Therapeutic Plasma Exchange in Postpartum Hemolytic Uremic Syndrome: A Case Report


Therapeutic Plasma Exchange in Postpartum Hemolytic Uremic Syndrome: A Case Report


SIRAT KAUR

Department of ImmunoHematology and Blood Transfusion Dayanand Medical College and Hospital


BACKGROUND AND AIM: Adult, non-infective, haemolytic-uremic syndrome (HUS) although a rare disease in itself, has a high likelihood of occurrence in pregnancy and immediate post partum period. It is an important differential diagnosis in the evaluation of thrombotic microangiopathies. Patients with post-partum HUS display a classical triad of microangiopathic haemolytic anaemia, acute nephropathy and thrombocytopenia.

I hereby present a case of post partum HUS treated with therapeutic plasma exchange (TPE)

MATERIAL AND METHODS: A total of six sessions of TPE were performed daily, three sessions for consecutive days and remaining three sessions were performed on alternate days. All the procedures were carried out with Haemonetics MCS+ exchanging one plasma volume using fresh frozen plasma and saline as replacement fluid. Haemodialysis was started and four sessions were carried out on alternate days.

RESULT: A 37 year old, 85 kg female, G2 P1, underwent emergency LSCS because of foetal distress at 38 weeks of pregnancy. Post surgery she developed decreasing urine output, anuria ensued. Emergency therapeutic plasma exchange was carried out within 24 hours of diagnosis. It could be found that with TPE, patient had improvement in renal function, decrease in LDH levels and increase in platelet count. Patient had sustained remission and discontinuation of haemodialysis.

CONCLUSION: HUS is a disorder with high mortality and long term morbidity, if prompt treatment is not instituted. The decision to intervene with plasma exchange should be based upon the severity of thrombocytopenia, microangiopathic haemolytic anaemia and neurological abnormalities, even if the diagnosis and nomenclature is uncertain. Improved survival after this disorder has been attributed to aggressive treatment with plasma exchange therapy.


Keywords: Therapeutic Plasma Exchange; Postpartum Hemolytic Uremic Syndrome; Case Report


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How to cite this article:

SIRAT KAUR. Therapeutic Plasma Exchange in Postpartum Hemolytic Uremic Syndrome: A Case Report. International Journal of Case Reports, 2021,5:229. DOI: 10.28933/ijcr-2021-07-0309


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