Research Article of International Journal of Bioscience and Medicine
Thaumatococcus daniellii Benn. (Marantaceae) Leaf Methanol Extract Possessed Hepatoprotective Effect Against Acetaminophen-induced Liver Injury in Albino Rats
Ukwubile CA, 2Musa YD and 2Troy SM
1Department of Science Laboratory Technology, Biology Unit, School of Science and Technology, Federal Polytechnic Bali, Nigeria.
2Department of Pharmacognosy, Faculty of Pharmacy, University of Maiduguri, Nigeria.
[Background]Acetaminophen or Paracetamol is widely used as analgesic and antipyretic or antimalarial drug, but at high dose it leads to undesirable side effects, such as hepatotoxicity. [Objective]This present study demonstrates the in vivo hepatoprotective effect of Thaumatococcus daniellii against acetaminophen induced liver toxicity. [Methods] Acetaminophen- induced liver injury was evaluated by an increase in serum AST (or SGOT), ALT (or SGPT), ALP activity and bilirubin level accompanied by significant decrease in albumin level. [Results] Acetaminophen hepatoxicity was manifested by an increase in lipid peroxidation, depletion of reduced glutathione (GSH) and catalase activity in liver tissue. Oral administration of the plant extract protects the rats against acetaminophen induced liver injury by increased lipid peroxidation, restored altered serum marker enzymes and antioxidant level to normal liver morphology.[Conclusion]The results showed that T. daniellii leaf extract displayed significant liver healing efficacy against acetaminophen induced hepatotoxicity in rats. The result further affirm the use of the plant as an ethno-medicinal prescription for liver related injury.
Keywords: Acetaminophen, hepatoprotective, Thaumatococcus daniellii, liver injury.
Abbreviations Used： ALT = Alanine aminotransaminase or serum glutamic pyruvic transaminase, AST = Aspartate aminotransaminase or serum glutamic oxaloacetic transaminase, ALP = alkaline phosphatase
How to cite this article:
Ukwubile CA, Musa YD and Troy SM. Thaumatococcus daniellii Benn. (Marantaceae) Leaf Methanol Extract Possessed Hepatoprotective Effect Against Acetaminophen-induced Liver Injury in Albino Rats. International Journal of Bioscience and Medicine, 2017; 1:4. DOI: 10.28933/ijbm-2017-09-2002
 Benthan G, Hooker JO. Genera Plantarium “Thaumatococcus daniellii. Biodiversity library, 2008, 3: 652.
 Cohen SD, and Khairallah EA. Selective protein alkylation and acetaminophen-induced hepatoxicity: Drug Metabolism Reviews, 2007, 29:59-77.
 Kozer E, Evans S, Barr J, Greenberg R, Soriano, I, Bulkowstein M, Petrov I, Chen-Levi Z, Barzilay B. and Berkovitch M. Glutathione dependent enzymes and antioxidants status in erythrocytes from children treated with high dose Paracetamol. British Clinical pharmacology, 2003, 55(3): 234-240.
 Lim TK. (2012). Edible medicinal and non-medicinal plants fruits .Springer Science Business media, 2012, Volume 3:34-38.
 Savides MC and Oehme FW. The molecular Toxicology of Acetaminophen. Journal of Applied Toxicology, 2013, 3: 95-111.
 Onwueme IC, Onochie BE, Sofowora EA. Cultivation of Thaumatococcus daniellii the sweetener. Word crops, 1979, 3:106-111.
 Pauli-Magnus C, Streger B, Meicer Y. Kullakublick GA, Meier PJ. Enterophenotic transport of bile salts and genetics of Cholestasis: Journal of Hematology, 2005, 43(2): 342 -367.
 Raja M and Prince SM. Comparative effects of Aegle marmelos extract and alpha-tocophenol on serum lipids, lipids peroxide and cardiac enzyme levels in rats with isoproterenol-induced myocardial infarction. Singapore Medical. Journal, 2005, 46(2): 78.
 Russmann S, Gerd A, and Grattagliano I. Current concepts of mechanism in drug-induced hepatoxicity. Current Medicinal Chemistry, 2009, 16(23):3041-3053.
 Sachdewa A, Raira P, Srivastava AK and Khemani LD. Managements of Neurocytocercosis with an emphasis on low bilirubin. Environ. 2001, 22(1): 53-7
 Lowry OH., Rosenbrough NJ, Farr AL and Randall RJ. Protein measurement with the poly phenol reagents. Journal of Biological Chemistry, 1951, 193:265-275.
 Summary Notification” of liver diseases. Journal of Physiology, 2008, 34:06-04.
 Vermeulen NP, Bessems JG and Vandestrect R. Mechanism of protection of Lebenzarit against Paracetamol toxicity in rat hepatocytes. Drug Metabolism Reviews, 1992, 24: 367-407.
 Wiessema JH, Lean B. World economic plants: A standard reference. CRC Press, 2009: Pp.661.
 World Checklist of Selected Plant families Volume 44: Pp. 222.
 Zaher H, Butters JT, Ward, JM, Brono UK, Lucas AM, Stem ST, Chen SD and Cronzalex, FJ. Tumor-derived exosome modules P.D-L1 expression in monocytes. Toxicology and Applied Pharmacology, 2012, 152 (1): 193-199.
This work and its PDF file(s) are licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.