Effects of Myrica esculenta Bark Extracts on Melanin Biosynthesis

Effects of Myrica esculenta Bark Extracts on Melanin Biosynthesis

Kenji Ohguchi1*, Rie Ozaki1

1 Department of Food and Nutrition, Sugiyama Jogakuen University, Aichi, Japan


In this study, we investigated the effect of crude extracts, derived from stem bark of Myrica esculenta on melanin production in mouse B16 melanoma cells. In response to a-melanocyte stimulating hormone (a-MSH), B16 melanoma cells underwent differentiation characterized by increased melanin biosynthesis. Treatment of Myrica esculenta bark extracts significantly blocked a-MSH-induced melanogenesis in a dose-dependent manner. a-MSH stimulated the activity of tyrosinase, a key melanogenic enzyme in melanin biosynthesis, which was significantly reduced by Myrica esculenta bark extracts. In addition, treatment of B16 melanoma cells with Myrica esculenta bark extracts decreased the protein expression level of tyrosinase. These results demonstrated that the inhibitory effects of Myrica esculenta bark extracts on melanogenesis may be due to the suppression of tyrosinase protein levels.

Keywords: Myrica esculenta bark extracts, Myricaceae, Melanin, Melanogenesis, Tyrosinase

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