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The study investigated the prevalence of domestic violence within the Effutu Municipality, it also examined how counselling programmes can assist in addressing domestic violence within the municipality. The study employed a cross sectional survey design and collected both quantitative and qualitative data. A simple random sampling technique was used in the selection of 300 respondents for the quantitative study, while purposive sampling technique was used in the selection of 12 interviewees for the qualitative aspect of the study. Quantitative data collected were analysed using descriptive and inferential analysis while qualitative data was analysed using content and thematic analyses. The study revealed that Christians and traditionalists differed in their views with regards to cultural and life-time perceptions about domestic violence. Additionally, educational level attained also influenced respondents’ perceptions on domestic violence against women in the Effutu Municipality. It was also revealed that though, there are institutions that offer services to reduce or forestall the incidence of domestic violence; both victims and perpetrators did not receive any counselling in any form. It is therefore recommended that Effutu municipal assembly hire professionally trained counsellors, and attach them to the various institutions that deal with issues bordering on domestic violence.

Medication-related issues are normal among home consideration patients who take numerous medications and have complex therapeutic narratives and medical issues. The objectives of home medicinal services administrations are to assist people with improving capacity and live with more noteworthy autonomy; to advance the customer’s ideal dimension of prosperity; and to help the patient to stay at home, evading hospitalization or admission to long haul care foundations. Home consideration is an arrangement of consideration given by gifted professionals to patients in their homes under the heading of a doctor. Home human services administrations incorporate nursing care; physical, word related, and discourse dialect treatment; and restorative social administrations. Doctors may allude patients for home social insurance administrations, or the administrations might be asked for by relatives or patients. The scope of home medicinal services benefits a patient can get at home is boundless. Contingent upon the individual patient’s circumstance, care can go from nursing care to particular restorative administrations, for example, research center workups. Basic judgments among home human services patients incorporate circulatory disease, heart disease, injury and poisoning, musculoskeletal and connective tissue disease and respiratory disease.

Epilepsy, a common chronic neurological disorder characterized by repeated, spontaneous seizures, also known as seizure disorder. Seizure related neuronal injury has been assumed to be mediated by glutamate, the excitatory amino acid, in the central nervous system that causes a sudden imbalance between the inhibitory and excitatory signals in the brain with glutamate, γ-aminobutyric acid (GABA), noradrenaline, serotonin, and dopamine. Since long term usage of antiepileptic drugs cause high incidence of pharmacoresistence and untoward side effects, attention has been paid in recent years to screen bioactive compounds from natural medicinal plants for treatment of several neurological disorders including Epilepsy. Keeping in view of relative importance of natural medicinal plants, the present study is mainly focused to characterize the anti-convulsant effect of Bacopa monnieri (BM), an Indian herb which is being extensively used in Ayurvedic treatments related to neurological complications. The present study is designed to assess the neurotoxicity of Pentylene tetrazole (PTZ), an epileptic compounds, on the Glutamate metabolism and Amino transferases in different brain regions (Cerebral cortex, Cerebellum, Pons medulla and Hippocampus) of rat and to explore the possible antiepileptic effect of different extracts (Ethanol, n-Hexane, Chloroform, Ethyl acetate, n-Butanol and Aqueous extracts) of BM in comparison with Diazepam (DZ) (Reference control). The activities of glutamate dehydrogenase (GDH), glutamine synthetase (GS) and glutamine content were decreased in different regions of brain during PTZ induced epilepsy which were increased in epileptic rats pretreated with different extracts of Bacopa monnieri except EAE and AE. Glutaminase activity was increased in PTZ induced epilepsy and decreased on pretreatment with all the extracts of BM except AE. In addition aspartate (AAT) and alanine aminotransferase (ALAT) activity levels were increased during PTZ induced epilepsy when compared with normal control and levels were reversed on pretreatment with different extracts of BM. Recoveries of these parameters during…

Ratio derivative spectrophotometric method has been developed for the simultaneous estimation of Clonazepam and Paroxetine hydrochloride in pharmaceutical dosage form. In this method, the overlapping spectra of Clonazepam and Paroxetine hydrochloride were well resolved by making use of the first-derivative of the ratios of their direct absorption spectra. The derivative ratio absorbance of Clonazepam and Paroxetine hydrochloride were measured at 312.28 nm and 304.88 nm, respectively for their quantification. Clonazepam and Paroxetine hydrochloride were determined in the concentration range of 5-30 µg/ml and 10-60 µg/ml respectively. The linear regression analysis for the calibration plots produced r2= 0.9956 and r2= 0.9994 for Clonazepam and Paroxetine hydrochloride respectively. The precision, accuracy, limit of detection and limit of quantitation of the method were validated according to the ICH guidelines. The results indicate that the method is suitable for the routine quality control testing of marketed tablet formulations.

Background: Mediator complex subunit 12 (MED12) is a part of the mediator complex, which is believed to regulate transcription. Our recent study showed that MED12 is mutated at high frequency and with different mutation frequencies in Senegalese women with uterine fibroids. However, the status of mutations has not been correlated to the epidemiological factors that are implicated in uterine fibroids. Methods: This study aimed to analyze status of MED12 mutations in Senegalese population. MED12 was sequenced in tumoral tissues and blood samples of 54 Senegalese women with uterine fibroids. Clinical and pathological data were obtained from the patient’s records and other parameters were recorded. Mutation Surveyor software version 5.0.1, DnaSP version 5.10, MEGA version 7.0.26 and Arlequin version 3.5.1.3 were used to determine the level of mutations and genetics parameters. To estimate the genetic variation according to the epidemiological parameters, the index of genetic differentiation (Fst) and the genetic structure like analysis of molecular variance (AMOVA) were determined with Arlequin software version 3.5.1.3. The significance level (P-value) was 0.05. Results: Our results showed that MED12 is mutated at 88.89% (48/54) only in tumor tissues. The variants frequencies were not similar to those found in the Finnish populations. The Chi2 test indicates a statistically significant difference for the variants c.130G>C, c.130G>A, c.131G>A and for the Intronic Variant Site (p

Background The powders of Ni-Cr Nano ferrites were synthesized with the chemical formula, NiCrXFe2−XO4 (Where X = 0.1, 0.3, 0.5, 0.7, 0.9 and 1.0) by using citrate-gel auto combustion technique. The structural characterization was investigated by X-Ray Diffractomerter (XRD). X-ray analysis shows that the samples are cubic spinel structure (single phase) without any impurity peak and average crystallite size was in the range of 8.5-10.5nm. The dielectric measurements were carried out as a function of frequency and composition (X) at room temperature in the range of 20Hz-2MHz. The real part of dielectric constant (ε’) and dielectric loss factor (tan δ) showed a decreasing trend with increasing field frequency. The ac conductivity (σac) is calculated from the dielectric measurements and it is increased with the increase of frequency. The composition dependent dielectric parameters are reported.

Chitosan microspheres (CS) prepared by water-in-oil emulsion/glutaraldehyde cross-linking-evaporation and simple coacervation/cross-linking with sodium tripolyphosphate were covalently linked to diosgenin hemiesters. The diosgenin content found using elemental analysis was ca. 6 to 42 wt-% and it showed dependence on the type of diosgenin hemiesters and on the method of preparation of the CS microspheres. Fourier transform infrared spectroscopy confirmed the hydrophobic functionalization of CS with the diosgenin hemiesters by amide bond formation. The effect of CS modification with diosgenin on the thermal properties was also studied using differential scanning calorimetry. Microsphere sizes determined using optical microscopy ranged from 60 to 700 um, while scanning electron microscopy depicted morphology dependent on the selected method to obtain CS microspheres. In vitro release studies performed in aqueous medium indicated a drug release dependence on the diosgenin hemiester linkers, the steroid content and the acidity of the solution. Sustained diosgenin release in acidic aqueous solution (pH 6.0) reached from 34 to 81% after 48 h.

Background: Ovarian fibrosarcoma is a rare malignant tumor that should be distinguished from benign fibrous ovarian tumors and other malignancies, as it has a predilection for early and aggressive metastasis. Case: A 52-year-old woman presented with a large adnexal mass comprised of atypical spindle cells with increased mitotic activity, high Ki-67 index, and positive vimentin staining, consistent with primary ovarian fibrosarcoma. The patient required multiple laparotomies for large volumes of recurrent, rapidly growing disease. She died 15 months after initial surgery. Conclusion: Ovarian fibrosarcoma is an important diagnostic consideration when evaluating adnexal masses. Further study is required to clarify the impact of potential prognostic factors and establish optimal management and treatment.

Any quantum state can be described by a vortex, which is mathematically a multi-vector and physically a united-measure. When the vortex formulation of quantum physics is introduced, Hamilton principle keeps its core position in physical analysis. While the global characteristics are described by Lagranrian function for dynamics and double complex core function for stable states, Schrödinger equation and gauge symmetries reveal local characteristics. The vortex-based physics provides a new unified understanding of wave-particle duality and uncertainty, quantum entanglement and teleportation, as well as quantum information and computation, with setting discrete quantum states into continuous space-time for keeping concordance of methodology in processing micro-particle and macro-galaxy. Two fundamental experiments are suggested to correct and verify the physical formulation.

This study was conducted to produce empirical evidence of validity and reliability of a set of questionnaire. Questionnaire drawn from the results of previous studies and the validity of the tests will determine whether all aspects of the construct domain were represented, thus ensuring the high objectivity level of the questionnaire. In addition, an alternative approach was used to assess the discriminant validity, using heterotrait-monotrait ratio of correlations. The study empirically proves that the questionnaire used is unchanged by culture. This is important because if not, its use will be restricted to a population in which the questionnaire was developed.