Gestational Diabetes Mellitus: highlights about biochemical agents that subscribe its physiopathological mechanism during gestational trimesters


Gestational Diabetes Mellitus: highlights about biochemical agents that subscribe its physiopathological mechanism during gestational trimesters


João Ricardhis Saturnino de Oliveira1 *, Aedson Pereira da Silva2, Bianka Santana dos Santos1,3, Priscila Pereira Passos4, Anselmo Queiroz Alves5, Francisco Henrique da Silva6 , Fálba Bernadete Ramos dos Anjos6, Vera Cristina Oliveira de Carvalho1, Matheus Alves Siqueira de Assunção6, Vera Lúcia de Menezes Lima1

1Department of Biochemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil; 2International Faculty of Paraíba, João Pessoa, Paraíba, Brazil; 3Life Sciences Center, Campus Agreste, Federal University of Pernambuco, Caruaru, Pernambuco, Brazil; 4University Center Maurício de Nassau, Recife, Pernambuco, Brazil; 5Hematology and Hemotherapy Hospital of Pernambuco, Recife, Pernambuco, Brazil; 6Department of Histology and Embryology, Federal University of Pernambuco, Recife, Pernambuco, Brazil


International Research Journal of Obstetrics and Gynecology

Gestational Diabetes Mellitus (GDM) is a common complication in which hyperglycemia goes by physiological state, beneficial to the embryo, to metabolic condition that causes damage to both mother and child. Placental hormones, insulin resistance, visceral fat tissue, dyslipidemia, and other biochemical agentes, subscribe the physiopathological mechanisms that lead to GDM. Nowadays, there are mRNAs, proteins, and even vitamins being associated with GDM risk and its pathophysiology. These new pathways usher a new horizon to discover and describe other important parts of metabolism that play a key role to GDM. With a larger picture of pregnant women metabolism prior and after GDM, better predictors and efficient treatment can be managed.


Keywords: Gestational Diabetes Mellitus, biochemical agents , physiopathological mechanism , gestational trimesters

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How to cite this article:
João Ricardhis Saturnino de Oliveira, Aedson Pereira da Silva, Bianka Santana dos Santos, Priscila Pereira Passos, Anselmo Queiroz Alves, Francisco Henrique da Silva, Fálba Bernadete Ramos dos Anjos, Vera Cristina Oliveira de Carvalho, Matheus Alves Siqueira de Assunção, Vera Lúcia de Menezes Lima.Gestational Diabetes Mellitus: highlights about biochemical agents that subscribe its physiopathological mechanism during gestational trimesters .International Research Journal of Obstetrics and Gynecology, 2020, 3:34. DOI: 10.28933/irjog-2020-06-2005


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