Review Article of International Journal of Aging Research
COVID-19 AND AGEING-RELATED EVENTS
Pedro Henrique Destro1, Geraldo Medeiros Junior2, Joyce Moreira Camargo3, Alphonse Laya4, Valquiria Bueno5*
1Undergraduate Student of Biomedicine, UNIFESP Federal University of São Paulo; 2Undergraduate Student of Biomedicine, UNIP Paulista University; 3Master Student at Department of Microbiology, Parasitology and Immunology, UNIFESP Federal University of São Paulo; 4Post doctor at Department of Microbiology, Parasitology and Immunology, UNIFESP Federal University of São Paulo; 5Associate Professor at Department of Microbiology, Parasitology and Immunology, UNIFESP Federal University of São Paulo.
The first report of patients with the SARS-CoV-2 was in Wuhan on December 2019. In few months the virus was disseminated around the world and has caused millions of deaths. A striking and recurrent finding was the more severe disease and increased numbers of fatal cases in old adults. Vaccines were developed in a record period of time and since then a massive program of vaccination has been installed in several countries. Nevertheless, the decrease in the levels of specific antibody after six months of the first dose in young adults and the reports of fatal cases in vaccinated older patients have suggested that a 3rd dose of vaccine is required. From the first report until now it has been clear that the immune system plays an important role in the disease development and patient outcome. Our group showed recently that healthy old individuals present changes in the immune system that have been reported as immunosenescence and inflammageing. Therefore, our aim was to correlate the findings obtained in healthy old adults with cases of COVID-19 from literature in order to identify possible common factors. The further understanding of how the changes occurring in the immune system during the ageing process can affect the response to SARS-CoV-2 virus could contribute for the development of vaccines or more specific therapies to the aged population.
Keywords: SARS-CoV-2, COVID-19, Ageing, Immunosenescence, Inflammageing
How to cite this article:
Pedro Henrique Destro, Geraldo Medeiros Junior, Joyce Moreira Camargo, Alphonse Laya, Valquiria Bueno. COVID-19 AND AGEING-RELATED EVENTS. International Journal of Aging Research, 2021, 4:91. DOI: 10.28933/ijoar-2021-09-2605
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