Invasive Haemophilus influenzae disease in Northwestern Ontario First Nations communities: Case Series

Invasive Haemophilus influenzae disease in Northwestern Ontario First Nations communities: Case Series

Chelsea J. Kubinec MSci1, Len Kelly MD MClinSci2, Sarah Byce MD, MSci1, Raymond S.W. Tsang MMedSc PhD3, Marina Ulanova MD PhD4

1Medical Student, Northern Ontario School of Medicine, Thunder Bay, Ontario; 2Sioux Lookout Meno Ya Win Health Centre, Sioux Lookout, Ontario; 3Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba; 4Division of Medical Sciences, Northern Ontario School of Medicine, Thunder Bay, Ontario

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We present clinical and microbiological data of 5 pediatric cases of invasive Haemophilus influenzae disease, which occurred over a period of 10 months in the service area of a regional hospital of Northwestern Ontario. Four cases of invasive H. influenzae type a (Hia) disease presented either as meningitis, non-complicated and complicated pneumonia, or soft tissue infection in children between 7 months and 6 years of age. Although the cases were from different communities with no known common exposure, the Hia isolates demonstrated similar phenotypic and genotypic characteristics. One case of invasive disease due to nontypeable H. influenzae (NTHi) presented as chorioamnionitis in an adolescent. The data emphasize the significance of Hia and NTHi as a cause of serious disease in Indigenous communities.

Keywords: Haemophilus influenzae, invasive disease, First Nations communities

This study was supported by the Canadian Immunization Research Network (CIRN).

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Chelsea J. Kubinec, Len Kelly, Sarah Byce, Raymond S.W. Tsang, Marina Ulanova. Invasive Haemophilus influenzae disease in Northwestern Ontario First Nations communities: Case Series . International Journal of Case Reports, 2020 4:140. DOI: 10.28933/ijcr-2020-05-2805


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