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The method for studying the adsorption characteristics of the coal seam has the density method, the mercury-pressing method and the adsorption method. In this experiment, a low temperature nitrogen adsorption method was used to determine the relative data of the coal-like porosity by using the surface area meter TriStarI3020 to determine the arrangement of the nitrogen molecules on the surface of the coal-like samples. Before the beginning of the experiment, the samples of Yang dong coal reservoir were prepared, weighed, the devaporation time was set at 2h, and the temperature was kept at 105℃.The low temperature nitrogen adsorption experiment was carried out by TriStarII3020.The data of adsorption of nitrogen molecules by coal samples at low temperature are obtained by experiments. The gap characteristics of coal samples are studied by analyzing the characteristic folding points and relative relations of the generated linear diagram. Get coal samples under the condition of low temperature changing with pressure adsorption nitrogen molecular data changes, through the analysis of the linear graph of generated features that are characteristic of fold point and relative relationship to study the space characteristics of the coal sample. Through the analysis can determine the area mainly for both ends of the open pores in coal mine, the porosity of the thin neck bottle type, this research has great significance to the adsorption of gas in the coal reservoir, facilitate monitoring during the coal mining operations have an impact on safety production of the gas such as gas. Can get the conclusion: in the low relative pressure p/p°< 0.1 the surface of the coal samples are distributed in nitrogen molecular monolayer, with the increase of pressure surface of coal samples began to multilayer adsorption intensified will appear the characteristics of the molecular cohesion, condensation of a pressure value after the single nitrogen...

This paper addresses the challenges in designing and provisioning digital services for public sector. The ongoing digitalization of public services calls for scalable models for ecosystem based collaborative service design. However, while digitalization of services has been studied extensively from technical and financial viewpoints, less focus has been devoted for the collaborative service design processes. In this paper, we present a critical analysis of an alternative approach to public sector driven ecosystem based service design. The analysis is based on a deductive review of earlier research on ecosystem based digital service design, and an inductive theory making based on a representative case study applying pre-commercial-procurement practices. The paper contributes to existing knowledgebase on ecosystem based digital service design. The managerial contribution is innovative approach to public sector service design process. The paper concludes with call for further research and practice on innovative digital service design models for public sector.

Herbal and dietary supplements (HDS) are used by over 50% of Americans, but commonly their use is not reported to healthcare providers. The aim of this study is to determine the prevalence of HDS use among patients with Chronic Liver Disease (CLD), with a focus on those using supplements known to cause hepatotoxicity. We accessed 61,951 individuals polled in the NHANES database between 2001-2011, which represented a population size of 1,763,482,931. 573 respondents reported a history of CLD (population size of 19,998,331.655). Of those 573 respondents, 41 respondents (population size 1,399,884) endorsed using HDS that are associated with causing hepatotoxicity, which are listed under the NIH complied master list. Our study demonstrates the need for better counseling of patients on the potential risks of these readily available products.

The aim of this study was to measure the changes caused by biofortified milk enriched with selenium, vitamin E and/or improved fatty acid profile in biochemical parameters of institutionalized older people. 132 institutionalized older persons were divided into four groups who received the following treatments: C= Control milk with 3.98 µmol/l vitamin E, 0.37 µmol/l selenium, 2.24 mmol/l CLA; A= Biofortified milk with 5.05 µmol/l vitamin E, 3.63 µmol/l selenium, 6.57 mmol/l CLA; O= Biofortified milk with 4.28 µmol/l vitamin E, 0.20 µmol/l selenium, 5.71 mmol/l CLA and AO=5.21 µmol/l vitamin E, 4.42 µmol/l selenium, 6.85 mmol/l CLA for 12 weeks. Consumption of AO or O milk decreased total cholesterol in 6.8 % (p=0.0429) and LDL in 10.6 % (p=0.0292). Participants who consumed O milk had a higher HDL (42.6±1.2 mg/dl) than those who consumed A (37.7±1.2 mg/dl, p=0.0047). The consumption of biofortified milk with selenium, vitamin E and CLA, resulted in a better lipid profile and higher plasma antioxidant levels in institutionalized elderly.

Background: Bacterial vaginosis (BV) is one the main causes of fluor albus in women which is found in 15 – 50% of all reproductive age in the world. Regimen therapy for bacterial vaginosis consists of antibiotics, but the recurrence rates remain high. Probiotics appear to have an effect on treating or preventing bacterial vaginosis recurrence. One of the probiotics is Lactobacillus crispatus. Methods: The result of online searching on Pubmed-MEDLINE, Scopus, EBSCOhost, Cambridge Core, ProQuest, Cochrane library, ClinicalTrials.gov, and Google Scholar databases had found 4 relevant articles included in this systematic review (n = 516 subjects), from which 3 articles were used in meta-analysis (n = 350 subjects). Results: The meta-analysis of effectiveness of L. crispatus probiotics intervention group compared to the placebo group showed a homogeneity in data (Q=2.170, df=2; p=0.338, Tau2=0.026). Meta-analysis showed the value of Q statistic was z value = -2.683; (p=0.007) and overall risk ratio is 0.694 (95% CI= 0.532 to 0.906) with p=0.007. This demonstrated that the group with L. crispatus probiotics had 0.694 times lower risk in having bacterial vaginosis recurrence compared to the placebo group. The test for overall effect found the time to recurrence of placebo group was shorter compared to probiotics group with overall mean time to recurrence between probiotics group and placebo group was -0.960±0.20 (Z value= -4.730; p

Background: Glabellar lines have social and psychological implication since oftentimes generate negative facial expressions that could be misunderstood, such as anger, anxiety, fear or sadness, and others related to extrinsic aging signs. Botulinum toxin type A has been used for more than 20 years in aesthetic medicine and one of many options to improve dynamic facial lines on upper third of the face, including glabellar lines. On April 2009. FDA approved abobotulinum toksin A (Dysport) as the latest botulinum toxin type A, a purified complex diluted with human serum albumin and lactose. Aim: The purpose of this study is to analyze the effectiveness of botulinum toxin type A (abobotulinum toxin A) as a therapy for moderate to severe glabellar lines. Methods: searching the electronic database Pubmed-MEDLINE, Scopus, ProQuest, Cochrane library, ClinicalTrials.gov, and Google Scholar, found five articles (n=1.134) included in qualitative and quantitave analysis. Result: Metaanalysis showed the value of Q statistic was z value = 9,079 (p=0,000). Glabellar lines improvement according to Glabellar Lines Scale were more prominent in botulinum toxin type A injection group compared to control group on the 30th day after botulinum toxin type A injection (relative risk 23,007; CI 95%,11,692 – 45,274). The result of the overall metanalysis showed that glabellar lines severity in the group with botulinum toxin type A injection was significantly improved compared to control group. Conclusion: Botulinum toxin type A 50 U (abobotulinum toxin type A) is effective in significantly improving glabellar lines severity compared to placebo group

Background: Onychomycosis is the most prevalent nail disease, accounting to about 50% of all onychopathies. The diagnosis is still a challenge considering that the gold standard complementary test (direct microscopy and culture) may be false negative in many cases. Objectives: The study aimed to evaluate the role of dermoscopy in diagnosis of onychomycosis in comparison with scrap microscopic examination, mycological culture and histopathology and to detect how close the dermoscopic examination to the previous diagnostic findings. Patients and Methods: The present study included 20 patients suffered from onychomychosis and they were subjected to clinical, KOH microscopic, dermoscopic, mycological and histological examinations. Results: Jagged edge with spikes, longitudinal striations, distal irregular termination and ruin appearance are dermoscopic criteria of onychomychosis observed in 75% of cases. KOH examination was positive in only 20% of patients showing spores and hyphae. Culture was positive in only 35% of cases with M. canis, T. violaceum, T. rubrum, Chaetomium sp. and Scopulariopsis brumpt and there were no difference between the dermoscopic features caused by different organisms. The histologic evaluation showed found septate hyphea and blastoconidias within the amorphous keratin of the nail in 65%. Conclusions: Dermoscopy may be considered an easy, helpful, quite simple, quick and inexpensive technique for increasing the diagnostic accuracy of onychomycosis and could be a practical and effective diagnostic tool when mycology is not readily available. Mycology can, on the other hand, be avoided when nail dermoscopy fail to show any diagnostic sign of onychomycosis.

A cross-sectional survey of older adults in independent living sought to find the impacts of the COVID-19 pandemic on their physical activity, socialization, and nutrition. A sample of 115 consenting adults ages 60 and older living in independent senior neighborhoods completed a lifestyle behavior survey during the height of the pandemic. The survey probed self-reported changes in the respondent’s physical activity, socialization, and nutrition. Chi-square (X2) goodness of fit tests of sample demographics suggests the results were representative of the local population of seniors in independent living environments. Point-biserial correlations produced significant changes in physical activity, socialization, and nutrition based on dwelling type and education level. Cross tabulations revealed significant relationships between physical activity and socialization to participant age and dwelling type. Overall, the project finds changes in physical activity, socialization, and nutrition that can help identify needed programs, initiatives, and resources to improve the resilience of seniors aging in place during pandemics and disasters.

Background: Androgenetic alopecia (AGA) is the most common form of hair loss in men, wherein systemic androgen disorders and genetic factors lead to progressive miniaturization of hair follicles due to changes in the duration of hair growth cycle, characterized by shorter anagen phase and longer telogen phase, resulting in smaller, thinner, and less pigmented terminal hair. The main goal of treatment in AGA is to prevent the miniaturization process. The therapeutic options commonly used in the treatment of male AGA, such as topical minoxidil and oral finasteride, have yet to produce satisfactory results. Currently, many new therapeutic modalities are being developed for AGA, one of which is platelet-rich plasma (PRP). Multiple growth factors secreted by PRP are thought to support hair growth by prolonging the anagen phase, preventing apoptosis, delaying induction of the catagen phase, triggering angiogenesis and increasing follicular vascularization. Methods: A systematic literature search was performed using PubMed-MEDLINE, Cochrane library, Embase, AMED, Clinicaltrials.gov, dan WHO ICTRP with the search terms “platelet rich plasma” and (“male androgenetic alopecia” or “male pattern hair loss”). Eight RCT were included in the qualitative synthesis and seven of them were included in the meta-analysis. Results: The overall SMD in hair density was -0.889 (95% CI: -1.630 – -0.147, p

Background: Atopic Dermatitis (AD) is a chronic, recurring inflammatory skin disease affecting 15-30% of childhood population. Its standard management entails the right skin care, avoidance of triggers, and topical corticosteroid treatment. However, long term topical corticosteroid usage produces significant side effects. Pathogenesis of AD is mainly influenced by the response of one of the main immune cells, type Th2. In AD, a change of intestinal microbiome composition takes place, which influences gut-skin axis. Probiotics are living organisms, which when consumed regularly and in adequate amount, promotes health benefits for the host. Probiotics modulate the immune system and cytokine production, causing a balance in Th1 and Th2 immune responses. This also regulates intestinal and skin microbiome homeostasis in AD. Methods: Online database research is conducted in Pubmed-MEDLINE, Cochrane Library, ProQuest, EBSCOhost, and Scopus. Seven articles are included in qualitative analysis (n = 701), between which four (n = 473) are included in quantitative analysis. Results: SCORAD Index meta-analysis with random effect model shows heterogenity test of I2 = 73% (p=0.003). Standardized mean difference is found to be -0.42 with CI 95%, -0.76 to -0.08. This shows a significant decrease in SCORAD Index in probiotic group, compared to placebo (p=0.01). Meta-analysis of serum IgE with fixed effect model shows heterogenity test of I2 = 0% (p=0.71). The standardized mean difference of IgE is -0.03 with CI 95%, -0.24 to 0.17. This shows a non-significant decrease on IgE serum in probiotic group, compared to placebo (p=0.74). Meta-analysis of serum IL-4 with fixed effect model shows heterogenity test of I2 = 0% (p=0.76). The standardized mean difference of IL-4 is -0.16, with CI 95%, -0.35 to 0.02. The result shows a greater but statistically non-significant decrease of serum IL-4 in probiotic group, compared to placebo (p=0.09). Conclusion: Probiotic supplementation may reduce AD lesion severity,…