Research Article of International Journal of Hospital Pharmacy
Nimesulide-induced Fixed Drug Eruption
T.V.Harsha Varun and R.E.Ugandhar
Santhiram College of Pharmacy, Nandyal, Kurnool Dt, Andhra Pradesh
Nimesulide is a cyclooxygenase (COX) inhibitor with a high degree of selectivity to COX-2. Nimesulide is a nonsteroidal anti-inflammatory agent with antipyretic and analgesic properties. It is being commonly prescribed in India. Some of the side effects reported with its use are Pruritus, urticaria, purpura, maculopapular rash and localized toxic pustuloderma., Due to severe hepatotoxicity and hemolytic anemia associated with its use, Nimesulide is likely to be withdrawn from the market in many countries.
Case report: The authors report a case of a patient with a history of antihistamine hypersensitivity that developed a bullous form of pigmented fixed drug eruption after Nimesulide. Patch tests performed on residual skin lesion were positive to Nimesulide, confirming that this was the culprit drug.
Keywords: Drug eruption, Fixed drug eruption, Lesion patch testing, Nimesulide, Nonsteroidal anti-inflammatory drugs
How to cite this article:
T.V.Harsha Varun and R.E.Ugandhar,Nimesulide-induced Fixed Drug Eruption.International Journal of Hospital Pharmacy, 2020, 5:34
1. Kanwar AJ, Kaur S, Thami GP. Nimesulide induced purpura. Dermatolo-gy 2000;201:326.
2. Lateo S, Boffa MJ. Localised toxic pustuloderma associated with nimesu-lide therapy confirmed by patch testing. Br J Dermatol 2002;147:624-5.
3. Saha K. Use of nimesulide in Indian children must be stopped. BMJ 2003;326:713.
5. Ayala F, NinoM,Ayala F, Balato N. Bullous fixed drug eruption induced byNIMUSU-LIDE: of a case. Dermatitis 2006;17:160.
6. Naranjo CA,Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reac-tions. Clin Pharmacol Ther 1981;30:239-45.
7. Hern S, Harman K, Clement M, Black MM. Bullous fixed drug eruption due to nimusulide with an unusual immunofluorescence pattern. Br J Dermatol 1998;139:1129-31.
8. Sanmukhani J, Shah V, Baxi S, Tripathi C. Fixed drug eruption with ornidazole having cross-sensitivity to secnidazole but not to other nitro-imidazole compounds: A case re-port. Br J Clin Pharmacol2010;69:703-4.
9. Shiohara T, Mizukawa Y. Fixed drug eruption: A disease mediated by self-inflicted re-sponses of intraepidermalTcells.EurJDermatol2007;17:201-8.
10. Shiohara T. Fixed drug eruption: Pathogenesis and diagnostic tests. Curr Opin Allergy Clin Immunol2009;9:316-21.
This work and its PDF file(s) are licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.