Acute Demyelinating Encephalomyelitis (ADEM) following rabies vaccination

Acute Demyelinating Encephalomyelitis (ADEM) following rabies vaccination

Lucia Cavanagh1*, Adriana M. Strutt2, Paul E. Schulz3

1Department of Psychiatry, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California – Los Angeles, Los Angeles, CA, United States.
2Department of Neurology, Baylor College of Medicine, Houston, TX, United States.
3Department of Neurology, McGovern Medical School of UT Health Houston, Houston, TX, United States.

Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system (CNS). Its diagnosis can be challenging due to having varied clinical presentations, including a range of motor, speech, cognitive, and behavioral changes that can vary in frequency and intensity, and there being no strictly defined diagnostic criteria for it in adults. Here we present a 58-year-old White male who developed ADEM following an uncommon cause (i.e., rabies vaccination), which was difficult to diagnose due to atypical manifestations.

Keywords: Acute disseminated encephalomyelitis (ADEM); rabies; vaccine; parkinsonism; cognitive dysfunction; neuropsychology

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Lucia Cavanagh, Adriana M. Strutt, Paul E. Schulz. Acute Demyelinating Encephalomyelitis (ADEM) following rabies vaccination. International Journal of Case Reports, 2021; 5:206. DOI: 10.28933/ijcr-2021-03-1305


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