Nimesulide-induced Fixed Drug Eruption


Nimesulide-induced Fixed Drug Eruption


T.V.Harsha Varun and R.E.Ugandhar

Santhiram College of Pharmacy, Nandyal, Kurnool Dt, Andhra Pradesh


 International Journal of Hospital Pharmacy

Nimesulide is a cyclooxygenase (COX) inhibitor with a high degree of selectivity to COX-2. Nimesulide is a nonsteroidal anti-inflammatory agent with antipyretic and analgesic properties. It is being commonly prescribed in India.[1] Some of the side effects reported with its use are Pruritus, urticaria, purpura, maculopapular rash and localized toxic pustuloderma.[2],[3] Due to severe hepatotoxicity and hemolytic anemia associated with its use, Nimesulide is likely to be withdrawn from the market in many countries.
Case report: The authors report a case of a patient with a history of antihistamine hypersensitivity that developed a bullous form of pigmented fixed drug eruption after Nimesulide. Patch tests performed on residual skin lesion were positive to Nimesulide, confirming that this was the culprit drug.


Keywords: Drug eruption, Fixed drug eruption, Lesion patch testing, Nimesulide, Nonsteroidal anti-inflammatory drugs


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How to cite this article:
T.V.Harsha Varun and R.E.Ugandhar,Nimesulide-induced Fixed Drug Eruption.International Journal of Hospital Pharmacy, 2020, 5:34


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