Cardiac Metastatic Involvement in Lung Cancer – Cardiac Metastatic Involvement


Cardiac Metastatic Involvement in Lung Cancer – Cardiac Metastatic Involvement


Miguel Borregón1*, Katherine Martínez2, Alba Ramos1, Irene Ramos1, Beatriz Berzal1, Manuel Mazariegos1, Margarita Díez1, Cristina Gómez1, Ana Belén Rupérez1, Irene Otero1, Ana Karina Santos1, Juan David Cárdenas1, Elia Martínez3

1Medical oncology service. Hospital Virgen de la Salud de Toledo, Spain; 2Medical oncology service. Hospital General de Segovia, Spain; 3Medical oncology service. Hospital Universitario de Fuenlabrada, Spain.


Lung cancer is the second most common solid tumour and the first in mortality worldwide. Important progress has been reached in recent years in this pathology, focusing its treatment on histology, molecular biology and clinical presentation. Cardiac metastatic involvement consists in a severe clinical entity with increasing incidence due to better radiological techniques and longer survival of lung cancer. It requires special care and attention from many specialists. Clinical review about cardiac involvement secondary to lung cancer is provided, focused on its epidemiology, clinical presentation, diagnoses and treatment. Better understanding about cancer natural history is needed to offer the best treatment and care.

Condensed abstract

Cardiac metastatic involvement consists in a severe clinical entity with increasing incidence due to better radiological techniques and longer survival of lung cancer. It requires special care and attention from many specialists. Clinical review about cardiac involvement secondary to lung cancer is provided, focused on its epidemiology, clinical presentation, diagnoses and treatment.

Keywords: Lung cancer, Heart metastases, Malignant pericardial effusion, Cardiac tamponade

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How to cite this article:

Miguel Borregón, Katherine Martínez, Alba Ramos, Irene Ramos , Beatriz Berzal, Manuel Mazariegos, Margarita Díez, Cristina Gómez, Ana Belén Rupérez, Irene Otero, Ana Karina Santos, Juan David Cárdenas, Elia Martínez. CARDIAC METASTATIC INVOLVEMENT IN LUNG CANCER – CARDIAC METASTATIC INVOLVEMENT. International Journal of Case Reports, 2021, 5:252. DOI: 10.28933/ijcr-2021-09-2305


References:

1. Burazor I, Aviel-Ronen S, Imazio M, et al. Meta-static cardiac tumours: from clinical presentation through diagnosis to treatment. BMC Cancer 2018; 18: 202.
2. Meddeb M, Chow RD, Whipps R, et al. The heart as a site of metastasis of benign metastasizing leiomyoma: case report and review of the litera-ture. Case Rep Cardiol 2018; 2018: 7231326.
3. Mercado-Guzman MP, Meléndez-Ramírez G, Castillo-Castellon F, et al. Evaluation of cardiac tumours by multidetector computed tomography and magnetic resonance imaging. Arch Cardiol Mex 2016; 86: 335–49.
4. Nomoto N, Tani T, Konda T, et al. Primary and metastatic cardiac tumours: echocardiographic diagnosis, treatment and prognosis in a 15-years single centre study. J Cardiothorac Surg 2017; 12: 103.
5. Perisano C, Spinelli MS, Graci C, Scaramuzzo L, Marzetti E, Barone C, Fabbriciani C. Soft tissue metastases in lung cancer: a review of the litera-ture. Eur Rev Med Pharmacol Sci. 2012;16(14):1908–14.
6. Scatena C, Comin CE, Lapini A, Raspollini MR. Renal metastasis from pulmonary adenocarci-noma: the pathologist’s approach to an un-common finding: case report and review of the literature. Appl Immunohistochem Mol Morphol. 2013;21(5):460–3.
7. Kovacs KA, Hegedus B, Kenessey I, Timar J. Tumor type-specific and skin region-selective metastasis of human cancers: another example of the “seed and soil” hypothesis. Cancer Metastasis Rev. 2013;32(3–4):493–9.
8. Plaza JA, Perez-Montiel D, Mayerson J, Morrison C, Suster S. Metastases to soft tissue: a review of 118 cases over a 30-year period. Cancer. 2008;112(1): 193–203.
9. Fei-Yu Niu, Qing Zhou, Jin-Ji Yang, Wen-Zhao Zhong, Zhi-Hong Chen, Wei Deng, Yan-Yan He, Hua-Jun Chen, Zhu Zeng, E-E Ke, Ning Zhao, Na Zhang, Hui-Wen Sun, Qiu-Yi Zhang, Zhi Xie, Xu-Chao Zhang and Yi-Long Wu; Distribution and prognosis of uncommon metastases from non-small cell lung cancer; Niu et al. BMC Cancer (2016) 16:149; DOI 10.1186/s12885-016-2169-5.
10. Shosaku A.B.E., Naomi Watanabe, Shigeaki Ogura, Hiroshi Kunikane, Hiroshi Isobe, Etsuro Yamaguchi, Mitsuru Munakata and Yoshikazu Kawakami; Myocardial Metastasis from Primary Lung Cancer: Myocardial Infarction-like ECG Changes and Pathologic Findings; Jpn J Med Vol 30, No 3 (May, June 1991).
11. Butany J., Nair V., Naseemuddin A., Nair G.M., Catton C., Yau T.; Cardiac tumours: diagnosis and management; Lancet Oncology 6:219-228, 2006.
12. Reynen K., Kockeritz U., Strasser R.H.; Metas-tases to the heart; Ann Oncol 2004; 15:375-81.
13. Zakharova VP, Rudenko YeV, Galakhin KA, et al. Cardiac mixomas (morphological aspects). Kyiv: Kniga-plyus; 2003. 142 p.
14. Tsang TS, Seward JB, Barnes ME, Bailey KR, Sinak LJ, Urban LH, et al. Outcomes of primary and secondary treatment of pericardial effusion in patients with malignancy. Mayo Clin Proc. 2000 75(3);248–253. https://doi.org/10.4065/75.3.248.
15. Gornik HL, Gerhard-Herman M, Beckman JA. Abnormal cytology predicts poor prognosis in cancer patients with pericardial effusion. J Clin Oncol.2005(22); 23:5211–5216. https://doi.org/10.1200/JCO. 2005.00.745.
16. Kim SH, Kwak MH, Park S, Kim HJ, Lee HS, Kim MS, et al. Clinical characteristics of malignant pericardial effusion associated with recurrence and survival. Cancer Res Treat.2010; 42 (4):210–216. https:// doi.org/10.4143/crt.2010.42.4.210 PMID: 21253323.
17. Ou SH, Zell JA. Validation study of the proposed IASLC staging revisions of the T4 and M non-small cell lung cancer descriptors using data from 23,583 patients in the California Cancer Registry. J Thorac Oncol.2008; 3(3): 216–227. https://doi.org/10.1097/JTO.0b013e318164545d PMID: 18317063.
18. Kato R, Hayashi H, Chiba Y, Tanaka K, Takeda M, Nakagawa K. Prognostic impact of minimal per-icardial effusion in patients with advanced Non-small-cell Lung Cancer. Clin Lung Cancer. 2017; 18(6): e449–e455. https://doi.org/10.1016/j.cllc.2017.05.011.
19. Hoffmeier A, Sindermann JR, Scheld HH, et al. Cardiac tumours — diagnosis and surgical treatment. Dtsch Arztebl Int 2014; 111: 205–11.
20. Pacini D, Careddu L, Pantaleo A, et al. Primary malignant tumours of the heart: Outcomes of the surgical treatment. Asian Cardiovasc Thorac Ann 2015; 23: 645–51.
21. Liu Y.C.; Ho Y.L., Huang G.T., Chen D.S., Sheu J.C., Chen C.H.; Clinical manifestation and sur-vival of patients with hepatocelular carcinoma and cardiac metastases; J. Gastroenterol Hepatol (2010) 25:150-5.
22. Deetjen A., Conradi G., Mollmann S., Kluge A., Hamm C.W., Dill T; Cardiac metastases of a renal cell adenocarcinoma investigated by cardiac magnetic resonance imaging; Clin Res Cardiol 2006;95:492-5.
23. Cates C.U., Virmani R., Vaughn W.K., Robertson R.M.; Electrocardiographic markers of cardiac metastases; Am. Heart J. 112: 1297, 1986.
24. Chiu-Fan Chen, Min-Hsi Lin, Kuo-An Chu, Wen-Shan Liu, Shih-Hung Hsiao, Ruay-Sheng Lai; Effective cardiac radiotherapy relieved life-threatening heart failure caused by advanced small cell lung cancer with cardiac metastasis: a case report; Journal of thoracic disease, 2018; 10(4): E250-E254.


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