Ultrafiltration (UF) Effectiveness on intradialytic hypertension (IDH) in chronic hemodialysed patients in a nephrology unit in Dakar: UF-IDH clinical trial


Ultrafiltration (UF) Effectiveness on intradialytic hypertension (IDH) in chronic hemodialysed patients in a nephrology unit in Dakar: UF-IDH clinical trial


Ba Bacary 1, Faye Moustapha 1, Keita Niakhaleen 1, Lemrabott Ahmed Tall 1, Seck Sidy Mohamed 2, Faye Maria 1, Mbengue Mansour 1, Diagne Seynabou 1, Ba Mamadou Aw 1, Dieng Ahmed 1, Kane yaya 3, Diouf Boucar 1, Niang Abdou 1, Ka Elhadji Fary 1

1Department of Nephrology, Dialysis and Renal Transplantation of Aristide Le Dantec University Hospital, Cheikh Anta Diop University, Dakar, Senegal. 2Department of nephrology and dialysis of the Military Hospital of Ouakam, Gaston Berger University of Saint Louis, Senegal. 3Departement of nephrology and dialysis of the regional hospital of Ziguichor, Assane Seck university of Ziguinchor, Senegal.


Introduction

Progressive ultrafiltration (UF) could improve IDH. The aim of this work was to evaluate the effectiveness of progressive UF in the management of IDH.

Methods

This randomized clinical trial in two groups: interventional group A (UF, n = 12) and control group B (n = 12), was conducted in chronic hemodialysis patients with IDH. A first phase of cross-sectional collection of BP before and after dialysis, during 2 weeks, made it possible to obtain this cohort of 24 patients. A progressive decrease in basal weight of 0.25 kg per session as a function of hemodynamic tolerance was achieved in group A. The primary endpoint, the proportion of patients with disappearance of IDH, was assessed at baseline end of the 4th and 8th week.

Results

At the 4th week, the IDH disappeared in 83.3% and 41.7% of the patients of the group A and B respectively with a hazard ratio (HR) at 0.29; IC 95 = [0.14-0.59]; p = 0.035. At the 8th week, the IDH was missing in 72.7% and 66.7% of the patients of the group A and B respectively with a HR at 0.76; IC 95 = [0.58-1.00]; p = 0.75. In addition, the decrease in basal weight was associated with the occurrence of side effects (p = 0.0001) with a HR of 5 [1.45-7.27]. UF discontinuation was required in 4 patients in group A (36.4%).

Conclusion

Progressive UF was associated with a significant reduction in the prevalence of IDH in our patients at week 4.


Keywords: intradialytic hypertension – ultrafiltration – hemodialysis – Dakar.

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How to cite this article:

Ba Bacary, Faye Moustapha, Keita Niakhaleen, Lemrabott Ahmed Tall, Seck Sidy Mohamed, Faye Maria, Mbengue Mansour, Diagne Seynabou, Ba Mamadou Aw, Dieng Ahmed, Kane yaya, Diouf Boucar, Niang Abdou, Ka Elhadji Fary. Ultrafiltration (UF) Effectiveness on intradialytic hypertension (IDH) in chronic hemodialysed patients in a nephrology unit in Dakar: UF-IDH clinical trial. Global Journal of Urology and Nephrology, 2021, 4:25. DOI: 10.28933/gjun-2020-05-1405


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