HPV-Negative Vulvar Squamous Cell Carcinoma in a 21-year-old Patient
Dânia Ferreira1*, Paulina Corgo2, Vanda Patrício3, Amelia de Almeida4
1Hospital de Braga. 2Centro Hospitalar Medio Ave, Famalicão. 3Instituto Português de Oncologia do Porto. 4Centro Hospitalar Medio Ave, Famalicão.
Vulvar Squamous Cell Carcinoma usually occurs among women in their 60s or 70s. There are a limited number of reports of vulvar cancer cases younger than 30 years. These patients have usually risk factors such as human papillomavirus (HPV) infection.
In this report, the authors present a rare case of invasive vulvar squamous cell carcinoma in a 21-year-old patient without HPV infection. Surgical treatment was performed, followed by adjuvant radiation therapy.
Keywords: HPV; Vulvar Squamous Cell Carcinoma
How to cite this article:
Dânia Ferreira, Paulina Corgo, Vanda Patrício, Amelia de Almeida. HPV-Negative Vulvar Squamous Cell Carcinoma in a 21-year-old Patient. International Research Journal of Obstetrics and Gynecology, 2021; 4:36. DOI: 10.28933/irjog-2020-11-2505
1. Berek J, Karam A. Vulvar cancer: Epidemiology, diagnosis, histopathology, and treatment of rare histologies. UpToDate 2018.
2. Crum CP. Carcinoma of the vulva: epidemiology and pathogenesis. Obstet Gynecol. 1992; 79:448–454.
3. Monk BJ, Burger RA, Lin F, et al. Prognostic significance of human papillomavirus DNA in vulvar carcinoma. Obstet Gynecol. 1995; 85:709-715.
4. Insinga RP, Liaw KL, Johnson LG, Madeleine MM. A systematic review of the prevalence and attribution of human papillomavirus types among cervical, vaginal, and vulvar precancers and cancers in the United States. Cancer Epidemiol Biomarkers Prev 2008; 17:1611-1622.
5. Dong F, Kojiro S, Borger DR, Growdon WB, Oliva E. Squamous cell carcinoma of the vulva: a subclassification of 97 cases by clinico- pathologic, immunohistochemical, and molecu- lar features (p16, p53, and EGFR). Am. J. Surg. Pathol. 2015; 39: 1045–1053.
6. Scurry JP, Vanin K. Vulvar squamous cell carcinoma and lichen sclerosus. Australas J Dermatol. 1997, 38 (Suppl 1): S20-S25.
7. de Koning MN, Quint WG, Pirog EC. Prevalence of mucosal and cutaneous human papilloma viruses in different histologic subtypes of vulvar carcinoma. Mod Pathol 2008; 21:334-344.
8. Kaur P, Bhatia R, Dev Singh A, Gupta R. Squamous Cell Carcinoma Vulva in a Young Woman – case report. Annals of Applied Bio-Sciences 2016; 3(4): 60-63.
9. Mohan Rao TS, Bellam SS, Gurupuprasad P. Vulvar invasive squamous cell carcinoma in a young patient with Human Immunodeficiency Virus-seropositivity. Indian Journal of Sexually Transmitted Diseases and AIDS 2015; 36(2): 204-206.
10. Echeverri C, Stoler MH, Valente PT. Vulvar Keratinizing Squamous Cell Carcinoma in a 26-Year-Old Woman. Archives of Pathology & Laboratory Medicine 2001; 125(2):267-70.
11. Kahramanoglu I, Turan H, et al. A Very Rare Case: HPV-Negative Vulvar Cancer in an Adolescent. Case Reports in Obstetrics and Gynecology, 2018; 2018: 1-3.
12. Royal College of Obstetricians and Gynae- cologists. Guidelines for the Diagnosis and Management of Vulvar Carcinoma. London: RCOG; 2014.
13. Eva LJ. Screening and follow up of vulval skin disorders. Best Pract Res Clin Obstet Gynae- col. 2012; 26(2):175–188.
14. Chi CC, Kirtschig G, Baldo M, Lewis F, Wang SH, Wojnarowska F. Systematic review and meta-analysis of randomized controlled trials on topical interventions for genital lichen sclero- sus. J Am Acad Dermatol. 2012; 67(2): 305–312.
15. Bradford J, Fischer G. Long-term management of vulval lichen sclerosus in adult women. Aust N Z J Obstet Gynaecol. 2010; 50(2): 148–152.
16. Madeleine MM, Daling JR, Carter JJ, et al. Cofactors with human papillomavirus in a population-based study of vulvar cancer. J Natl Cancer Inst. 1997; 89(20): 1516–1523.
17. Scurry J. Does lichen sclerosus play a central role in the pathogenesis of human papillo- mavirus negative vulvar squamous cell carci- noma? The itch-scratch–lichen sclerosus hypo- thesis. Int J Gynecol Cancer. 1999; 9(2): 89–97.
18. Cooper SM, Gao XH, Powell JJ, Wojnarowska F. Does treatment of vulvar lichen sclerosus influence its prognosis? Arch Dermatol. 2004; 140(6): 702-706.