ASSOCIATION BETWEEN SINGLE NUCLEOTIDE POLYMORPHISM RS4919510 (C>G) IN MIRNA-608 AND BREAST CANCER IN VIETNAMESE POPULATION
Luan Huynh Huu, Thanh Nguyen Thi Ngoc, Hue Nguyen Thi
Faculty of Biology – Biotechnology, University of Science –Vietnam National University, Ho Chi Minh City, Vietnam
Breast cancer (BC) is a complex disease throughout the world and it is one of the most common cancer among women both in developed and developing countries. To enhance the survival of BC patients, genetic factors are used for early diagnosis because they are non-changed factors and present ability of cells to proliferate and metastasize. MiR-608 targets many genes which are vital for development, differentiation, motility, apoptosis and angiogenesis. The SNP rs4919510 (C/G) affects the processing of the pre-miRNA to its mature form and the ability to regulate target genes. This SNP has been demonstrated to relate to breast cancer in Chinese and Iranian population. Our study aimed to investigate the association between the SNP rs4919510 and BC in Vietnamese population. 106 cases and 101 controls were genotyped using optimized tetra-ARMs-PCR method, then statistical analysis was applied to examine the correlation of the SNP. The results show that this SNP is high polymorphism with the frequencies of minor allele C is 24.8% and major allele G is 75.2% in Vietnamese population. Statistic result revealed an obvious increased risk of BC among Vietnamese women when compared of heterozygote model and dominant model (CG vs. GG: OR=1.93, 95% CI: 1.09-3.45, p= 0.02; CC+CG vs. GG: OR=1.83, 95%CI: 1.05-3.17, p=0.03). Our study suggested that the polymorphism of rs4919510 may be associated with BC risk in Vietnamese individuals.
Keywords: rs4919510, miR-608, breast cancer, polymorphism, tetra-ARMs-PCR method.
How to cite this article:
Luan Huynh Huu, Thanh Nguyen Thi Ngoc, Hue Nguyen Thi. ASSOCIATION BETWEEN SINGLE NUCLEOTIDE POLYMORPHISM RS4919510 (C>G) IN MIRNA-608 AND BREAST CANCER IN VIETNAMESE POPULATION.International Research Journal of Obstetrics and Gynecology, 2019, 2:11. DOI: 10.28933/irjog-2019-07-0205
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