Ototoxicity and neurotoxicity from exposure to a mixture of organic solvents and noise, a case report


Ototoxicity and neurotoxicity from exposure to a mixture of organic solvents and noise, a case report


Rebeca Velasco-Reyna1, Ana Luisa Nayeli Torres-Flores2, Rubén Rojo-Ramírez2, Guadalupe Aguilar-Madrid3, Arturo Torres-Valenzuela4, Cuauhtémoc Arturo Juárez-Pérez4
1Área de Enfermedades de Trabajo, Coordinación de Salud en el Trabajo, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI; 2Coordinación de Evaluación de Salud en el Trabajo, Hospital General de Zona 30 Iztacalco. Instituto Mexicano del Seguro Social; 3Claustro Universitario, Chihuahua Chih. México; 4Unidad de Investigación de Salud en el Trabajo, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI


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Background: Neuropsychological alterations and decreased hearing, are related to organic solvents (OS) exposure; and if noise is present it potentiates the hearing damage.

Aim: to evaluate neuropsychological performance and hearing of a 50 years old worker, occupationally exposed to OS mixtures for 26 years (toluene, ethyl acetate and isopropyl alcohol) and noise > 85 dB (A).

Design of study: Report of a case assessed by Neuropsychological tests, CT and SPECT studies of hearing and clinic-occupational history. Results: He presented, loss between 35 to > 55 dB HL of his hearing in both ears, both in low frequencies (125 Hz-2 kHz) as well as the treble ones (3-8 kHz), in relation to his age. There was an otoacoustic emissions absence at the same frequencies. He showed cerebellar atrophy, cognitive, motor and emotional disorders.

Conclusions: We Integrated diagnosis of: moderate to severe hearing loss, mental and behaviour disorders due to the simultaneous exposure to noise and an OS mixture, mainly toluene. It should fully evaluate workers exposed to noise and OS.


Keywords: Ototoxicity, neurotoxicity, toluene, noise, emissions otoacoustic audiometry.

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How to cite this article:

Rebeca Velasco-Reyna, Ana Luisa Nayeli Torres-Flores, Rubén Rojo-Ramírez, Guadalupe Aguilar-Madrid, Arturo Torres-Valenzuela, Cuauhtémoc Arturo Juárez-Pérez . Ototoxicity and neurotoxicity from exposure to a mixture of organic solvents and noise, a case report . International Journal of Case Reports, 2019 4:89. DOI: 10.28933/ijcr-2019-07-2606


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