Research Article of Global Journal of Urology and Nephrology
Intrinsic factors affecting incidence of urolithiasis in diabetic patients –A preliminary case-control study
Kalpesh Saswade1, Maria Tom2, Lekshmi Hareendran2, Vishnu Kamalasanan2, Ganesh Sonawane1, Rohan Kumar1, Praveen Singh1, Biju S Pillai3, Krishna Moorthy H4
1Resident, Department of urology, Lourdes Hospital, Kochi, Kerala, India; 2Department of Pharmacy Practice, St. Joseph’s college of pharmacy, Cherthala, Kerala,India; 3 Consultant, Department of urology, Lourdes Hospital, Kochi, Kerala, India; 4Senior Consultant and Head, Department of urology, Lourdes Hospital, Kochi, Kerala, India
There has been a steep rise in incidence of urolithiasis in recent years. Recent studies have revealed an increased prevalence of urolithiasis in patients with Diabetes Mellitus (DM). The role of various intrinsic factors of diabetic patients such as Body Mass Index (BMI), level of glycemic control, baseline kidney function and mode of treatment of DM which can influence incidence of urolithiasis still remains uninvestigated. This case control study was taken up to evaluate these intrinsic factors affecting the incidence of urolithiasis in patients with DM. The case group included diabetic patients with urolithiasis and the control group included age matched diabetic patients without urolithiasis. We concluded that Higher BMI and higher serum creatinine level in diabetic patients were associated with increased incidence of urolithiasis whereas other intrinsic factors such as age, sex, duration of DM and the level of glycemic control did not have any influence on it.
Keywords: Diabetes mellitus, Urolithiasis, BMI, Intrinsic factors
How to cite this article:
Kalpesh Saswade, Maria Tom, Lekshmi Hareendran, Vishnu Kamalasanan, Ganesh Sonawane, Rohan Kumar, Praveen Singh, Biju S Pillai, Krishna Moorthy H. Intrinsic factors affecting incidence of urolithiasis in diabetic patients –A preliminary case-control study. Global Journal of Urology and Nephrology, 2020, 3:24. DOI: 10.28933/gjun-2020-06-1805
1. Stamatelou KK, Francis ME, Jones CA, Nyberg Jr LM, Curhan GC. Time trends in reported prevalence of kidney stones in the United States: 1976–1994. Kidney International, 2003; 63(5): 1817-1823.
2. Johnson CM, Wilson DM, O’Fallon WM, Malek RS, Kurland LT. Renal stone epidemiology: a 25-year study in Rochester, Minnesota. Kidney International, 1979; 16(5): 624-631.
3. Hiatt RA, Dales LG, Friedman GD, Hunkeler EM. Frequency of urolithiasis in a prepaid medical care program. American Journal of Epidemiology, 1982; 115(2): 255-265.
4. Taylor EN, Stampfer MJ, Curhan GC. Diabetes mellitus and the risk of nephrolithiasis. Kidney International, 2005; 68(3): 1230-1235.
5. Meydan N, Barutca S, Caliskan S, Camsari T. Urinary stone disease in diabetes mellitus. Scandinavian Journal of Urology and Nephrology, 2003; 37(1): 64-70.
6. Beck-Nielsen H, Groop LC. Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus. The Journal of Clinical Investigation, 1994; 94(5): 1714-1721.
7. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. The Lancet, 2005; 365(9468): 1415-1428.
8. Sakhaee K, Adams-Huet B, Moe OW, Pak CY. Pathophysiologic basis for normal uricosuric uric acid nephrolithiasis. Kidney International, 2002; 62(3): 971-979.
9. Abate N, Chandalia M, Cabo-Chan Jr AV, Moe OW, Sakhaee K. The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. Kidney Inter-national, 2004; 65(2): 386-392.
10. Gutman AB. Uric acid nephrolithiasis in gout: predisposing factors. Annals of Internal Medicine, 1967; 67(6): 1133-1148.
11. Daudon M, Traxer O, Conort P, Lacour B, Jungers P. Type 2 diabetes increases the risk for uric acid stones. Journal of the American Society of Nephrology, 2006; 17(7): 2026-2033.
12. Weinberg A, Patel C, Chertow G, Leppert J. Diabetes severity and risk of kidney stone disease. The Journal of Urology, 2013; 189(4): 27-28.