Research Article of International Journal of Hospital Pharmacy
Nimesulide-induced Fixed Drug Eruption
T.V.Harsha Varun and R.E.Ugandhar
Santhiram College of Pharmacy, Nandyal, Kurnool Dt, Andhra Pradesh
Nimesulide is a cyclooxygenase (COX) inhibitor with a high degree of selectivity to COX-2. Nimesulide is a nonsteroidal anti-inflammatory agent with antipyretic and analgesic properties. It is being commonly prescribed in India. Some of the side effects reported with its use are Pruritus, urticaria, purpura, maculopapular rash and localized toxic pustuloderma., Due to severe hepatotoxicity and hemolytic anemia associated with its use, Nimesulide is likely to be withdrawn from the market in many countries.
Case report: The authors report a case of a patient with a history of antihistamine hypersensitivity that developed a bullous form of pigmented fixed drug eruption after Nimesulide. Patch tests performed on residual skin lesion were positive to Nimesulide, confirming that this was the culprit drug.
Keywords: Drug eruption, Fixed drug eruption, Lesion patch testing, Nimesulide, Nonsteroidal anti-inflammatory drugs
How to cite this article:
T.V.Harsha Varun and R.E.Ugandhar,Nimesulide-induced Fixed Drug Eruption.International Journal of Hospital Pharmacy, 2020, 5:34
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