Peripheral Neuropathy Impacts Gait Motor Components in Hispanic-Latinx living with HIV

Martín G. Rosario PT, PhD, CSFI, ATRIC1*, Leah Jamison, PT, DPT1, Gabriel Gines BS, MPH, CPT, CSFI2

1Texas Woman’s University, Physical Therapy Program, Dallas Campus; Texas; 2Sara Alert, Airport Surveillance System, Department of Health, Puerto Rico.

HIV can cause numerous health-related complications that can lead to disabilities and affect the quality of life. Some problems added with HIV, like peripheral neuropathy (PN), may develop additional impediments in this population.

Purpose: This study investigated PN’s impact on the cardio-motor profile of Hispanic Latino living with HIV.

Methods: A submaximal cardiovascular test (Ross test) was conducted to obtain the study’s cardiomotor results. Cardiomotor data were compiled from records of members enrolled at La Perla de Gran Precio Community Centre on HIV in San Juan, Puerto Rico.

Results: The motor profile included the speed and inclination of the treadmill. The cardiovascular data had blood pressure and heart rate at the time Ross’s test was terminated. Two hundred and ninety-one participants were further designated as 225 in the non-PN and 66 in the PN group. Both groups average comparable amounts of CD4 counts. An ANOVA was used to determine variations in the PN group with a considerable (P < 0.05) increase in the time of HIV diagnosis and a reduction in gait velocity and treadmill inclination distinguished to counterpart.

Conclusion: Hispanic Latino living with HIV and PN displayed distinctive motor gait deficiencies. Gait parameters, such as gait speed, were further impaired in those suffering from both conditions. We encourage healthcare providers to incorporate the specific cardio-motor items alluded to in this investigation to identify the process influencing gait that further alters the quality of life in those with HIV.

Keywords: Gait complications; HIV ; Peripheral Neuropathy; Ross Test; Hispanic Latinx; Motor Complications

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How to cite this article:
Martín G. Rosario, Leah Jamison, Gabriel Gines. Peripheral Neuropathy Impacts Gait Motor Components in Hispanic-Latinx living with HIV. Internal Journal of Sports Medicine and Rehabilitation, 2021; 4:20. DOI: 10.28933/ijsmr-2021-03-0306


1. Global HIV & AIDS statistics — 2018 fact sheet Accessed [January 2019].
2. Moore, R. D. (2011). Epidemiology of HIV infec-tion in the United States: Implications for linkage to care. Clinical Infectious Diseases, 52(Suppl_2). doi:10.1093/cid/ciq044
3. HIV in the United States by Re-gion. Accessed [January 2019].
4. Comprehensive, up-to-date information On HIV/ AIDS treatment and prevention from the University of California San Francisco. (n.d.). Retrieved February 22, 2021, from
5. Sullivan E, Rosenbloom M, Rohlfing T, Kemper C, Deresinski S, et al. (2011). Pontocerebellar con-tribution to postural instability and psychomotor slowing in HIV infection without dementia. NIH Public Access. 5(1),12-24.
6. Heinze B, Swanepoel D, Hofmeyr L. (2011). Systematic review of vestibular disorders related to human immunodeficiency virus and acquired immunodeficiency syndrome. J Laryngol Otol. 125, 881-891.
7. Chang, L., Tomasi, D., Yakupov, R., Lozar, C., Arnold, S., Caparelli, E., et al. (2004). Adaptation of the attention network in human immunodefi-ciency virus brain injury. Annals of Neurology, 56, 259–272.
8. Paul, R. H., Yiannoutsos, C. T., Miller, E. N., Chang, L., Marra, C. M., Schifitto, G., et al. (2007). Proton MRS and neuropsychological correlates in AIDS dementia complex: Evidence of subcortical specificity. Journal of Neuropsychiatry and Clin-ical Neuroscience, 19(3), 283–292.
9. Sclar G, Kennedy CA, Hill JM, McCormack MK. Cerebellar degeneration associated with HIV in-fection [letter] Neurology. 2000;54:1012–1013.
10. von Giesen HJ, Wittsack HJ, Wenserski F, Koller H, Hefter H, Arendt G. Basal ganglia metabolite abnormalities in minor motor disorders associ-ated with human immunodeficiency virus type 1. Archives of Neurology. 2001;58:1281–1286.
11. Woods, S.P., Moore, D.J., Weber, E. et al. Neuropsychol Rev (2009) 19: 152.
12. Watkins CC, Treisman GJ. Cognitive impairment in patients with AIDS – prevalence and severity. HIV AIDS (Auckl). 2015;7:35-47. Published 2015 Jan 29. doi:10.2147/HIV.S39665
13. Erlandson KM1, Allshouse AA, Jankowski CM, Duong S, Mawhinney S, Kohrt WM, Campbell TB. Comparison of functional status instruments in HIV-infected adults on effective antiretroviral therapy. HIV Clin Trials. 2012 Nov-Dec;13(6):324-34. doi: 10.1310/hct1306-324.
14. Grant, I., Atkinson, J. H., Hesselink, J. R., Ken-nedy, C. J., Richman, D. D., Spector, S. A., et al. (1987). Evidence for early central nervous system involvement in the acquired immunodeficiency syndrome (AIDS) and other human immunodefi-ciency virus (HIV) infections. Studies with neu-ropsychologic testing and magnetic resonance imaging. Annals of Internal Medicine, 107(6), 828–836.
15. Cohen HS, Cox C, Springer G, et al. Prevalence of abnormalities in vestibular function and balance among HIV-seropositive and HIV-seronegative women and men. PLoS One. 2012;7(5):e38419. doi:10.1371/journal.pone.0038419
16. Heinze B, Swanepoel DW, Hofmeyr LM. Sys-tematic review of vestibular disorders related to human immunodeficiency virus and acquired immunodeficiency syndrome. The Journal of Laryngology & Otology. 2011;125(9):881-890. doi:10. 1017/s0022215111001423.
17. Havlik RJ, Brennan M, Karpiak SE. Comorbidities and depression in older adults with HIV. Sex Health. 2011;8(4):551–559.
18. Cross S, Onen N, Gase A, Overton ET, Ances BM. Identifying risk factors for HIV-associated neu-rocognitive disorders using the international HIV dementia scale. J Neuroimmune Pharmacol. 2013; 8(5):1114–1122.
19. Rosario, MG and Gonzalez-Sola M (2018). Au-tonomic nervous system assessment in people with HIV: A cross-sectional study [version 1; ref-erees: awaiting peer review]. F1000 Research., doi: 10.12688/f1000research.14685.1.
20. Bauer, L. O., Ceballos, N. A., Shanley, J. D., & Wolfson, L. I. (2005). Sensorimotor dysfunction IN HIV/AIDS: Effects of antiretroviral treatment AND comorbid psychiatric disorders. AIDS, 19(5), 495-502. doi:10.1097/01.aids.0000162338.66180.0b
21. Saylor, D., Nakigozi, G., Nakasujja, N., Robert-son, K., Gray, R. H., Wawer, M. J., & Sacktor, N. (2017). Peripheral neuropathy in HIV-infected and uninfected patients in Rakai, Uganda. Neurology, 89(5), 485–491.
22. McNamara, L. (2015, October 05). Hiv neuropathy. Retrieved February 22, 2021, from
23. Prior, D. E., Song, N., & Cohen, J. A. (2018). Neuromuscular diseases associated with Human Immunodeficiency Virus infection. Journal of the Neurological Sciences, 387, 27–36. doi: 10.1016 /j.jns.2018.01.016
24. O’Brien KK, Tynan AM, Nixon SA, Glazier RH. Effectiveness of aerobic exercise for adults living with HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol. BMC Infect Dis. 2016;16:182. doi:10.1186/s12879-016-1478.
25. Jaggers JR, Hand GA. Health Benefits of Exer-cise for People Living With HIV: A Review of the Literature. Am J Lifestyle Med. 2014;10(berner3):184‐192. doi:10.1177/1559827614538750.
26. Hand GA, Phillips KD, Dudgeon WD, Lyerly GW, Durstine JL, Burgess SE. Moderate intensity ex-ercise training reverses functional aerobic im-pairment in HIV-infected individuals. AIDS Care. 2008;20(9):1066-1074. doi:10.1080/09540120701796900.
27. O’Brien KK, Tynan AM, Nixon SA, Glazier RH. Effectiveness of Progressive Resistive Exercise (PRE) in the context of HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol. BMC Infect Dis. 2017;17(1):268.
28. Madden, V. J., Parker, R., & Goodin, B. R. (2020). Chronic pain in people with HIV: a common comorbidity and threat to quality of life. Pain management, 10(4), 253–260.
29. Oliveira VH, Wiechmann SL, Narciso AM, Webel AR, & Deminice R. Muscle strength is impaired in men but not in women living with HIV taking an-tiretroviral therapy. Antiviral Therapy. 2018; 23(1), 11-19. doi: 10.3851/IMP3159
30. Schrack JA, Althoff KN, Jacobson LP, et al. Accelerated Longitudinal Gait Speed Decline in HIV-Infected Older Men. J Acquir Immune Defic Syndr. 2015;70(4):370–376. doi:10.1097/QAI.0000000000000731
31. Richert L, Dehai, P, Mercié P, Dauchy FA, Bruyand M, Greib, & Groupe d’Epidémiologie Clinique du SIDA en Aquitaine. High frequency of poor locomotor performance in HIV-infected pa-tients. AIDS. 2011; 25(6), 797-805.
32. Berner K, Morris L, Baumeister J, Louw Q. Ob-jective impairments of gait and balance in adults living with HIV-1 infection: a systematic review and meta-analysis of observational studies. BMC Musculoskeletal Disorders. 2017;18(1).doi:10.1186/s12891-017-1682-2.
33. Rosario, M. (2020)a. Early signs of standing postural instability in asymptomatic people living with HIV. HIV & AIDS Review. International Journal of HIV-Related Problems, 19(3), 193-198.
34. Rosario MG. (2020)b. Gastrocnemius and tibialis anterior neuromuscular modification recruitment during postural standing in people living with HIV. HIV & AIDS Review. International Journal of HIV-Related Problems. ;19(4):260-266. doi:10.5114/hivar.2020.101633.
35. Bauer LO, Wu Z, Wolfson LI. An obese body mass increases the adverse effects of HIV/AIDS on balance and gait. Phys Ther. 2011;91(7):1063–1071. doi:10.2522/ptj.20100292