Oral Lesion like Mucous Membrane Pemphigoid under Carboplatin-induced Hemolytic Anemia and Pancytopenia as Hypersensitive Reactions in a case with Maxillary Sinus Cancer: A Case Report


Oral Lesion like Mucous Membrane Pemphigoid under Carboplatin-induced Hemolytic Anemia and Pancytopenia as Hypersensitive Reactions in a case with Maxillary Sinus Cancer: A Case Report


Yuki Hokita, DH1,  Kazuyo Mori, DH1,  Taihei Yamaguchi, DDS2*, Takahiko Oho, DDS2

1Section of Oral Hygiene,  Kagoshima University Hospital,  Kagoshima,  Japan; 2Department of Preventive Dentistry,  Research Field in Dentistry,  Medical and Dental Sciences Area,  Kagoshima University,  Kagoshima,  Japan


International-Journal-of-Case-Reports-2d code

Here we report the first case of fatal carboplatin induced immune hemolytic anemia in a patient with head and neck malignant neoplasms followed by onset of multi-organ failure. While carboplatin is an effective agent used to treat many kinds of malignant tumorigenic lesion, a number of reports about allergic side effects are present. A 64-year-old male patient diagnosed as maxillary sinus cancer was treated by radiation therapy associated with weekly intravenous infusions of carboplatin. After five times of carboplatin infusion, white blood cell and platelet counts and hemoglobin value gradually decreased, and reached to almost bottom level. Both direct and indirect coombs tests were negative. Reticulocyte count and the value of platelet-associated IgG were high level, and oral lesion-like mucous membrane pemphigoid appeared on tongue and hard plate. Recognition of the particular oral abnormality in the early stage could allow for correct diagnosis and a potentially effective therapy.


Funding: This study was supported in part by JSPS KAKENHI Grant Number 18K09885.


Keywords: hypersensitivity, carboplatin, pemphigoid, maxillary sinus cancer, chemotherapy


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How to cite this article:

Yuki Hokita, Kazuyo Mori, Taihei Yamaguchi, Takahiko Oho. Oral Lesion like Mucous Membrane Pemphigoid under Carboplatin-induced Hemolytic Anemia and Pancytopenia as Hypersensitive Reactions in a case with Maxillary Sinus Cancer: A Case Report. International Journal of Case Reports, 2020 4:142. DOI: 10.28933/ijcr-2020-05-3005


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