOARTHRITIS: A BIBLIOGRAPHIC REVIEW

Alana Gomes de Souza¹*, Malu Avila Sobrinho de Vasconcelos², Nathalia Moura Fernandes², Cintia Justino Rabelo³, Bruno Souza dos Santos⁴, Marta Maria de França Fonteles¹

¹Universidade Federal do Ceará;²Centro Universitário Farias de Brito;³Centro Universitário Católica de Quixadá;⁴ Universidade Federal de Pernambuco;

Introduction: Osteoarthritis (OA) is the most common rheumatologic disease in the world and the elderly are the most affected, although there is no defined age for its onset. Obesity is a risk factor, with healthy eating habits and physical exercise practices being recommended for treatment and prevention. The pharmacological treatment for OA is oral chondroprotective agents and viscosupplements, although anti-inflammatory drugs are widely prescribed, they do not cause clinical improvement, they only treat the symptoms of the disease.

Objective: This study gathered articles from clinical trials in Brazil with the purpose of investigating whether the pharmacological treatments used are effective. Methods: The electronic platforms used for data collection were: Scielo, CAPES Journal Portal and Google Academic. Articles published in the last six years with clinical trials in Brazil were considered. Articles involving surgeries, those that used physiotherapy as an adjunct therapy and those that used animal or non-human research in their research were excluded. The search was through the descriptors: hyaluronic acid, glucosamine and chondroitin.

Results: The search resulted in six articles, in which three were used chondroprotectors and the other three viscosupplements. Chondroprotectors were effective in 66.66% of clinical trials and viscosupplements in 100%.

Conclusion: Pharmacological treatments for OA showed high efficacy, however the sample of the present work was small, thus, further studies are needed to confirm the results obtained.

Keywords: Osteoarthritis. Chondroprotectors. Viscosupplement

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How to cite this article:
Alana Gomes de Souza, Malu Avila Sobrinho de Vasconcelos, Nathalia Moura Fernandes, Cintia Justino Rabelo, Bruno Souza dos Santos, Marta Maria de França Fonteles.Effectiveness of Condroprotectors in Treating Osteoarthritis: a Bibliographic Review.American Journal of Orthopedic Research and Reviews, 2021, 4:25. DOI: 10.28933/ajorr-2021-08-1006

References:

1. ALVES, Janice Chaim; BASSITT, Debora Pastore. Qualidade de vida e capacidade funcional de idosas com osteoartrite de joelho. Einstein (São Paulo), 2013, 11.2: 209-215.
2. AMMAR, Tiago Youssef, et al. Viscossuplementacão no tratamento da osteoartrose do joelho: uma revisão da literatura. Revista Brasileira de Ortopedia, 2015, 50.5: 489-494.
3. BONOTTO, Daniel, et al. Viscosupplementation as a treatment of internal derangements of the temporomandibular joint: retrospective study. Revista Dor, 2014, 15.1: 2-5.
4. CAMPOS, Gustavo Constantino de. Chondroprotective agents: are we being too dogmatic?. MedicalExpress, 2014, 1.4: 211-213.
5. CARVALHO, Ravena Carolina de, et al. Prevalence and characteristics of chronic pain in Brazil: a national internet-based survey study. BrJP, 2018, 1.4: 331-338.
6. FERREIRA, Alyne Hevellen, et al. Investigação da ansiedade, depressão e qualidade de vida em pacientes portadores de osteoartrite no joelho: um estudo comparativo. Revista Brasileira de Reumatologia, 2015, 55.5: 434-438.
7. JOSÉ, Fábio Freire. Osteoartrite: fisiopatologia e tratamento medicamentoso. J. Bras. Med., 2013, 101.02: 47-52, 2013.
8. LAIRES, Pedro A., et al. Inadequate pain relief among patients with primary knee osteoarthritis. Revista brasileira de reumatologia, 2017, 57.3: 229-237.
9. LOPES JUNIOR, Osmar Valadao; INACIO, Andre Manoel. Uso de glucosamina e condroitina no tratamento da osteoartrose: uma revisão da literatura. Revista Brasileira de Ortopedia, 2013, 48.4: 300-306.
10. MARIANO, R.N. Comissão de Osteoartrite da sociedade Brasileira de Reumatologia. 2011. Available in <https://www.reumatologia.org.br/doencas-reumaticas/osteoartrite-artrose/> Access in Feb 21, 2019.
11. NAHAS, Ricardo Munir, et al. Viscossuplementação no tratamento de artrite pós-traumática de joelho durante 12 meses. Revista Brasileira de Medicina do Esporte, 2016, 22.6: 465-470.
12. REZENDE, Márcia Uchôa; DE CAMPOS, Gustavo Constantino; PAILO, Alexandre Felício. Conceitos atuais em osteoartrite. Acta Ortopédica Brasileira, 2013, 21.2: 120-122.
13. ROSIS, R. G.; MASSABKI, Paulo Sérgio; KAIRALLA, Maisa. Osteoartrite: avaliação clínica e epidemiológica de pacientes idosos em instituição de longa permanência. Rev Bras Clin Med, 2010, 8.2: 101-8.
14. SALVATO, Katia F., et al. Análise da influência da farmacoterapia sobre a qualidade de vida em idosos com osteoartrite. Revista Brasileira de Reumatologia, 2015, 55.1: 83-88.
15. SANTOS, João Paulo M., et al. Análise da funcionalidade de idosos com osteoartrite. Fisioterapia e Pesquisa, 2015, 22.2: 161-168.
16. SARTORI-CINTRA, Angélica Rossi; AIKAWA, Priscila; CINTRA, Dennys Esper Correa. Obesidade versus osteoartrite: muito além da sobrecarga mecânica. Einstein (São Paulo), 2014, 12.3: 374-379.
17. ZÓBOLI, Alejandro Agustin Carri, et al. Ensaio clínico prospectivo e randomizado: regime único e semanal de viscossuplementação. Acta Ortopédica Brasileira, 2013, 21.5: 271-275.