Dasatinib-Induced Colitis in a Patient with Chronic Myeloid Leukemia (Chronic Phase)

Dasatinib-Induced Colitis in a Patient with Chronic Myeloid Leukemia (Chronic Phase)

Lubna M. Riaz1#, Khaled M. Galal2, Radwa M. Hussein2, Abdulqadir J. Nashwan1, Mohamed A. Yassin1#

1. Hematology Section/Medical Oncology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
2. Department of Pharmacy, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

International-Journal-of-Case-Reports-2d code

Chronic myeloid leukemia (CML) is a Philadelphia (Ph) chromosome-positive myeloproliferative neoplasm. The molecular consequence of reciprocal translocation t(9;22)(q34;q11) is the generation of the BCR–ABL fusion gene, which encodes a constitutively active tyrosine kinase signaling protein. The tyrosine kinase is responsible for the leukemia phenotype through the constitutive activation of multiple signaling pathways involved in the cell cycle and in adhesion and apoptosis. Dasatinib is an oral BCR-ABL tyrosine kinase inhibitor (TKI) which is mainly used for treating CML patients with resistance or intolerance to Imatinib. Dasatinib has several significant adverse reactions and gastrointestinal side effects including colitis. We report a case of a 33-year-old male, diagnosed with CML (Chronic Phase) who received Dasatinib as second-line therapy and developed chronic diarrhea and colitis attributed to Dasatinib and improved after stopping it.

Keywords: Dasatinib, Chronic myeloid leukemia, Colitis

#First and last authors equally contributed

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How to cite this article:
Lubna M. Riaz, Khaled M. Galal, Radwa M. Hussein, Abdulqadir J. Nashwan, Mohamed A. Yassin. Dasatinib-Induced Colitis in a Patient with Chronic Myeloid Leukemia (Chronic Phase). International Journal of Case Reports, 2018 3:43. DOI:10.28933/ijcr-2018-10-2401


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