Temozolamide-Associated Pancytopenia in a Patient with Glioblastoma Multiforme


Temozolamide-Associated Pancytopenia in a Patient with Glioblastoma Multiforme


Kubra Bozkurt¹ , Esra Terzı Demırsoy2, Esma Turkmen Bekmez3, Dıncer Aydın4

1Department of İnternal Medicine, University of Health Sciences, Kocaeli Derince Training and  Research Hospital, Kocaeli, Turkey; 2 Department of Hematology, University Health Sciences, Kocaeli Derince Training and Research Hospital , Kocaeli, Turkey; 3Department of Medical Oncology, University of Health Sciences, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey; 4Department of Medical Oncology, University of Health Sciences, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey


International-Journal-of-Case-Reports-2d code

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor. GBM treatment is a combined modality approach involving maximum surgical resection, adjuvant postoperative radiation and adjuvant chemotherapy treatment.There is a greater risk of hematological toxicity in concurrent temozolomide and radiation therapy. We reported that pancytopenia has been developed on a 54-year old female patient with GBM after concurrently used temozolomide and radiotherapy treatment. It should be kept in mind that this side effect may develop because the risk of morbidity and mortality may be elevated. Therefore, supportive therapies should be started immediately in patients where this toxicity developed.


Keywords: Temozolomide , Glioblastoma multiforme , Pancytopenia

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How to cite this article:

Kubra Bozkurt , Esra Terzı Demırsoy, Esma Turkmen Bekmez, Dıncer Aydın. Temozolamide-Associated Pancytopenia in a Patient with Glioblastoma Multiforme. International Journal of Case Reports, 2019 4:72. DOI: 10.28933/ijcr-2019-03-2106


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