The role of Zi2 during neural tube and neural crest development

The role of Zi2 during neural tube and neural crest development

Gerald Muca*

Department of Morfofunctional Modules, Faculty of Veterinary Medicine, Agricultural University of Tirana, Koder Kamez, 2021 Tirana-Albania

Global Journal of Molecular Biology

The transcription factor Zic2 is member of Zic family, at early stages it has been involved in several processes during embryonic development and later on in morphogenesis and organogenesis. An important role has been attributed to Zic2 during the development of the neural system. It has been involved in neural tube and neural crest formation. Both process structures will form the central and peripheral neural system. Mutation of Zic2 provokes holoprosencephaly in humans and in mouse also spina bifida. To date, there is not well elaborated the specific mechanisms under which Zic2 affect neural tube formation and the differences may exist between mouse and human phenotype. Almost the same ambiguity is for the specific role of Zic2 during neural crest development. Here is given are resumed latest studies and are given new insight about the role of Zic2 in these two processes and its new target genes.

Keywords: Zic2; neural tube; neural crest; cell proliferation; development

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How to cite this article:
Gerald Muca.The role of Zi2 during neural tube and neural crest development. Global Journal of Molecular Biology, 2019, 2:6. DOI: 10.28933/gjmb-2019-01-1605

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