Recent Articles

Cancer is one of the harmful leading causes of death worldwide. Several synthetic agents have been used to cure the disease but they have their adverse side effects, low-hilling potential and toxicity.Present Article reviewed three important medicinal plants i.e.- Taxus baccata L. Or Taxus baccata Thunb., Catharanthus roseus(L.) G.Don and Annona muricata L. which traditionally used since ancient time for the treatment and prevention of Cancer and Tumor in Sothern, Northern-east and Himalayan region of India. Having active phytochemical constitutents Taxanes- Alkaloids(Taxol and Taxotere), Larotaxel,nab-Paclitaxel present in T. baccata L. Or T.baccata Thunb. and Vinca-Alkaloid as Vinblastine, Vincristine, Vinorelbine, Vinflunine, catharanthine and vindoline alkaloids in Catharanthus roseus(L.) G.Don, as well as Muricin J, Muricin K, Muricin L, Cinnamic acid derivative, Coumaric acid hexose, Annomuricin A, Annomuricin B, Annomuricin C, Annomuricin E, Annomutacin, Annhexocin, Muricatocin A, Muricatocin B, Muricatocin C, Giganletronenin, Annonacin A, Annopentocin A, Annopentocin B, Annopentocin C etc. present in A muricata L. This report also revealed the ethno-botanicaly and biological activities of active principles of these plants that will help in noval drug discovery, noval new active phytochemical constituents of anti-cancer and anti-tumor formulations and development of pharmacopial standareds.

Standardization is used to describe all measures under taken during the manufacturing process and quality control of drug assuring its reproducible quality. Most of the traditional medicine are effective but still they lack in its standard parameters. Therefore, we need to develop standard techniques to standardize and validate herbal formulations. The drug Habb-e-Sara Khas is therapeutically useful in the treatment of Sara Khas (Epilepsy and Infantile epilepsy). The drug Habb-e-Sara Khas was prepared in three different batches as per the guidelines of National Formulary of Unani Medicine(Part-VI), Present study is aimed to evaluate the pharmacopoeial standards using physico-chemical parameters; HPTLC fingerprints, quality control and assurance parameters, using WHO guideline to ascertain the quality of drug. The physico-chemical data showed that the drug contain moisture(1.89%), total ash (5.43%),acid in-soluble(1.06%), alcohol and water soluble extractive matter (19.39%) and(60.34%),pH(1% solution) (5.93),pH(10% solution)(5.67), ASSE(18.07%) and CSSE (17.43%), Bulk density of granules(0.4989) and the TLC/HPTLC finger prints showed various spots at 254nm, 366nm and visible light (V-S reagent). The quality control study revealed the absence of microbial load, aflatoxins, heavy metals and pesticide residues, The evaluated standards will very much useful for laying the phamacopoeial standards of Habb-e-Sara Khas and also in providing the quality medicine to needful human beings.

Curcumin [(1E,6E)-1,7-bis (4-hydroxy- 3-methoxyphenyl) -1,6- heptadiene-3,5-dione)], a polyphenolic compound derived from dietary spice turmeric, has numerous biological and pharmacological activities. It is currently being used for treating several disorders, including cancer. Keeping in view its importance, the curcumin was embedded in the silica nanoparticles prepared by reaction of Tween-40, n-Butanol, triethoxyvinylsilane and 3-aminopropyltriethoxysilane using water as solvent. After completion of reaction, the nanoparticles were obtained by dialysis of the reaction mixture. The nanoparticles were characterized by SEM, TEM, DLS and XRD analyses. The SEM, TEM and DLS analysis shows the average particle size to be 70nm, 66 nm and 75.72nm respectively. Further in-vivo studies were conducted on wistar rats to determine the maximum tolerance dose (MTD) of nanoparticles and study the anti-cancer potential by tumor regression analysis. The MTD was found to be 10 mg/kg body weight of wistar rats and curcumin-doped ORMOSIL nanoparticles in comparison with pure curcumin revealed the highly significant results in tumor regression in EAT induced tumor model.

The article gives the results of studies of the effect of soil and fertilizer treatment on the productivity of winter wheat in the Ganja-Gazakh zone of Azerbaijan. The positive effect of fertilizers on plants of winter wheat is manifested only in well-cultivated soils with a reaction of the environment close to neutral. At the same time it is proved that between the intensity of the application of mineral fertilizers and the productivity of grain crops around the world, a close direct dependence is established. Consequently, the highest yield of grain here was obtained in the variant of dung 10t / ha + N90P90K60 57.1 c / ha, an increase of 24.3 c / ha or 74.1%, where the yield increase by 40-50% is due to the application of fertilizers

With the correct process management, low-intensity irrigation allows not only to drastically reduce water consumption for irrigation of agricultural crops, but also to provide the necessary microclimate for plants and the supply of water and fertilizers in the required amount directly to the root zone of plants, which contributes to the earlier entry of plants into the season fruiting and increased productivity while reducing water per unit of crop and reducing production costs. For this, we have developed a perfect safe technological system of automated irrigation based on IDAD with automated control of the controlled potential moisture supply of the plant, an optimized irrigation regime taking into account the controlled soil and agroclimatic parameters that affect the growth and development of the plant phase, while maintaining the ecological environment that contributes to obtaining a guaranteed and high-quality yield per unit area meeting the requirement of mi ovyh standards. The system of low-intensity irrigation created by the results of the study compared to traditional surface irrigation methods is more technologically demanding and in the remote areas from settlements it is difficult to provide qualified service; to ensure their possible efficiency, they require complex automation of the irrigation technological process.

Yoruba traditional healing system has being in practice for several centuries, yet, there are still certain complexities which set confusion in understanding its conceptualization. Due to lack of enough information about the practice, cynicism, religious bigotry against the practice and over-westernization of healthcare system in Yoruba society, basic features of Yoruba traditional healing system are still obscured. Conceptualization of the healing is narrowed and reduced to fetish; its epistemology is linked with Satan, and organization of Yoruba traditional healing is regarded as unscientific among other complexities suffered by the healing system. This continues to hamper the acknowledgment of its contributions to sustainable healthcare development. Through ethnographic data collection techniques using key informants’ interviews, observation, case study analysis and ethno-botanical survey conceptualization of traditional healing in Yoruba worldviews is examined. Despite the wave of social change influencing the practice of healing in Yoruba society, Yoruba traditional healing system is still resilient, rational and scientific. It features organization of service, providing all- inclusive health caring; with professionalization and specialization in health care service. Since Yoruba healing system is indigenous to the people, it has to be sustained by providing enough information that can explain and contextualize its practices.

Background: Drug-induced hepatotoxicity is the most prevalent side effect that lead to the failure of new drug candidates or withdrawal from the market and is a significant clinical problem that contributes more than 50% of acute liver failure. Objective: The objective of this study is to assess the prevalence and associated risk factors of drug-induced hepatotoxicity among TB or TB/HIV co-infected patients in ACSH, Mekelle, Ethiopia. Method: A retrospective cross sectional method was conducted in ACSH on the prevalence and associated risk factors of drug-induced hepatotoxicity among TB or TB/HIV co-infected patients from January to April 2019 E.C. Result: Out of 164 participants, 16 of them had developed hepatotoxicity. After bivariate logistic regression analysis, Predictor variables with p-value < 0.25 by bivariate analysis were analysed using multivariable logistic regression analysis and Art regimen [AOR=0.038, (CI95%) (0.002-0.846); p=0.038], CD4 count less than 50 [AOR=0.031, (CI95%) (0.00-0.64); p=0.08] and disseminated of TB [AOR=0.042, (CI95%) (0.001-0.88); p=0.030] as independent predictors of drug induced hepatotoxicity. Conclusion: The prevalence of DIH was 9.8 %. Results suggest that in the presence of disseminated pulmonary TB and CD4 count in HIV positive patients and those who are on Efavirenz based ART medication should be closely monitored for the occurrence of hepatotoxicity to prevent morbidity and mortality.

Background: Cerebrovascular accident (CVA) is a problem that refers to a group of conditions that affect the circulation of blood to the brain. The objective of this study was to identify factors related to cerebrovascular accident patients in the Ayder Comprehensive Specialized Hospital. Method: A retrospective cohort study design was conducted in the Ayder Comprehensive Hospital from January 2015 to August 2016 and followed for a total of 20 days during the admission period. Data was collected from a database of electronic medical records and medical charts using a structured data extraction tool. Kaplan-Meier, log rank test and Cox-proportional hazard regression were used. STATA V.13 program was used for data entry, cleaning and analysis. Result: From 292 CVA case patients, 42(14.4%) died and (80.95%) were died with in the 7 days of hospital stay and their median survival time was also 7 days. Factors associated with CVA mortality were: positive history of hypertension (HR=4.8, 95%, CI= 1.486 – 16.018), positive history of diabetes mellitus (HR=2.0, 95%, CI= 1.086 – 3.789), Stroke sub type as haemorrhagic (HR= 2.1, 95%, CI= 1.070 – 4.160), admitted in intensive care unit (HR= 2.48, 95%, CI= 1.166 -5.306) and increased age (HR= 5.1, 95%, CI= 1.725 – 15.487) Conclusion: The risk rate of patients at an earlier time was high, and there was more death in the intensive care unit than any other medical wards. Hypertension was the most common risk factor for both types of cardiovascular accidents. Ischemic stroke subtype, diabetes mellitus and rising age were also associated survival factors.

The study was conducted in Adami Tulu Jido Kombolcha (ATJK) district of the East Shoa Zone Oromai Region, Eethiopia, with the objectives to assess the existing status of feed resource under climate change and examine chemical composition. Feed sample from grazing lands (protected communal (PC), protected private (PP) and unprotected communal (UnPC) and crop residues were used for chemical composition analysis (23 from the natural pasture (NP) and 48 from crop residues (CRs). Out of 23 herbaceous species identified in ATJK district, Cynodon dactilon in ATJK district was the dominant grass species. The average mean DMY (ton ha-1) of grass obtained from PPGL (2.43) and PCGL (2.36) was significantly (P

Exports play a crucial role in the growth of any economy. It is an avenue for raising national income of the country. The paper was entitled with improving Ethiopian export revenue: lesson from our experience and best practices of selected emerging economies. The overall objective of this study is to analysis strength, weakness, opportunities and treats of export business in Ethiopia and evaluate selected developed and developing countries export promotion strategy, development programs, policies and practices. For attainment of broad objective the researcher adopted qualitative research approach. Secondary data used for the study was collected from printed and online internet reports through structured documentary review. Study was used sample from developing and developed countries in Africa and Asia. The sampling method this adopted was systematic sampling. The study sample determination was two folds; large know exporter in Ethiopia and counties that have better experience in export business from both economy developing and developed. The study indicates that in the sector there is number of opportunities which is important to increase the revenue of export business, one is expansion of universities and industrial parks in the nation which may solve the threat of skilled labor force for industry sector and increasing unemployment problem respectively.