Review Article of International Journal of Aging Research
Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and Animals
Ian James Martins
aCentre of Excellence in Alzheimer’s Disease Research and Care, Sarich Neuroscience Research Institute, Edith Cowan University, Verdun Street, Nedlands, 6009, Western Australia, Australia; bSchool of Psychiatry and Clinical Neurosciences, The University of Western Australia, Nedlands, 6009; cMcCusker Alzheimer’s Research Foundation, Hollywood Medical Centre, 85 Monash Avenue, Suite 22, Nedlands, 6009, Australia
The process of aging is determined by various genetic and environmental factors. Aging is associated with increased oxidative stress that alters cellular chromatin structure, DNA methylation with histone modifications. These epigenetic alterations lead to nuclear changes associated with mitochondrial apoptosis that is a major defect in the global chronic disease epidemic (1). The variability in longevity between individuals in different communities implicate various nutritional and environmental factors involved in transcriptional dysregulation that lead to cell damage that accumulates with age and contributes to mitophagy, insulin resistance and programmed cell death. The absence or malfunction of a gene (2) necessary for transcriptional regulation of gene expression, DNA repair and telomere maintenance in neurons has become essential with relevance to neurodegeneration that determines aging and lifespan.
Keywords: longevity; species; appetite; immune system; human; mitophagy; animals; neurodegneration; Sirtuin 1; nutritional therapy
How to cite this article:
Ian James Martins. Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and AnimalsInternational Journal of Aging Research, 2018, 1:6. DOI:10.28933/ijoar-2018-05-1101
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2. Sandra Rodríguez-Rodero, Juan Luis Fernández-Morera, Edelmiro Menéndez-Torre, Vincenzo Calvanese, Agustín F. Fernández, Mario F. Fraga. Aging Genetics and Aging. Aging and Disease. 2011;2(3):186-195.
3. Giuseppe Passarino, Francesco De Rango, Alberto Montesanto. Human longevity: Genetics or Lifestyle? It takes two to tango. Immunity and Ageing. 2016;13:(12):1-6.
4. Nir Barzilai, Alan R. Shuldiner. Searching for Human Longevity Genes: The Future History of Gerontology in the Post-genomic Era. Journal of Gerontology, 2001;56A(2):M83–M87.
5. Michal Jazwinski. Longevity, Genes, and Aging. Science. 1996;27(5271):54-59.
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