Giant gastric carcinosarcoma infiltrating the left hepatic lobe: a case report


Giant gastric carcinosarcoma infiltrating the left hepatic lobe: a case report


Leonardo Vincenti MD1, Cinzia Bizzoca MD1, Salvatore Fedele MD2, Anna Maria Valentini BScD3, Valeria Andriola1, Graziana Arborea MD3

1General Surgery “Ospedaliera”, Policlynics of Bari, Italy; 2Dept of General Surgery, National Institute of Gastroenterology “S. de Bellis”, Research Hospital, CastellanaGrotte (BA), Italy; 3Dept of Pathology, National Institute of Gastroenterology “S. de Bellis”, Research Hospital, Castellana Grotte (BA), Italy


Gastric carcinosarcoma is a rare biphasic tumor that consists of both carcinomatous and sarcomatous components. Clinical presentation and neoplastic markers are not specific for the disease. Moreover, CT scan cannot distinguish among gastric carcinoma, sarcoma or carcinosarcoma, so it is essential to perform histopathological and immunohistochemical analysis on biopsy specimens or resected tissue to ensure a correct diagnosis.
A 72-year-old woman was transferred to our Department from another hospital with a diagnosis of a bleeding tumor localized on the lesser gastric curve, infiltrating the left hepatic lobe.
The mass was treated as a gastric malignant mesenchymal neoplasia (gastro-intestinal stromal tumor versus sarcoma) infiltrating the liver. Owing to the bleeding, no further invasive examinations, such as fine needle aspiration biopsy, were planned. Furthermore, no neoadjuvant chemotherapy could be administered before surgery due to persistent anaemia.
The scheduled surgical procedure was an atypical gastric resection with “en bloc” hepatic resection. This operation included upper polar and lesser curve resection, with tubulization of the stomach along the greater curve, as well as left lateral hepatic sectionectomy.
Histopathological examination and immunohistochemical staining confirmed the diagnosis of gastric carcinosarcoma.
This is first report of gastric carcinosarcoma with local liver infiltration, treated with surgical resection.


Keywords: Gastric Carcinosarcoma; Gastrectomy; Hepatic resection


Free Full-text PDF


How to cite this article:

Leonardo Vincenti, Cinzia Bizzoca, Salvatore Fedele, Anna Maria Valentini, Valeria Andriola, Graziana Arborea. Giant gastric carcinosarcoma infiltrating the left hepatic lobe: a case report. International Journal of Case Reports, 2021, 5:214. DOI: 10.28933/ijcr-2021-03-2606


References:

1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA: A Cancer Journal for Clinicians. 2015;65(2). doi:10.3322/caac.21262
2. CIROCCHI R, TRASTULLI S, DESIDERIO J, et al. Gastric carcinosarcoma: A case report and review of the literature. Oncology Letters. 2012;4(1). doi:10.3892/ol.2012.699
3. Bekki T, Fujikuni N, Tanabe K, et al. The gastric carcinosarcoma with severe venous invasion: a case report. Surgical Case Reports. 2018;4(1). doi:10.1186/s40792-018-0421-8
4. Choi KW, Lee WY, Hong SW, Chang YG, Lee B, Lee HK. Carcinosarcoma of the Stomach: A Case Report. Journal of Gastric Cancer. 2013;13(1). doi:10.5230/jgc.2013.13.1.69
5. Lazaridis II, Lazaridis L-D, Spartalis E, Frountzas M, Schizas D. Gastric carcinosarcoma: a rare clinical entity looking for an identity. JBUON. 2018;23(5):1262-1265.
6. Fujiie M, Yamamoto M, Taguchi K, et al. Gastric carcinosarcoma with rhabdomyosarcomatous differentiation: a case report and review. Surgical Case Reports. 2016;2(1). doi:10.1186/s40792-016-0176-z
7. Selcukbiricik F, Tural D, Senel ET, Dervisoglu S, Serdengecti S. Gastric carcinoma with osteoblastic differentiation. International Journal of Surgery Case Reports. 2012;3(11). doi:10.1016/j.ijscr.2012.07.001
8. Kuroda H, Saito H, Kono Y, et al. Carcinosarcoma of stomach confined to the mucosa. Yonago Acta Medica. 2017;60(4):246-250. doi:10.24563/yam.2017.12.006
9. Li J, Liang P, Zhang D, et al. Primary carcinosarcoma of the liver: imaging features and clinical findings in six cases and a review of the literature. Cancer Imaging. 2018;18(1). doi:10.1186/s40644-018-0141-0
10. Wronski M. Synchronous occurrence of gastrointestinal stromal tumors and other primary gastrointestinal neoplasms. World Journal of Gastroenterology. 2006;12(33). doi:10.3748/wjg.v12.i33.5360
11. Nie L, Zhou X, Peng L, Fu Y, Cheng Y, Huang Q. Histological heterogeneity and distributional difference of gastric carcinosarcoma: Report of 4 cases and literature review. Polish Journal of Pathology. 2018;69(4):366-375. doi:10.5114/pjp.2018.81696
12. Gohongi T. Postsurgical radiation therapy for gastric carcinosarcoma with c-kit expression: A case report. World Journal of Gastroenterology. 2015;21(9). doi:10.3748/wjg.v21.i9.2830
13. Ochiai A, Teramachi K, Kanomata N, Hasebe T, Ishii G, Sugito M. Carcinosarcoma (pure endocrine cell carcinoma with sarcoma components) of the stomach. Pathology International. 2003;53:552-556. doi:10.1046/j.1320-5463.2003.01508.x
14. Liu S-W, Chen G-H, Hsieh P-P. Collision Tumor of the Stomach. Journal of Clinical Gastroenterology. 2002;35(4). doi:10.1097/00004836-200210000-00010
15. Randjelovic T. Carcinosarcoma of the stomach: A case report and review of the literature. World Journal of Gastroenterology. 2007;13(41). doi:10.3748/wjg.v13.i41.5533
16. Carcangiu ML, Steeper T, Zampi G, Rosai J. Anaplastic Thyroid Carcinoma: A Study of 70 Cases. American Journal of Clinical Pathology. 1985;83(2). doi:10.1093/ajcp/83.2.135
17. Tokunaga O, Morimatsu M, Nakashima T. COLLISION TUMOR OF THE STOMACH WITH CARCINO-SARCOMA AND TUBULO-PAPILLARY ADENOCARCINOMA. Pathology International. 1979;29(5). doi:10.1111/j.1440-1827.1979.tb00947.x
18. Kayaselçuk F, Tuncer İ, Toyganözü Y, Bal N, Özgür G. Carcinosarcoma of the stomach. Pathology&OncologyResearch. 2002;8(4). doi:10.1007/BF03036745


Terms of Use/Privacy Policy/ Disclaimer/ Other Policies:
You agree that by using our site, you have read, understood, and agreed to be bound by all of our terms of use/privacy policy/ disclaimer/ other policies (click here for details).



This work and its PDF file(s) are licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.