Osseous metaplasia in thyroid nodule: A case report and review of literature


Osseous metaplasia in thyroid nodule: A case report and review of literature


Soha Yahya Hejazi1, Nisar Haider Zaidi1, Ahmad Ghanem2, Adel. A. Aljawhari1

1Department of surgery, King Abdulaziz University Hospital POBOX-80215 Jeddah 21589 , Saudi Arabia; 2Department of Pathology, King Abdulaziz University Hospital POBOX-80215 Jeddah 21589 , Saudi Arabia


International-Journal-of-Case-Reports-2d code

Objective: To present a case of osseous metaplasia in thyroid nodule. Introduction: Long standing thyroid nodules undergo changes. Sometimes they degenerate, may lead to hemorrhage or fibrosis and sometimes ectopic bone formation. Case report: 41 years old Yemeni married lady, presented to our surgical clinic with left thyroid nodule for 3 years duration. She had right thyroid lobectomy 6 years ago. She presented with left neck swelling and was taken to OR for thyroidectomy. histopathology came as extensive fibrosis and osseous metaplasia with small remnant of thyroid tissue. Discussion; Most thyroid stay longer with no complications but some undergo calcification or hemorrhage, fibrosis and sometimes osseous metaplasia. It may occur in benign or malignant thyroid swellings.


Keywords: Osseous metaplasia, Thyroid nodule ectopic bone

Free Full-text PDF


How to cite this article:

Soha Yahya Hejazi, Nisar Haider Zaidi, Ahmad Ghanem, Adel. A. Aljawhari.Osseous metaplasia in thyroid nodule: A case report and review of literature . International Journal of Case Reports, 2019 4:97. DOI: 10.28933/ijcr-2019-09-2005


References:

1. Rosai J, Thyroid gland. In: Rosai and Ackerman’s Surgical Pathology. 9th edition. Mosby, New York, NY, p529, 2004.
2. Mortensen JD, Bennett WA, and Woolner LB: Incidence of carcinoma in thyroid glands removed at 1000 consecutive routine necropsies. Surg Forum 5: 659 663, 1955.
3. Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, et al: The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 7: 481 493, 1977.
4. Visonà A, Pea M, Bozzola L, Stracca Pansa V and Meli S: Follicular adenoma of the thyroid gland with extensive chondroid metaplasia. Histopathology 18: 278 279, 1991.
5. Ardito G, Fadda G, Revelli L, Modugno P, Lucci C, Ardito F, et al: Follicular adenoma of the thyroid gland with extensive bone metaplasia. J Exp Clin Cancer Res 20: 443 445, 2001.
6. Gal-Gombos et. Al 2002; Osseous metaplasia of breast : diagnosis with stereotactic core biopsy, The breast journal 8(1):50-52
7. Pontikides N, Botsios D, Kariki E, Vassiliadis K and Krassas GE: Extramedullary hemopoiesis in a thyroid nodule with extensive bone metaplasia and mature bone formation. Thyroid 13: 877 880, 2003.
8. Akbulut S, Yavuz R, Akansu B, Sogutcu N, Arikanoglu Z and Basbug M: Ectopic bone formation and extramedullary hemato¬poiesis in the thyroid gland: report of a case and literature review. Int Surg 96: 260 265, 2011.
9. Hopkins DR, Keles S and Greenspan DS: The bone morpho¬genetic protein 1/Tolloid like metalloproteinases. Matrix Biol 26: 508 523, 2007.
10. Rattenholl A, Pappano WN, Koch M, Keene DR, Kadler KE, Sasaki T, et al: Proteinases of the bone morphogenetic protein 1 family convert procollagen VII to mature anchoring fibril collagen. J Biol Chem 277: 26372 26378, 2002
11. Basbug M, Yavuz R, Dablan M and Akansu B: Extensive osseous metaplasia with mature bone formation of thyroid gland. J Endocrine Met 2: 99-101, 2012..
12. Jacobson RJ, Salo A, Fiallkow PJ: Agnogenic myeloid metaplasia: A clonal proliferation of hematopoietic stem cells with secondary myelofibrosis. Blood 51:189,1978
13. Consorti F, Anello A, Benvenuti C, Boncompagni A, Giovannone G, Moles N, et al. Clinical value of calcifications in thyroid carcinoma and multinodular goiter. Anticancer Res2003;23(3C):3089-92.
14. Khoo ML, Asa SL, Witterick IJ, Freeman JL. Thyroid calcification and its association with thyroid carcinoma. Head Neck 2002;24(7):651-5.
15. Bai Y, Zhou G, Nakamura M, Ozaki T, Mori I, Taniguchi E, et al. Survival impact of psammoma body, stromal calcification,and bone formation in papillary thyroid carcinoma.Mod Pathol 2009;22(7):887-94.
16. Watters DA, Ahuja AT, Evans RM, Chick W, King WW,Metreweli C, et al. Role of ultrasound in the management of thyroid nodules. Am J Surg 1992;164(6):654-7.
17. Murat Basbuga, c, Rldvan Yavuza, Mahmut Dablana, Bulent Akansub Extensive Osseous Metaplasia With Mature Bone Formation of Thyroid GlandJ Endocrinol Metab • 2012;2(2):99-101.
18. 18-N Aurora,I Hashmi, S Misra, N Ayedin :A rare presentation: A case report of osseous metaplasia and mature bone formation in a follicular adenoma of the thyroid. International Journal of Surgery Case Reports.16-37(2017)83–86.
19. Bataille S, Daniel L, Legris T, Vacher-Coponat H, Purgus R, Berland Y, Moal V. Osseous metaplasia in a kidney allograft. Nephrol Dial Transplant. 2010;25(11):3796-3798.
20. Ryosuke KOBAYASHI1)*, Naoaki YAMADA1), Takashi KITAMORI2), Fumiyo KITAMORI2), Kazunari SATO3), Takuya DOI1), Yumi WAKO1), Junko SATO1) and Minoru TSUCHITANI1Follicular Thyroid Carcinoma Characterized by Abundant Stromal Components with Chondroid and Osseous Metaplasia in a Dog J. Vet. Med. Sci. 76(8): 1161–1164, 2014.
21. Tzanakakis GN, Scopa CD, Vezeridis MP, Vagenakis A. Ectopic bone in multinodular goiter. R I Med J. 1989;72(5):171-172.
22. Basbug M, Yavuz R, Dablan M and Akansu B: Extensive osseous metaplasia with mature bone formation of thyroid gland. J Endocrine Met 2: 99-101, 2012.
23. AdrianaHandra-Luca,1 Marie-LaureDumuis-Gimenez,2MounaBendib,1andPanagiotisAnagnostisThyroid Sporadic Goiter with Adult Heterotopic Bone Formation. Case Reports in Endocrinology Volume 2015, Article ID 806864, 6 pages.