Is Propanediol a safer molecule than some other glycols in personal care and anti-aging biocosmeceutical products?

Is Propanediol a safer molecule than some other glycols in personal care and anti-aging biocosmeceutical products?

Pierre A. Guertin

Full professor, Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, Quebec City, QC, Canada; Laval University Medical Center, Quebec City, QC, Canada, G1V4G2

international journal of aging research

Propanediol (1,3-propanediol) is an ingredient increasingly used by the industry for electronic cigarettes, personal care creams and anti-aging serums among many other products. For some skin care purposes, it is used to enhance the transdermal absorption of other ingredients (e.g., the actives) enabling moisturizing effects and skin smoothness to be improved. Propanediol may be derived from corn although synthetic forms also exist. It is a chemical similar to other glycols such as propylene glycol (1,2-propanediol) but generally believed to be safer. This short communication reveals in fact that only limited scientific evidence of safety is available. Preliminary signs of toxicity have been found following administration of propanediol in humans although its dose-dependent toxicity and long-term side effects on health have not been significantly explored. Consequently, as of today, skin care and anti-aging products for elderly, a vulnerable population, should not automatically be considered as safe. Those comprising 1,3-propanediol should probably be used with caution until scientifically-proven safety data for the intended purposes are obtained by independent scientists.

Keywords:glycols, 1,3- propanediol, dermatology, anti-aging, organic products, elderly, safety, toxicity

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How to cite this article:
Pierre A. Guertin. Is Propanediol a safer molecule than some other glycols in personal care and anti-aging biocosmeceutical products? International Journal of Aging Research, 2018, 1:23. DOI: 10.28933/ijoar-2018-11-1508


1. Brooksand DE, Wallace KL. Acute propylene glycol ingestion. J. Toxicol. Clin. Toxicol. 2002; 40: 513-516.
2. deRoux SJ, Marker E, Stajic M. Fatalities by ingestion of propyleneglycol. J.Forensic Sci.2005; 50: 939-941.
3. Van de Wiele B, Rubinstein E, Peacock W, Martin N. Propylene glycol toxicity caused by prolonged infusion of eto- midate. J. Neurosurg. Anesthesiol. 1995; 7: 259-262.
4. Wilson KC, Reardon C, Farber HW. Propylene glycol toxicity in a patient receiving intravenous diazepam. N. Engl. J. 2000; A4ed.343:815.
5. Wilson KC, Reardon C, Theodore AC, Farber HW.Propy lene glycol toxicity: a severe iatrogenic illness in ICU patients receiving IV benzodiazepines: a case series and prospective, observational pilot study. Chest. 2005; 128: 1674-1681.
7. Biebl H. Microbial production of 1,3-propanediol. Applied Microbiology and Biotechnology. 1999; 52f : 289-297.
8. Biddy MJ et al., Chemicals from Biomass: A Market Assessment of Bioproducts with Near-Term Potential. Technical Report. 2016.
9. Leigh A. Belcher, Carl F. Muska, Joseph W. DeSalvo. DuPont Evaluating 1,3-Propanediol for Potential Skin Effects. 2013; May 1.
10. Scott RS Frame SR, Ross PE, Loveless SE, Kennedy GL.Inhalation toxicity of 1,3-propanediol in the rat. Inhal. Toxicol. 2005; 17: 487-93.
11. Lewis, R.J. Sr. (ed) Sax’s Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 3061.
12. Holman NW Jr, Mundy RL, Teague RS. Toxicology and Applied Pharmacology. Vol. 49, Pg. 385, 1979.
13. Garg U., Frazee CC 3rd, Kiscoan M, Scott D, Peterson B, Cathcart D. A fatality involving 1,3-propanediol and its implications in measurement of other glycols. J Anal Toxicol. 2008; 32 : 324-6.
14. Bertrand P, Bonnarme V, Piccirilli A, Ayrault P, Lemée L, Frapper G, Pourchez J. Physical and chemical assessment of 1,3 Propanediol as a potential substitute of propylene glycol in refill liquid for electronic cigarettes. Sci Rep. 2018; 8: 10702.

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