Clinical Symptoms and Manifestations of Gestational Diabetes

Clinical Symptoms and Manifestations of Gestational Diabetes

Paulo Henrique Valença Nunes1 *, José Rafael da Silva Araujo2, Alícia Helena Arruda Soares3, Suyane de Deus e Melo2, Camila Marinho da Silva2, Francisco Henrique da Silva4, Matheus Alves Siqueira de Assunção5, Evandro Valentim da Silva6

1Department of Parasitology, Federal University of Pernambuco, Recife, Pernambuco, Brazil; 2Department of Genetics, Federal University of Pernambuco, Recife, Pernambuco, Brazil; 3Graduated in Biomedicine, Federal University of Pernambuco, Recife, Pernambuco, Brazil; 4Department of Biochemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil; 5Department of Histology and Embryology, Federal University of Pernambuco,  Recife, Pernambuco, Brazil; 6Clinical Hospital, Federal University of Pernambuco,  Recife, Pernambuco, Brazil

International Research Journal of Obstetrics and Gynecology

Although there is medical care focused on obstetric and neonatal care, Gestational Diabetes Mellitus (MDG) is still considered one of the main gestational complications, due to numerous metabolic, hematological and anatomical risks for pregnant women, fetuses and newborns. In this chapter, the symptoms and clinical manifestations of pregnant women diagnosed with MDG and their offspring during and after pregnancy will be addressed, presenting the probable sequelae, in addition to the pathogenesis of the main clinical complications.

Keywords: Symptomatology, Clinical manifestations, Pregnancy

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How to cite this article:
Paulo Henrique Valença Nunes, José Rafael da Silva Araujo, Alícia Helena Arruda Soares, Suyane de Deus e Melo, Camila Marinho da Silva, Francisco Henrique da Silva, Matheus Alves Siqueira de Assunção, Evandro Valentim da Silva. Clinical Symptoms and Manifestations of Gestational Diabetes.International Research Journal of Obstetrics and Gynecology, 2020, 3:32. DOI: 10.28933/irjog-2020-06-0805


1. American Diabetes Association (2016) Classifi-cation and diagnosis of diabetes. Diabetes Care.
2. Sociedade Brasileira de Diabetes (SBD). Diretrizes da Sociedade Brasileira de Diabetes 2017-2018. São Paulo: Clannad, 2017. [acesso 2020 may 20] Disponível em:
3. Kitzmiller JL et al (2007) Gestational diabetes af-ter delivery. Short-term management and long-term risks. Diabetes Care. doi:10.2337/dc07-s22
4. Dirar, A. M., & Doupis, J. (2017). Gestational di-abetes from A to Z. World journal of diabetes, 8(12), 489.
5. Metzger, B. E., Buchanan, T. A., Coustan, D. R., De Leiva, A., Dunger, D. B., Hadden, D. R., … & Pettitt, D. J. (2007). Summary and recommenda-tions of the fifth international workshop-conference on gestational diabetes melli-tus. Diabetes care, 30(Supplement 2), S251-S260.
6. Raghav, A., & Ahmad, J. (2014). Glycated serum albumin: a potential disease marker and an in-termediate index of diabetes control. Diabetes & Metabolic Syndrome: Clinical Research & Re-views, 8(4), 245-251.
7. Barcelos, L.F.; Aquino, J.L. (2018). Tratado de Análises Clínicas. 1ª edição. Rio de Janeiro: Atheneu. p. 58-60
8. Nascimento, I. B. D., Sales, W. B., Fleig, R., Silva, G. D. D., & Silva, J. C. (2016). Excesso de peso e dislipidemia e suas intercorrências no período gestacional: uma revisão sistemáti-ca. Revista Brasileira de Saúde Materno In-fantil, 16(2), 93-101.
9. Pascoal, I. F. (2002). Hipertensão e gravidez. Revista Brasileira de Hipertensão, 9(3), 256-261.
10. Menicatti, M., & Fregonesi, C. E. P. T. (2006). Diabetes gestacional: aspectos fisiopatológicos e tratamento. Arquivos de Ciências da Saúde da UNIPAR, 10(2).
11. Petter, C. E., Farret, F., Cícero, T., Souza Scherer, J. D., & Antonello, V. S. (2013). Fatores relacionados a infecções de sítio cirúrgico após procedimentos obstétricos. Scientia Medi-ca, 23(1).
12. Cheung, B. M., & Li, C. (2012). Diabetes and hy-pertension: is there a common metabolic path-way?. Current atherosclerosis reports, 14(2), 160-166.
13. Newton, C. A., & Raskin, P. (2004). Diabetic ke-toacidosis in type 1 and type 2 diabetes melli-tus: clinical and biochemical differ-ences. Archives of internal medicine, 164(17), 1925-1931.
14. O’Neill, K., Alexander, J., Azuma, R., Xiao, R., Snyder, N. W., Mesaros, C. A., … & Pinney, S. E. (2018). Gestational diabetes alters the metab-olomic profile in 2nd trimester amniotic fluid in a sex-specific manner. International journal of mo-lecular sciences, 19(9), 2696.
15. Reece, E. A. (2010). The fetal and maternal con-sequences of gestational diabetes mellitus. The journal of maternal-fetal & neonatal medi-cine, 23(3), 199-203.
16. Kamana, K. C., Shakya, S., & Zhang, H. (2015). Gestational diabetes mellitus and macrosomia: a literature review. Annals of Nutrition and Metabo-lism, 66(Suppl. 2), 14-20.
17. Smith, F. G., & Lumbers, E. R. (1988). Effects of maternal hyperglycemia on fetal renal function in sheep. American Journal of Physiology-Renal Physiology, 255(1), F11-F14.
18. Mazor, M., Ghezzi, F., Maymon, E., Shoham-Vardi, I., Vardi, H., Hershkowitz, R., & Leiber-man, J. R. (1996). Polyhydramnios is an inde-pendent risk factor for perinatal mortality and in-trapartum morbidity in preterm delivery. Europe-an Journal of Obstetrics & Gynecology and Re-productive Biology, 70(1), 41-47.
19. Bolognani, C. V., Souza, S. S. D., & Calderon, I. D. M. P. (2011). Diabetes mellitus gestacional: enfoque nos novos critérios diagnósticos. Comunicação em Ciências da Saúde, 31-42.
20. Voormolen, D. N., de Wit, L., Van Rijn, B. B., DeVries, J. H., Heringa, M. P., Franx, A., … & Lamain-de Ruiter, M. (2018). Neonatal hypogly-cemia following diet-controlled and insulin-treated gestational diabetes mellitus. Diabetes Care, 41(7), 1385-1390.
21. Thompson-Branch, A., & Havranek, T. (2017). Neonatal Hypoglycemia. Pediatrics in review, 38(4), 147-157.
22. Beta, J., Khan, N., Fiolna, M., Khalil, A., Rama-dan, G., & Akolekar, R. (2019). Maternal and ne-onatal complications of fetal macrosomia: co-hort study. Ultrasound in Obstetrics & Gynecol-ogy, 54(3), 319-325.
23. Gokkaya, N., Gungor, A., Bilen, A., Bilen, H., Gviniashvili, D., & Karadeniz, Y. (2016). Primary hyperparathyroidism in pregnancy: a case series and literature review. Gynecological Endocrinol-ogy, 32(10), 783-786.
24. Bashir, B. A., & Othman, S. A. (2019). Neonatal polycythaemia. Sudanese Journal of Paediatrics, 19(2), 81-83.
25. Vlug, R. D., Lopriore, E., Janssen, M., Mid-deldorp, J. M., Rath, M. E., & Smits-Wintjens, V. E. (2015). Thrombocytopenia in neonates with polycythemia: incidence, risk factors and clinical outcome. Expert review of hematology, 8(1), 123-129.
26. Mimouni, F., Miodovnik, M., Siddiqi, T. A., But-ler, J. B., Holroyde, J., & Tsang, R. C. (1986). Neonatal polycythemia in infants of insulin-dependent diabetic mothers. Obstetrics and gy-necology, 68(3), 370-372.
27. Hawdon, J. M. (2012). Neonatal complications following diabetes in pregnancy. Rennie & Rob-erton’s textbook of neonatology, 5th ed. Lon-don: Churchill Livingstone, 387-94.
28. Thevarajah, A., & Simmons, D. (2019). Risk fac-tors and outcomes for neonatal hypoglycaemia and neonatal hyperbilirubinaemia in pregnancies complicated by gestational diabetes mellitus: a single centre retrospective 3‐year review. Diabet-ic Medicine, 36(9), 1109-1117.
29. Azad, M. B., Moyce, B. L., Guillemette, L., Pas-coe, C. D., Wicklow, B., McGavock, J. M., … & Dolinsky, V. W. (2017). Diabetes in pregnancy and lung health in offspring: developmental ori-gins of respiratory disease. Paediatric respirato-ry reviews, 21, 19-26.
30. Mortier, I., Blanc, J., Tosello, B., Gire, C., Bretelle, F., & Carcopino, X. (2017). Is gestation-al diabetes an independent risk factor of neona-tal severe respiratory distress syndrome after 34 weeks of gestation? A prospective study. Ar-chives of gynecology and obstetrics, 296(6), 1071-1077.
31. Bricelj, K., Tul, N., Lucovnik, M., Kronhauser-Cerar, L., Steblovnik, L., Verdenik, I., & Blickstein, I. (2017). Neonatal respiratory morbid-ity in late-preterm births in pregnancies with and without gestational diabetes mellitus. The Journal of Maternal-Fetal & Neonatal Medicine, 30(4), 377-379.
32. Zhao, P., Liu, E., Qiao, Y., Katzmarzyk, P. T., Chaput, J. P., Fogelholm, M., … & Maher, C. (2016). Maternal gestational diabetes and child-hood obesity at age 9–11: results of a multina-tional study. Diabetologia, 59(11), 2339-2348.
33. Ornoy, A. (2011). Prenatal origin of obesity and their complications: Gestational diabetes, mater-nal overweight and the paradoxical effects of fe-tal growth restriction and macro-somia. Reproductive toxicology, 32(2), 205-212.
34. Sousa, R. A. D., Torres, Y. S., Figueiredo, C. P., Passos, G. F., & Clarke, J. R. (2018). Conse-quences of gestational diabetes to the brain and behavior of the offspring. Anais da Academia Brasileira de Ciências, 90(2), 2279-2291.
35. Ornoy, A., Wolf, A., Ratzon, N., Greenbaum, C., & Dulitzky, M. (1999). Neurodevelopmental out-come at early school age of children born to mothers with gestational diabetes. Archives of Disease in Childhood-Fetal and Neonatal Edi-tion, 81(1), F10-F14.
36. Ornoy, A., Ratzon, N., Greenbaum, C., Peretz, E., Soriano, D., & Dulitzky, M. (1998). Neurobe-haviour of school age children born to diabetic mothers. Archives of Disease in Childhood-Fetal and Neonatal Edition, 79(2), F94-F99.