Review Article of International Journal of Aging Research
New Approacher in the Development of Alzheimer’s Disease Modifying Drugs
Pedro César de Souza1*, Emmilli Emmanuelle Souza Lins Lima de Carvalho1, Patrícia Maria da Silva Neri Cruz2
1 University Center Mauricio de Nassau, Recife, PE, Brasil; 2Federal University of Pernambuco, Recife, PE, Brasil.
Introduction: Alzheimer’s disease is a more common neurodegenerative disease, affecting 25 million people worldwide, or accounting for about 60 to 70% of all dementia cases. There is currently no exact mechanism to explain the pathophysiology of Alzheimer’s disease, however, cascading metabolic amyloid and post-translational review of tau protein are used as major hypotheses.
Objective: To demonstrate in the literature new approaches in the development of Alzheimer’s disease modifiers.
Methodology: For the accomplishment of this study made in the bibliographical survey of scientific literature and respect to the approached subject, in the databases PUBMED, ScienceDirect, Scielo and Scopus.
Results: Alzheimer’s disease-modifying drugs are not yet available, but many patients may, however, develop phase III clinical trials and are intended to modify as pathological stages leading to the disease. As disease-modifying therapies under study, these changes also affect Aβ and tau protein and also cause inflammation and oxidative damage. The results obtained in the clinical trials performed were positive and promising and are still under study. The results show that there is still a long way to go in the development of Alzheimer’s disease modifying drugs.
Conclusion: The results demonstrated that there is still a long way to go in the development of Alzheimer’s disease modifying drugs, but nevertheless levels at the research level should be continued in order to improve the pathophysiology of the disease and find an effective treatment for this disease the same.
Keywords: Alzheimer’s disease, β-amyloid, Tau hyperphosphorylation, Neurodegeneration
How to cite this article:
Pedro César de Souza, Emmilli Emmanuelle Souza Lins Lima de Carvalho, Patrícia Maria da Silva Neri Cruz. NEW APPROACHER IN THE DEVELOPMENT OF ALZHEIMER’S DISEASE MODIFYING DRUGS. International Journal of Aging Research, 2021, 4:88. DOI: 10.28933/ijoar-2021-07-2005
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