Research Article of International Journal of Hospital Pharmacy
Healthcare professionals’ awareness towards drug-drug interaction in Ayder comprehensive specialized hospital Mekelle, Ethiopia
Betelhem Endal1, Desalegn Getnet2, Desye Gebrie1
1.Pharmacoepidemiology and Social Pharmacy Course and Research Team, School of Pharmacy, College of Health Science, Mekelle University, Mekelle, Ethiopia; 2.Pharmacology and Toxicology Course and Research Team, Department of Pharmacy, Adigrat University, Adigrat, Ethiopia
Background: Healthcare professionals are the most responsible body to identify potential interaction of drugs that are prescribed as well as those that the patient may be self-administering. However, awareness of healthcare professionals towards drug-drug interaction is poor. So to improve patient medication safety, it is important to assess healthcare professionals’ knowledge pertaining to drug-drug interactions and common drug-drug interactions information sources.
Method: Cross-sectional study design was employed. Self-administered questionnaire was prepared to assess healthcare professionals’ knowledge of drug-drug interactions and usual sources of drug-drug interaction information. Participants were asked to classify 10 drug pairs as ‘contraindicated’, ‘can be used with monitoring’, ‘no interaction’ and ‘not sure’. Study was conducted from November 2017 to June 2018. Participants were selected using simple random sampling method. Data were analyzed using statistical software, SPSS for windows version 20. The relationship between knowledge and independent variables (age, sex, profession, work experience, training, familiarity with standard treatment guideline perception and source of information) was assessed using binary logistic regression analysis (Crude and adjusted Odds ratio, 95% confidence interval).
Result: The study was done by enrolling 293 healthcare professionals among whom 46 were Physician, 31 Pharmacist, and 216 Nurses. Over all, healthcare professionals in Ayder Comprehensive Specialized Hospital had low score (24.29%) knowledge of drug-drug interactions. However, among the healthcare professionals pharmacists had good drug-drug interactions knowledge than physicians and nurses with an average score of 32.87%, 21.06% and 18.96% respectively. Drug reference books were the most cited drug-drug interaction information source used by 97 (33.10%) participants. Familiarity to the standard treatment guideline, profession and drug-drug interaction information sources were found to be associated with healthcare professionals’ knowledge of drug-drug interactions (p value <0.005).
Conclusion/recommendation: Healthcare professionals had poor knowledge about drug-drug interactions. So they should be alarmed to increase their knowledge to reduce the adverse clinical outcomes of drug-drug interaction related morbidity and healthcare costs.
Keywords: Drug-drug interaction, Knowledge, Healthcare professionals, Ethiopia
How to cite this article:
Betelhem Endal, Desalegn Getnet, Desye Gebrie.Healthcare professionals’ awareness towards drug-drug interaction in Ayder comprehensive specialized hospital Mekelle, Ethiopia. International Journal of Hospital Pharmacy, 2019,4:32.
1. Drug- drug interaction. Available from: htts://medicaldictonary.com/drug-drug interaction [Accessed date Dec 8/ 2017]
2. Bai, P F. Ongoing Challenges in Drug Interaction Safety: from Exposure to Pharmacogenomics. Drug Metab. Pharmacokinet, 2010; 25 (1): 62–71.
3. Janchawee, B., Wongpoowarak, W., Owatranporn, T. et al. Pharmacoepidemiologic study of potential drug interactions in outpatients of a university hospital in Thailand. J Clin Pharm Therap, 2005; 30 (1): 13–20.
4. Kothari N and Ganguly B. Potential Drug-Drug Interactions among Medications Prescribed to Hypertensive Patients. Journal of clinical and diagnostic research: JCDR. 2014; 8(11).
5. Grizzle AJ, Mahmood MH, Ko Y, et al. Reasons provided by prescribers when overriding drug-drug interaction alerts. Managed Care. 2007; 13(10):573-580.
6. Roblek T, Vaupotic T, Mrhar A, et al. Drug-drug interaction software in clinical practice: a systematic review. European Journal of Clinical Pharmacology. 2015; 71(2):131–142.
7. Ocana-ZuritaMC, Juárez-RojopIE, GenisA, et al. Potential drug-drug interaction in Mexican patients with schizophrenia. Int J Psychiaty Clin Pract. 2016; 20(4):249-53
8. SJ Lubinga and E Uwiduhaye. Potential drug-drug interactions on in-patient medication prescriptions at Mbarara Regional Referral Hospital (MRRH) in western Uganda. Afric Health Sci. 2011; 11(3): 501-02 and 499–507.
9. Feinstein J, Dia D, Zong W, et al. Potential drug-drug interactions in infant, child, and adolescent patients in children’s hospitals. Pediatrics. 2015; 135(1):99-108.
10. Sharma S, ChetriHp and Alam K. A study of potential drug-drug interactions among hospitalized cardiac patient in teaching hospital in western Nepal. Indian J pharmcol. 2014; 46(2):152-6.
11. Nabovati E, Vakili A, Taherzadeh Z, et al. A survey of attitude, practice and knowledge regarding drug-drug interaction among medical residents in Iran. Int J Clin pharm. 2017; 39(3):560-568.
12. Adrienne M Gilligan, Terri L and Warholak; Pharmacy students’ Retention of knowledge of drug-drug interaction. Am J Pharm Educ. 2011; 75(6):110.
13. Ko Y, Malone DC, D’Agostino JV, et al. Potential Determinants of Prescribers’ Drug-Drug Interaction Knowledge. Res Social Adm Pharm. 2008; 4(4):355–366.
14. Moges G. Assessment of physicians’ awareness on drug-drug interaction and common source of information in general hospital of Addis Ababa. Master’s Thesis. Addis Ababa University, 2013. Available from: http://etd.aau.edu.et/bitstream/handle/123456789/1837/Getachew%20Moges.pdf?sequence=1&isAllowed=y
15. Al Hamid A, Aslanpour Z, Aljadhey H, et al. Hospitalization Resulting from Medicine-Related Problems in Adult Patients with Cardiovascular Diseases and Diabetes in the United Kingdom and Saudi Arabia. International journal of environmental research and public health. 2016; 13(5):479.
16. Haji Aghajani M, SistanizadM, Abbasinazari, et al. Potential Drug-drug Interactions in Post-CCU of a Teaching Hospital. Iran J Pharm Res. 2013; 12(1): 243–248.
17. The New Mexico AIDS Education and Training Center. http://www.aidsinfonet.org [Accessed Dec12/2017]
18. Mohamed N. Al-Arifi, Syed Wajiad, et al. Evaluation of knowledge of health care professionals on warfarin interactions with drug and herb medical in central Saudi Arabia. 2016; 32(1):229-233.
19. Gebretsadik Z, Gebrehans M, Getnet D, et al. Assessment of Drug-Drug Interaction in Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia: A Retrospective Study. BioMed Res Int. 2017; https://doi.org/10.1155/2017/9792363
20. Carithers C. A study of Nurse Practitioner Characteristics and Knowledge of Drug-Drug Interactions. University of Arizona; Doctor of Nursing Thesis. 2011. http://www.nursing.arizona.edu/Library/Carithers_Cathrin_Practice_Inquiry.pdf
21. Zheng WY, Richardson LC, Li L, et al. Drug-drug interactions and their harmful effects in hospitalized patient: systemic review and mete-analysis. Eur J Clinpharmacol. 2017.
22. Karahan A, Isik AS, Kav S,et al. A. Oncology nurses’ awareness of drug interactions. Asia Pac OncolMurs.2015; 2(4):271-275.
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