Healthcare professionals’ awareness towards drug-drug interaction in Ayder comprehensive specialized hospital Mekelle, Ethiopia


Healthcare professionals’ awareness towards drug-drug interaction in Ayder comprehensive specialized hospital Mekelle, Ethiopia


Betelhem Endal1, Desalegn Getnet2, Desye Gebrie1

1.Pharmacoepidemiology and Social Pharmacy Course and Research Team, School of Pharmacy, College of Health Science, Mekelle University, Mekelle, Ethiopia; 2.Pharmacology and Toxicology Course and Research Team, Department of Pharmacy, Adigrat University, Adigrat, Ethiopia


 International Journal of Hospital Pharmacy

Background: Healthcare professionals are the most responsible body to identify potential interaction of drugs that are prescribed as well as those that the patient may be self-administering. However, awareness of healthcare professionals towards drug-drug interaction is poor. So to improve patient medication safety, it is important to assess healthcare professionals’ knowledge pertaining to drug-drug interactions and common drug-drug interactions information sources.
Method: Cross-sectional study design was employed. Self-administered questionnaire was prepared to assess healthcare professionals’ knowledge of drug-drug interactions and usual sources of drug-drug interaction information. Participants were asked to classify 10 drug pairs as ‘contraindicated’, ‘can be used with monitoring’, ‘no interaction’ and ‘not sure’. Study was conducted from November 2017 to June 2018. Participants were selected using simple random sampling method. Data were analyzed using statistical software, SPSS for windows version 20. The relationship between knowledge and independent variables (age, sex, profession, work experience, training, familiarity with standard treatment guideline perception and source of information) was assessed using binary logistic regression analysis (Crude and adjusted Odds ratio, 95% confidence interval).
Result: The study was done by enrolling 293 healthcare professionals among whom 46 were Physician, 31 Pharmacist, and 216 Nurses. Over all, healthcare professionals in Ayder Comprehensive Specialized Hospital had low score (24.29%) knowledge of drug-drug interactions. However, among the healthcare professionals pharmacists had good drug-drug interactions knowledge than physicians and nurses with an average score of 32.87%, 21.06% and 18.96% respectively. Drug reference books were the most cited drug-drug interaction information source used by 97 (33.10%) participants. Familiarity to the standard treatment guideline, profession and drug-drug interaction information sources were found to be associated with healthcare professionals’ knowledge of drug-drug interactions (p value <0.005).
Conclusion/recommendation: Healthcare professionals had poor knowledge about drug-drug interactions. So they should be alarmed to increase their knowledge to reduce the adverse clinical outcomes of drug-drug interaction related morbidity and healthcare costs.


Keywords: Drug-drug interaction, Knowledge, Healthcare professionals, Ethiopia


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How to cite this article:
Betelhem Endal, Desalegn Getnet, Desye Gebrie.Healthcare professionals’ awareness towards drug-drug interaction in Ayder comprehensive specialized hospital Mekelle, Ethiopia. International Journal of Hospital Pharmacy, 2019,4:32.


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