MAOA Levels as a Potential Biological Mechanism in Aggression: A Critical Review

MAOA Levels as a Potential Biological Mechanism in Aggression: A Critical Review

Kelly J. Walk, Suchika Siotia

Fielding Graduate University

Across cultures and throughout time, human aggression has been conceptualized in various ways. The monoamine oxidase A (MAOA) gene on the X chromosome (Grimsby et al., 1990) has been implicated in aggression from research originating in the 1990s (Cases et al., 1995; Shih & Thompson, 1999). Researchers have sought to create predictive models of aggression, and throughout decades of research have used several different tools to measure the construct such as the Buss-Perry Aggression Questionnaire and the Conners’ Teachers Rating Scale. This work will analyze and synthesize current scholarly research; a critical review of this impactful line of inquiry will also be provided.

Keywords: monoamine oxidase A (MAOA), aggression

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How to cite this article:

Kelly J. Walk, Suchika Siotia. MAOA Levels as a Potential Biological Mechanism in Aggression: A Critical Review. International Journal of Psychological Research and Reviews, 2023, 6:71. DOI: 10.28933/ijprr-2023-05-3007kws

References

1. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text rev.).
2. Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H., & van Oost, B. A. (1993). Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. American Association for the Advancement of Science, 262 (5133), 578-580. https://doi.org/10.1126/science.8211186
3. Carrel, L., & Willard, H. F. (2005). X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature, 434, 400–404.
4. Cases, O., Seif, I., Grimsby, J., Gaspar, P., & al, et. (1995). Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science, 268(5218), 1763.
5. Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002). Role of genotype in the cycle of violence in maltreated children. Science: American Association for the Advancement of Science, 297(5582), 851-854.
6. Cavanagh, M., Quinn, D., Duncan, D., Graham, T., & Balbuena, L. (2017). Oppositional defiant disorder is better conceptualized as a disorder of emotional regulation. Journal of Attention Disorders, 21(5), 381–389. https://doi-org.fgul.idm.oclc.org/10.1177/1087054713520221
7. Chester, D. S., DeWall, C. N., Derefinko, K. J., Estus, S., Peters, J. R., Lynam, D. R., & Jiang, Y. (2015). Monoamine oxidase A (MAOA) genotype predicts greater aggression through impulsive reactivity to negative affect. Behavioural Brain Research, 283, 97–101. https://doi.org/10.1016/j.bbr.2015.01.034
8. Coccaro, E. F., & Lee, R. (2010). Cerebrospinal fluid 5-hydroxyindolacetic acid and homovanillic acid: Reciprocal relationships with impulsive aggression in human subjects. Journal of Neural Transmission, 117(2), 241–248. https://doi.org/10.1007/s00702-009-0359-x
9. Flanigan, M. E., & Russo, S. J. (2019). Recent advances in the study of aggression. Neuropsychopharmacology, 44(2), 241–244. https://doi.org/10.1038/s41386-018-0226-2
10. Frau, R., Pardu, A., Godar, S., Bini, V., & Bortolato, M. (2022). Combined Antagonism of 5-HT2 and NMDA receptors reduces the aggression of monoamine oxidase A knockout mice. Pharmaceuticals, 15(2), 213. https://doi.org/10.3390/ph15020213
11. Freudenberg, F., Carreño Gutierrez, H., Post, A. M., Reif, A., & Norton, W. H. J. (2016). Aggression in non-human vertebrates: Genetic mechanisms and molecular pathways. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 171(5), 603–640. https://doi.org/10.1002/ajmg.b.32358
12. Gomez, R. (2017). Factor structure of parent and teacher ratings of the ODD symptoms for Malaysian primary school children. Asian Journal of Psychiatry, 25, 22–26. https://doi.org/10.1016/j.ajp.2016.10.013
13. Grimsby, J., Lan, N. C., Neve, R., Chen, K., & Shih, J. C. (1990). Tissue distribution of human monoamine oxidase A and B mRNA. Journal of Neurochemistry, 55, 1166–1169.
14. Han, Y. K. (2008). The relation of psychological variables to relational aggression in early adolescence. Unpublished master’s thesis, Ajou University, Suwon, Korea.
15. Holz, N., Boecker, R., Buchmann, A. F., Blomeyer, D., Baumeister, S., Hohmann, S.,Jennen-Steinmetz, C., Wolf, I., Rietschel, M., Witt, S. H., Plichta, M., Meyer-Lindenberg, A., Schmidt, M. H., Esser, G., & Banaschewski, T., Brandeis, D., & Laucht, M. (2016). Evidence for a sex-dependent MAOA × childhood stress interaction in the neural circuitry of aggression. Cerebral Cortex, 26(3), 904-914.
16. Huang Y., Cate, S. P., Battistuzzi, C., Oquendo, M. A., Brent, D., & Mann, J.J. (2004). An association between a functional polymorphism in the monoamine oxidase A gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology, 29(8):1498–505.
17. Im, S., Jeong, J., Jin, G., Yeom, J., Jekal, J., Lee, S., Cho, J. A., Lee, S., Lee, Y., Kim, D.-H., Bae, M., Heo, J., Moon, C., & Lee, C.-H. (2019). MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli. Scientific Reports, 9(1), 2680. https://doi.org/10.1038/s41598-019-39103-7
18. Iofrida, C., Palumbo, S.,, & Pellegrini, S., (2014). Molecular genetics and antisocial behavior: Where do we stand? Experimental Biology and Medicine, 239(11):1514–23.
19. Jeong, D. (1995). A buffering effects of social support on children’s school stress and maladjustments. Department of Education Graduate School Korea University.
20. Khosravian, M., Nikpour, P., Emadi-Baygi, M., Soleimanpour, A., & Moghadam, F. Y. (2020). Association analysis of monoamine oxidase-A gene promoter polymorphism (MAOA uVNTR) for antisocial behavior: Absence of the counting number repeats in central Iran. Archives of Neuroscience, 7(4), Article 4. https://doi.org/10.5812/ans.102247
21. Kunugi, H., Ishida, S., Kato, T., Tatsumi, M., Sakai, T., Hattori, M., Hirose, T., & Nanko, S. (1999). A functional polymorphism in the promoter region of monoamine oxidase A gene and mood disorders. Molecular Psychiatry, 4(4), 393-395. https://doi.org/10.1038/sj.mp.4000558
22. Ma, R., Gan, G., Zhang, J., Ming, Q., Jiang, Y., Gao, Y., Wang, X., & Yao, S. (2018). MAOA genotype modulates default mode network deactivation during inhibitory control. Biological Psychology, 138, 27–34. https://doi.org/10.1016/j.biopsycho.2018.08.006
23. Mentis, A.-F. A., Dardiotis, E., Katsouni, E., & Chrousos, G. P. (2021). From warrior genes to translational solutions: Novel insights into monoamine oxidases (MAOs) and aggression. Translational Psychiatry, 11(1), 130. https://doi.org/10.1038/s41398-021-01257-2
24. Meyer-Lindenberg, A., Buckholtz, J. W., Kolachana, B., Hariri, A. R., Pezawas, L., Blasi, G., Wabnitz, A., Honea, R., Verchinski, B., Callicott, J., Egan, M., Mattay, V., & Weinberger, D. (2006). Neural mechanisms of genetic risk for impulsivity and violence in humans. Proceedings of the National Academy of Sciences of the United States of America, 103, 6269–6274.
25. No, A. N. (1983). The effects of assertive training on the reduction of aggression and anxiety in juvenile delinquents [master’s thesis]. Seoul: Seoul National University, 1-87.
26. Pai, C., Chou, S. & Huang, F. (2007). Assessment of the role of a functional VNTR polymorphism in MAOA gene promoter: a preliminary study. Forensic Science Journal, 6, 37–43.
27. Park, T. W., Park, Y. H., Kwon, H. J., & Lim, M. H. (2013). Association between TPH2 gene polymorphisms and attention deficit hyperactivity disorder in Korean children. Genetic Testing and Molecular Biomarkers, 17(4), 301–306. https://doi.org/10.1089/gtmb.2012.0376
28. Parrott, D. J., & Giancola, P. R. (2007). Addressing “The criterion problem” in the assessment of aggressive behavior: Development of a new taxonomic system. Aggression and Violent Behavior, 12(3), 280-299. https://doi.org/10.1016/j.avb.2006.08.002
29. Passamonti, L., Cerasa, A., Gioia, M. C., Magariello, A., Muglia, M., Quattrone, A., & Fera, F. (2008). Genetically dependent modulation of serotonergic inactivation in the human prefrontal cortex. Neuroimage, 40(3), 1264–1273.
30. Passamonti, L., Fera, F., Magariello, A., Cerasa, A., Gioia, M. C., Muglia, M., et al. (2006). Monoamine oxidase–A genetic variations influence brain activity associated with inhibitory control: New insight into the neural correlates of impulsivity. Biological Psychiatry, 59, 334–340.
31. Pawliczek, C. M., Derntl, B., Kellermann, T., Kohn, N., Gur, R. C., & Habel, U. (2013). Inhibitory control and trait aggression: Neural and behavioral insights using the emotional stop signal task. Neuroimage, 79, 264-274.
32. Prichard, Z. M., Jorm, A. F., Mackinnon, A., & Easteal, S. (2007). Association analysis of 15 polymorphisms within 10 candidate genes for antisocial behavioural traits. Psychiatric genetics, 17(5), 299-303.
33. Riley, M., Ahmed, S., & Locke, A. (2016). Common questions about oppositional defiant disorder. American Family Physician, 93(7), 586–591
34. Rosell, D. R., & Siever, L. J. (2015). The neurobiology of aggression and violence. CNS Spectrums, 20(3), 254–279. https://doi.org/10.1017/S109285291500019X
35. Sabol, S. Z., Hu, S., & Hamer, D. (1998). A functional polymorphism in the monoamine oxidase A gene promoter. Human Genetics, 103, 273–279.
36. Schlüter, T., Winz, O., Henkel, K., Eggermann, T., Mohammadkhani-Shali, S., Dietrich, C., Heinzel, A., Decker, M., Cumming, P., Zerres, K., Piel, M., Mottaghy, F., & Vernaleken, I. (2016). MAOA-VNTR polymorphism modulates context-dependent dopamine release and aggressive behavior in males. NeuroImage, 125, 378-385. doi:https://doi-org.fgul.idm.oclc.org/10.1016/j.neuroimage.2015.10.031
37. Seo, D., Patrick, C. J., & Kennealy, P. J. (2008). Role of serotonin and dopamine system interactions in the neurobiology of impulsive aggression and its comorbidity with other clinical disorders. Aggression and Violent Behavior, 13, 383–395.
38. Shih, J. C., & Thompson, R. F. (1999). Monoamine oxidase in neuropsychiatry and behavior. American Journal of Human Genetics, 65(3), 593-598. https://doi.org/10.1086/302562
39. Siegel, J. S., Power, J. D., Dubis, J. W., Vogel, A. C., Church, J. A., Schlaggar, B. L., et al. (2014). Statistical improvements in functional magnetic resonance imaging analyses produced by censoring high-motion data points. Human Brain Mapping, 35, 1981–1996.
40. Siever, L. J. (2008). Neurobiology of aggression and violence. The American Journal of Psychiatry, 165, 429–442.
41. Tiihonen, J., Rautiainen, M. .R, Ollila, H. M., Repo-Tiihonen, E., Virkkunen, M., Palotie, A., Pietiilinen, O., Kristiansson, K., Joukamaa, M. , Lauerma, H., Saarela, J., Tyni, S., Vartiainen, H., Paananen, J., Goldman, D. & Paunio, T. (2015). Genetic background of extreme violent behavior. Molecular Psychiatry, 20(6):786.
42. Utendale, W. T., Nuselovici, J., Saint‐Pierre, A. B., Hubert, M., Chochol, C., & Hastings, P. D. (2014). Associations between inhibitory control, respiratory sinus arrhythmia, and externalizing problems in early childhood. Developmental Psychobiology, 56(4), 686-699.
43. Wang, C.-H., Ning, Q.-F., Liu, C., Lv, T.-T., Cong, E.-Z., Gu, J.-Y., Zhang, Y.-L., Nie, H.-Y., Zhang, X.-L., Li, Y., Zhang, X.-Y., & Su, L.-Y. (2018). Associations of serotonin transporter gene promoter polymorphisms and monoamine oxidase A gene polymorphisms with oppositional defiant disorder in a Chinese Han population. Behavioral and Brain Functions, 14(1), 15. https://doi.org/10.1186/s12993-018-0147-6
44. Widom, C. S., & Brzustowicz, L. M. (2006). MAOA and the “cycle of violence:” Childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biological psychiatry, 60(7), 684-689.
45. Williams, L. M., Gatt, J. M., Kuan, S. A., Dobson-Stone, C., Palmer, D. M., Paul, R. H., Song, L., Costa, P. T., Schofield, P. R., Gordon, E. (2009). A polymorphism of the MAOA gene is associated with emotional brain markers and personality traits on an antisocial index. Neuropsychopharmacology (7):1797.
46. Yang, W. (2007). The study of reliability and validity of the aggression questionnaire (revised edition). Applied Psychology. Guangzhou, Guangdong: Jinan University.
47. Zhang, Y., Ming, Q., Wang, X., & Yao, S. (2016). The interactive effect of the MAOA-VNTR genotype and childhood abuse on aggressive behaviors in Chinese male adolescents. Psychiatric Genetics, 26(3), 117–123. https://doi.org/10.1097/YPG.0000000000000125