Thaumatococcus daniellii Benn. (Marantaceae) Leaf Methanol Extract Possessed Hepatoprotective Effect Against Acetaminophen-induced Liver Injury in Albino Rats

Thaumatococcus daniellii Benn. (Marantaceae)  Leaf Methanol Extract Possessed Hepatoprotective Effect Against Acetaminophen-induced Liver Injury in Albino Rats

Ukwubile CA, 2Musa YD and  2Troy SM

1Department of Science Laboratory Technology, Biology Unit, School of Science and Technology, Federal Polytechnic Bali, Nigeria.
2Department of Pharmacognosy, Faculty of Pharmacy, University of Maiduguri, Nigeria.

International Journal of Bioscience and Medicine

[Background]Acetaminophen or Paracetamol is widely used as analgesic and antipyretic or antimalarial drug, but at high dose it leads to undesirable side effects, such as hepatotoxicity. [Objective]This present study demonstrates the in vivo hepatoprotective effect of Thaumatococcus daniellii against acetaminophen induced liver toxicity. [Methods] Acetaminophen- induced liver injury was evaluated by an increase in serum AST (or SGOT), ALT (or SGPT), ALP activity and bilirubin level accompanied by significant decrease in albumin level. [Results] Acetaminophen hepatoxicity was manifested by an increase in lipid peroxidation, depletion of reduced glutathione (GSH) and catalase activity in liver tissue. Oral administration of the plant extract protects the rats against acetaminophen induced liver injury by increased lipid peroxidation, restored altered serum marker enzymes and antioxidant level to normal liver morphology.[Conclusion]The results showed that T. daniellii leaf extract displayed significant liver healing efficacy against acetaminophen induced hepatotoxicity in rats. The result further affirm the use of the plant as an ethno-medicinal prescription for liver related injury.

Keywords: Acetaminophen, hepatoprotective, Thaumatococcus daniellii, liver injury.

Abbreviations Used: ALT = Alanine aminotransaminase or serum glutamic pyruvic transaminase, AST = Aspartate aminotransaminase or serum glutamic oxaloacetic transaminase, ALP = alkaline phosphatase

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How to cite this article:
Ukwubile CA, Musa YD and  Troy SM. Thaumatococcus daniellii Benn. (Marantaceae) Leaf Methanol Extract Possessed Hepatoprotective Effect Against Acetaminophen-induced Liver Injury in Albino Rats. International Journal of Bioscience and Medicine, 2017; 1:4. DOI: 10.28933/ijbm-2017-09-2002


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